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About

I am a Child and Adolescent Psychiatrist based at Cambridge University pursuing research into the connections between human development and psychopathology. My studies are centred on adolescents in the community as well as current patients. Our research programme uses experimental and neuroimaging approaches embedded in longitudinal designs to measure the effects of genes and the social environment, on cognition and brain structures. We use these methods in epidemiological cohort studies of adolescent development and randomised controlled trials of treatment for depression and conduct disorders.

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Skills

Experience

Professor

University of Cambridge

Dec-2005 to Present

Publication

  • dott image February, 2020

Multiple Holdouts With Stability: Improving the Generalizability of Machine Learning Analyses of Brain–Behavior Relationships

Background In 2009, the National Institute of Mental Health launched the Research Domain Criteria, an attempt to move beyond diagnostic categories and ground psychiatry within neurobiologic...

  • dott image February, 2020

White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood

Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that co...

  • dott image February, 2020

Conservative and disruptive modes of adolescent change in human brain functional connectivity

Journal : Proceedings of the National Academy of Sciences 1091-6490

Adolescent changes in human brain function are not entirelyunderstood. Here, we used multiecho functional MRI (fMRI) tomeasure developmental change in functional connectivity (FC) ofresting-...

  • dott image October, 2019

Identifying key targets for interventions to improve psychological wellbeing: replicable results from four UK cohorts

Background An increasing importance is being placed on mental health and wellbeing at individual and population levels. While there are several interventions that have been proposed to impr...

  • dott image August, 2019

Brain-behaviour modes of covariation in healthy and clinically depressed young people

Understanding how variations in dimensions of psychometrics, IQ and demographics relate to changes in brain connectivity during the critical developmental period of adolescence and early adu...

  • dott image Graham Murray
  • dott image August, 2019

SA97COMPUTATIONAL PSYCHIATRY MEETS GENETICS: REINFORCEMENT LEARNING IN EARLY PSYCHOSIS AND IN RELATION TO CLINICAL AND MOLECULAR GENETIC RISK FOR SCHI...

Computational psychiatry offers opportunities for increased mechanistic understanding of mental disorder and to aid in the integration between psychiatry and neuroscience. By developing an...

  • dott image June, 2019

Compulsivity and impulsivity traits linked to attenuated developmental frontostriatal myelination trajectories

The transition from adolescence to adulthood is a period when ongoing brain development coincides with a substantially increased risk of psychiatric disorders. The developmental brain change...

  • dott image June, 2019

Compulsivity and impulsivity traits linked to attenuated developmental frontstriatal myelination trajectories

A transition from adolescence into adulthood corresponds to a period where rapid brain development coincides with an enhanced incidence of psychiatric disorder. The precise developmental bra...

  • dott image April, 2019

Conservative and disruptive modes of adolescent change in brain functional connectivity

Adolescent changes in human brain function are not entirely understood. Here we used multi-echo functional magnetic resonance imaging (fMRI) to measure developmental change in functional con...

  • dott image December, 2018

Change, stability, and instability in the Pavlovian guidance of behaviour from adolescence to young adulthood

Pavlovian influences are important in guiding decision-making across health and psychopathology. There is an increasing interest in using concise computational tasks to parametrise such infl...