Peter B Jones
Professor Emeritus & Clinical Director of Research
at University of Cambridge
📚 Professor of Psychiatry & Deputy Head, University of Cambridge
|
Cambridge, Cambridge, United Kingdom
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👤 About
Peter qualified in medicine at Westminster Medical School. Having first worked as a physician at The Whittington Hospital and KCH, he trained in psychiatry at the Maudsley Hospital and epidemiology at the London School of Hygiene. He has been Professor of Psychiatry at Cambridge since 2000, Head of Department of Psychiatry from 2000-2014, and Deputy Head of the Clinical School since 2014. He has been a NIHR CLARHC Director since 2008 and is a NIHR Senior Investigator.
Peter’s research interests are in the epidemiology of mental illness, particularly early life determinants, and in evaluation of effective interventions at the individual and system level. Clinically he co-led the award winning CAMEO.nhs.uk early intervention service until taking on his NIHR responsibilities in the Collaboration for Leadership in Applied Health Research & Care East of England.
Peter studied medicine at KCL and Westminster Medical School. He practised hospital medicine for three years before tasting psychiatry at the Maudsley Hospital and Institute of Psychiatry where he remained for nine years becoming an honorary consultant and senior lecturer; three of these were spent as an MRC Training Fellow and reading Epidemiology at the London School of Hygiene and Tropical Medicine. He was seconded half-time to the Department of Health 1993-1996 where he led the Policy Research Programme Mental Health Research Initiative and convened the multi-party group that led to the reduction in paracetamol pack size as part of the national suicide prevention policy.
After five years at the University of Nottingham, four as Professor of Psychiatry and Community Mental Health, Peter moved to Cambridge in 2000 as Head of Department of Psychiatry and honorary consultant psychiatrist with the Cambridgeshire & Peterborough NHS Foundation Trust.; he was co-founder of the award-winning Cameo early intervention team for young people who experience a first episode of psychosis. In 2014 he stepped-down as Head of Department to become Deputy Head of the School of Clinical Medicine.
Peter was elected a Fellow of Wolfson College in 2003. He is a Director of Cambridge University Health Partners, and Director of the National Institute of Health Research (NIHR) Collaboration for Leadership in Applied Health Research & Care for the East of England (CLAHRC EoE). He is a trustee of MQ: transforming mental health, a research charity endowed by the Wellcome Trust, and is an NIHR Senior Investigator Emeritus. Peter has been President of IEPA Early Intervention in Mental Health 2016-2018.
Skills & Expertise
Epidemiology
Research
Neuroimaging
Neuroscience
Research Interests
Public Health
Psychology
Epidemiology
Community mental health
Clinical Medicine
Psychiatry
Clinical Trials
Mental Health Epidemiology
Early Life Determinants of Mental Illness
Early Intervention in Psychosis
Mental Health Policy
Suicide Prevention
Applied Health Research
Intervention Evaluation
Health Services Research
NIHR Leadership
Academic Psychiatry
Psychosis Management
Public Health Interventions
Mental Health Charity
Early Intervention Services
Psychiatry Education
Health Research Collaboration
Connect With Me
💼 Experience
Professor Emeritus & Clinical Director of Research
University of Cambridge
·
October 2000 -
Present
- Director, NIHR ARC East of England (previously CLAHRC) 2008-2022 Deputy Head, School of Clinical Medicine, 2014-2021 Head of Department of Psychiatry, 2000-2014 NED, Cambridgeshire & Peterborough Mental Health Partnership Trust (predecessor organisation to CPFT), 2001-05 and 2017-21
Governing Body Fellow
Wolfson College, Cambridge
·
March 2003 -
December 2024
- Council member (trustee), 2020-26
Honorary consultant psychiatrist
Cambridgeshire and Peterborough NHS Foundation Trust (CPFT)
·
October 2000 -
December 2024
Professor of psychiatry & community mental health
University of Nottingham
·
September 1995 -
September 2000
Senior Lecturer & honorary consultant psychiatrist
Institute of Psychiatry, Psychology & Neuroscience (IoPPN)
·
September 1991 -
September 1995
Registrar & Senior Registrar
Bethlem Royal Hospital
·
October 1987 -
September 1991
- Maudsley psychiatry training rotation
Medical Registrar
King’s College Hospital NHS Foundation Trust
·
February 1987 -
September 1987
Medical SHO
Whittington Hospital
·
February 1986 -
January 1987
- Medical SHO rotation
Casualty Officer
Chelsea and Westminster Hospital
·
February 1985 -
January 1986
House Surgeon
Royal Surrey County Hospital
·
August 1984 -
January 1985
🎓 Education
Institute of Psychiatry, Psychology & Neuroscience (IoPPN)
Ph.D. in
Psychiatry
· 1995
London School of Hygiene & Tropical Medicine (LSHTM)
M.Sc. in
Epidemiology
· 1992
Westminster Hospital Medical School (WHMS)
MBBS in
Medicine
· 1984
King's College London
B.Sc. in
Neurobiology and Anatomy
· 1981
🚀 Projects
Access to Expertise for Cambridge Adaptive Testing - Mental health screening platforms – medical device considerations
Agency Name: Wellcome Trust (London, GB) ||
April 2023 - April 2023
Funded: Yes ||
Amount: GBP 6,144
Administered by Cambridge Academy of Therapeutic Sciences
Cogs AI - Social - Emotional Screener for Neurodiverse Children
Agency Name: Innovate UK (Swindon, GB) ||
January 2023 - December 2024
Funded: Yes ||
Amount: GBP 414,918
Academic partner (and applicant) with Jan Stochl applying adaptive testing technology to a screening app. Cogs AI is the academic partner.
Early Psychosis Multi-arm Multi-stage Platform Trial (PUMA)
Agency Name: Wellcome (London, GB) ||
Jan 2024 - Jan 2024
Funded: Yes ||
Amount: GBP 1,390,427
Establishing an adaptive trials platform for early psychosis. CI Belinda Lennox, University of Oxford.
Market research for Cambridge Adaptive Testing Ltd.
Agency Name: University of Cambridge ||
May 2024 - Dec 2024
Funded: Yes ||
Amount: GBP 20,000
🎤 Conferences & Seminars (1)
Predicting Population-level Need for Early Treatment Programmes in First Episode Psychosis: The Advanced Psychiatric MAPping Translated into Innovations for Care [PsyMaptic-A] Study
Wiley · Hoboken,
New Jersey, Country ·
December 2018
No descriptions
Professional Memberships (2)
University of Cambridge
Member: Emeritus Professor of Psychiatry || Join dt:
2021 - Present
Country: United Kingdom
Mental Health Research UK
Member: Trustee || Join dt:
2019 - Present
Country: United Kingdom
💡 Patents (3)
Model directed sampling system
Patent No. US20160259844A1 · Filed
March 2016 · Issued on September 2016
Inventors: Kirill Trapeznikov, Gary Richard Condon, Eric Kimball Jones, Peter Brunson Jones, Nicholas John Pioch || Category:
Medical & Health Science
description
Matched mailer form
Patent No. US5174491A · Filed
December 1992 · Issued on December 1992
Inventors: Donald Taylor, Phillip Jones, Julie Ann Zarth || Category:
Medical & Health Science
description
Systems and Methods for Managing Documents and Other Electronic Content
Patent No. US20140298207A1 · Filed
March 2014 · Issued on October 2014
Inventors: Gadi Ittah, David P. Maher, Daniel Vickery, Peter Jones, Sung Chun, Tauseef Bashir || Category:
Medical & Health Science
description
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📚 Publications (221)
Journal: Psychological Medicine
• September 2021
Background
First episode psychosis (FEP) patients who use cannabis experience more frequent psychotic and euphoric intoxication experiences compared to controls. It is not clear whether this is conse...
Journal: BMC Medical Research Methodology
• September 2020
Background
There is consensus that health services commissioning and clinical practice should be driven by scientific evidence. However, workload pressures, accessibility of peer reviewed publication...
Journal: Psychological Medicine
• September 2019
Psychiatry's most recent foray into the area of risk and prevention has been spear-headed by work on at-risk mental states for psychotic disorders. Twenty-five years' research and clinical application...
Journal: Psychological Medicine
• September 2019
Background
Peripheral low-grade inflammation in depression is increasingly seen as a therapeutic target. We aimed to establish the prevalence of low-grade inflammation in depression, using different...
Journal: Psychological Medicine
• September 2019
Background
Neuropsychological investigations can help untangle the aetiological and phenomenological heterogeneity of schizophrenia but have scarcely been employed in the context of treatment-resista...
Journal: BMJ Open
• September 2018
Introduction Observational studies indicate a potentially causal role for interleukin 6 (IL-6), a proinflammatory cytokine, in pathogenesis of depression, but interventional studies based on patients...
Journal: JAMA Psychiatry
• September 2018
Schizophrenia has long been reported to be more common in urban areas,1,2 although recent research suggests this association may not occur in low- and middle-income countries.3 Explanations of this ur...
Journal: Schizophrenia Research
• September 2018
Objective
To describe the characteristics of individuals with early sustained recovery following first episode psychosis.
Methods
Individuals with a first episode psychosis were followed-up for ten...
Journal: Assessment
• September 2018
The factorial structure of the Parental Bonding Instrument (PBI) has been frequently studied in diverse samples but no study has examined its psychometric properties from large, population-based sampl...
Journal: Social Science Research Network Electronic Journal
• September 2018
Background: Recent evidence suggests that multiple symptoms or diagnoses, partucularly when co-ocuring with non-suicidal self-harm, predict suicide risk more strongly than single diagnosis.
Metho...
Journal: Journal of Public Mental Health
• September 2017
Purpose
The purpose of this paper is to expand upon policy implications of a recent study assessing adolescent mental health service contact and subsequent depression.
Design/methodology/approach...
Journal: European Psychiatry
• September 2017
Background:
Higher lifetime antipsychotic exposure has been associated with poorer cognition in schizophrenia. The cognitive effects of adjunctive psychiatric medications and lifetime trends of antip...
Journal: Veterinary Record
• September 2017
The Royal College of Veterinary Surgeons now lists ‘How to evaluate evidence’ as a day one competence for newly qualified vets. In this article, representatives from each of the veterinary schools in...
Journal: European Psychiatry
• September 2017
Background:
Higher lifetime antipsychotic exposure has been associated with poorer cognition in schizophrenia. The cognitive effects of adjunctive psychiatric medications and lifetime trends of antip...
Journal: BMJ Open
• September 2016
Introduction Levels of stress in UK university students are high, with an increase in the proportion of students seeking help in recent years. Academic pressure is reported as a major trigger. Mindful...
Journal: Patient Preference and Adherence
• September 2016
Objectives
The objectives of this study were to determine the perceptions of European physicians, nurses, and pharmacists about the extent of nonadherence by patients in their country relative to the...
Journal: European Neuropsychopharmacology
• September 2016
Metabolic complications are commonly found in people treated with clozapine. Reviews on the management of this problem have generally drawn conclusions by grouping different types of studies involving...
Journal: International Journal of Methods in Psychiatric Research
• September 2016
Statistical theory indicates that hierarchical clustering by interviewers or raters needs to be considered to avoid incorrect inferences when performing any analyses including regression, factor analy...
Journal: The Lancet Digital Health
• October 2019
Background
Outcomes for people with first-episode psychosis are highly heterogeneous. Few reliable validated methods are available to predict the outcome for individual patients in the first clinical...
Journal: Psychological Medicine
• October 2019
Background
Although relapse in psychosis is common, a small proportion of patients will not relapse in the long term. We examined the proportion and predictors of patients who never relapsed in the 1...
Journal: Psychological Medicine
• October 2019
Background
An increasing importance is being placed on mental health and wellbeing at individual and population levels. While there are several interventions that have been proposed to improve wellbe...
Journal: Metabolites
• October 2018
It has become increasingly important to qualitatively and quantitatively assess the volatile metabolites in a range of bodily fluids for use in monitoring health. There has been relatively little work...
Journal: Developmental Cognitive Neuroscience
• October 2018
Assessing and analysing individual differences in change over time is of central scientific importance to developmental neuroscience. However, the literature is based largely on cross-sectional compar...
Journal: Molecular Psychiatry
• October 2018
Inflammatory cytokines are commonly elevated in acute depression and are associated with resistance to monoaminergic treatment. To examine the potential role of cytokines in the pathogenesis and treat...
Journal: Psychological Medicine
• October 2017
Background
Differences between verbal and non-verbal cognitive development from childhood to adulthood may differentiate between those with and without psychotic symptoms and affective symptoms in la...
Journal: Frontiers in Psychology
• October 2017
Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored....
Journal: Annals of Emergency Medicine
• October 2017
Study objective
The influence of the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) on the conduct of future sepsis research is unknown. We seek to examine the poten...
Journal: Psychological Medicine
• October 2017
Background
Adolescence is a key time period for the emergence of psychosocial and mental health difficulties. To promote adolescent adaptive (‘resilient’) psychosocial functioning (PSF), appropriate...
Journal: Canadian Journal of Cardiology
• October 2017
Background
To evaluate the natural history of aortic root graft geometry, aortic valve competency and patient prognosis following a valve sparing aortic root reconstruction.
Methods and Results
Bet...
Journal: Schizophrenia Research
• October 2017
The neurodevelopmental hypothesis of schizophrenia proposes that impaired brain development is a cause of the illness. Early motor developmental milestones, such as learning to walk, are predictors of...
Journal: American Journal of Psychiatry
• October 2016
Objective:
Few studies have characterized the epidemiology of first-episode psychoses in rural or urban settings since the introduction of early intervention psychosis services. To address this, the...
Journal: Australian & New Zealand Journal of Psychiatry
• October 2016
Objective:
To compare baseline demographics and 10-year outcomes of a first-episode psychosis patient incidence cohort in order to establish whether current youth-focussed age-based criteria for earl...
Journal: Endocrine Abstracts
• October 2016
Turner’s syndrome (TS) results from a genetic abnormality in phenotypical female individuals where the second X chromosome is either absent or present in a mosaic form. The most obvious consequences a...
Journal: Philosophical Transactions of the Royal Society B: Biological Sciences
• October 2016
Human functional magnetic resonance imaging (fMRI) brain networks have a complex topology comprising integrative components, e.g. long-distance inter-modular edges, that are theoretically associated w...
Journal: Astronomy & Astrophysics
• October 2016
Context. Stars form in dense, dusty structures, which are embedded in larger clumps of molecular clouds often showing a clear filamentary structure on large scales (≳1 pc). The origin (e.g., turbulenc...
Journal: Acta Psychiatrica Scandinavica
• October 2016
Objective
The incidence and outcome of first-episode substance-induced psychotic disorder (SIPD) are unclear. The study aimed to compare the 1-year outcomes of those given a SIPD diagnosis by clinici...
Journal: Neurobiology of Stress
• October 2016
Background
Animal studies suggest a role of inflammation in the pathophysiology of anxiety, but human studies of inflammatory markers and anxiety disorders are scarce. We report a study of serum C-re...
Journal: medRxiv
• November 2019
Background Diagnostic categories within the psychosis spectrum are widely used in clinical practice, however psychosis may occur on a continuum. Therefore, we explored whether the continuous distribut...
Journal: bioRxiv
• November 2019
Background: Some recent studies have challenged the direction of causality for the association between cannabis use and psychotic disorder, suggesting that cannabis use initiation is explained by comm...
Journal: HPB
• November 2018
Background
Intravenous (IV) fluid resuscitation remains the cornerstone for early management of acute pancreatitis (AP), but many questions remain unanswered, including how to determine whether patie...
Journal: The Lancet Psychiatry
• November 2018
Background
The antibiotic minocycline has neuroprotective and anti-inflammatory properties that could prevent or reverse progressive neuropathic changes implicated in recent-onset schizophrenia. In t...
Journal: Monthly Notices of the Royal Astronomical Society
• November 2018
It is shown that the ion–proton magnetosphere is unstable in a limited area of the P–P˙ plane
against transitions to a self-sustaining inverse Compton scattering mode in which the particles
accelera...
Journal: Monthly Notices of the Royal Astronomical Society
• November 2018
Salient features of the remarkable band structure seen in the high-frequency interpulse of the Crab pulsar are summarized. It is argued that its source must lie in a current sheet, probably coincident...
Journal: Early Intervention in Psychiatry
• November 2017
Aim
Early intervention in psychosis (EIP) is a well-established approach with the intention of early detection and treatment of psychotic disorders. Its clinical and economic benefits are well docume...
Journal: JAMA Psychiatry
• November 2017
Importance Social determinants are important risk factors for the development of first-episode psychosis (FEP); their effects in rural areas are largely unknown.
Objective To investigate neighbor...
Journal: Brain, Behavior, and Immunity
• November 2017
Inflammatory cytokines are commonly elevated in acute depression and are associated with resistance to monoaminergic treatment. To examine the potential role of cytokines in the pathogenesis and treat...
Journal: Schizophrenia Research
• November 2017
A need for a brief, easy to complete self-report questionnaire to detect people at ultra-high risk for psychosis (UHR) in busy clinical settings has been recognised. Our aim was to explore whether the...
Journal: Schizophrenia Bulletin
• November 2017
Objective
Several ethnic minority groups experience elevated rates of first-episode psychosis (FEP), but most studies have been conducted in urban settings. We investigated whether incidence varied b...
Journal: Journal of the American Academy of Dermatology
• November 2016
Background
Pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment.
Objective
We sought to estimate the effectiveness of topical therapies in the treatment of...
Journal: The Lancet Psychiatry
• November 2016
Social networking sites are a part of everyday life for over a billion people worldwide.1 They show no sign of declining popularity, with social media use increasing at three times the rate of other i...
Journal: The Lancet
• November 2016
Background
Levels of stress in university students in the UK are high, with an increase in the proportion of students seeking help in recent years. Students report academic pressure as a major trigge...
Journal: The Sixties
• November 2016
The periodization of historical periods is a familiar yet problematic tendency. Epochs don’t start or end cleanly. Moreover, it can entail some sort of unifying, idealist spirit of the age. As Fredric...
Journal: Schizophrenia Bulletin
• November 2015
Objective:
The use of cannabis during the early stage of psychosis has been linked with increased psychotic symptoms. This study aimed to examine the use of cannabis in the 12 months following a firs...
Sexually divergent development of depression-related brain networks during healthy human adolescence
Journal: Science Advances
• May 2022
Sexual differences in human brain development could be relevant to sex differences in the incidence of depression during adolescence. We tested for sex differences in parameters of normative brain net...
Journal: Human Brain Mapping
• May 2020
Socio-economic disadvantage increases exposure to life stressors. Animal research suggests early life stressors impact later neurodevelopment, including myelin developmental growth. To determine how e...
Journal: Schizophrenia Bulletin
• May 2020
Background
Insulin Resistance (IR) predisposes to cardiometabolic disorders, which are common in schizophrenia and are associated with excess morbidity and mortality. The mechanisms of association re...
Journal: Schizophrenia Bulletin
• May 2020
Psychotic patients with a lifetime history of cannabis use generally show better cognitive functioning than other psychotic patients. Some authors suggest that cannabis-using patients may have been le...
Journal: Systematic Reviews
• May 2019
Background
Many people who have common mental disorders, such as depression and anxiety, also have some psychotic experiences. These experiences are associated with higher clinical complexity, poor t...
Journal: Biological Psychiatry
• May 2019
Association of inflammation with symptoms that are commonly shared between psychiatric disorders may help to explain the apparent trans-diagnostic effect of inflammation, which is associated with depr...
Journal: Biological Psychiatry
• May 2019
Although the association between low-grade inflammation and depression is well established, few studies have investigated this association at the symptom level. We studied the longitudinal association...
Journal: The Lancet Public Health
• May 2019
Background
The last comprehensive systematic review of the incidence of psychotic disorders was published in 2004. New epidemiological data from different settings now permit a broader understanding...
Journal: Translational Vision Science and Technology
• May 2019
Purpose: To describe and evaluate a free, online tool for automatically segmenting optical coherence tomography (OCT) images from different devices and computing summary measures such as retinal thick...
Journal: The Lancet Psychiatry
• May 2019
Background
Cannabis use is associated with increased risk of later psychotic disorder but whether it affects incidence of the disorder remains unclear. We aimed to identify patterns of cannabis use w...
Journal: Psychoneuroendocrinology
• May 2018
Low-grade inflammation is a risk factor for depression, psychosis and other major psychiatric disorders. It is associated with poor response to antidepressant and antipsychotics, and could potentially...
Journal: The Lancet Psychiatry
• May 2018
Background
The long-term consequences of discontinuing antipsychotic medication after successful treatment of first-episode psychosis are not well studied. We assess the relation between early mainte...
Journal: NeuroImage
• May 2018
Complex network topology is characteristic of many biological systems, including anatomical and functional brain networks (connectomes). Here, we first constructed a structural covariance network from...
Passive hypothermia (≥35 - <36°C) during transport of newborns with hypoxic-ischaemic encephalopathy
Journal:
• May 2017
Background
Hypothermia initiated in the first six hours of life in term infants with hypoxic ischemic encephalopathy reduces the risk of death and severe neurological sequelae. Our study's principal...
Journal: Biological Psychiatry
• May 2017
Adolescence is a period of human brain growth and high incidence of mental health disorders. The Neuroscience in Psychiatry Network seeks to understand biological underpinnings of the adolescent risk...
Journal:
• May 2016
Background
Early life stress (ELS) consists of child family adversities (CFA: negative experiences that happened within the family environment) and/or peer bullying. ELS plays an important role in th...
Journal: Schizophrenia Bulletin
• May 2016
Cognitive impairment is a core feature of schizophrenia but there is limited understanding of the genetic relationship between cognition in the general population and schizophrenia. We examine how com...
Journal: European Archives of Psychiatry and Clinical Neuroscience
• March 2020
The objective of this study is to determine whether cannabis influences BDNF levels in patients with psychosis (FEP) and healthy volunteers (HV) to help understand the role of BDNF in psychosis. We as...
Journal: BMJ Open
• March 2020
Objectives To inform suicide prevention policies and responses to youths at risk by investigating whether suicide risk is predicted by a summary measure of common mental distress (CMD (the p factor))...
Journal:
• March 2020
Background
To estimate the potential gain in life expectancy from addressing modifiable risk factors for all-cause mortality (excluding suicide and deaths from accidents or violence) across specific...
Journal: Translational Psychiatry
• March 2020
Low self-esteem is a risk factor for a range of psychiatric disorders. From a cognitive perspective a negative self-image can be maintained through aberrant learning about self-worth derived from soci...
Journal: bioRxiv
• March 2019
Objective The evidence is mixed on whether cannabis use is associated with a particular symptomatology in first episode psychosis (FEP) patients.
The authors set out to investigate a) patterns of a...
Journal: The Lancet
• March 2019
Background
High blood pressure is common in acute stroke and is a predictor of poor outcome; however, large trials of lowering blood pressure have given variable results, and the management of high b...
Journal: Journal of Neurology, Neurosurgery & Psychiatry
• March 2019
Antibodies against N-Methyl D-Aspartate Receptor (NMDAR) and other neuronal cell
surface targets are recognised associations of immunotherapy-responsive
autoimmune encephalitis. Initially patients p...
Journal: Social Psychiatry and Psychiatric Epidemiology
• March 2018
Purpose
There is consistent evidence that socio-environmental factors measured at an area-level, such as ethnic density, urban environment and deprivation are associated with psychosis risk. However,...
Journal: British Journal of Psychiatry
• March 2018
Background
Non-suicidal self-injury (NSSI) is highly prevalent in adolescents and may be a behavioural marker for emergent mental illnesses.
Aims
To determine whether sporadic or recurrent NSSI u...
Journal: Journal of Affective Disorders
• March 2018
Background
Catechol-O-methyltransferase (COMT) polymorphisms play an essential role in dopamine availability in the brain. However, there has been no study investigating whether a functional four-SNP...
Journal: Psychiatry Research
• March 2018
It is still unclear to what extent personality may influence the development of psychosis. We aimed to explore significant personality traits in individuals at high-risk (HR) for psychosis. Personalit...
Journal: Brain, Behavior, and Immunity
• March 2018
Objective
Interleukin 6 (IL-6) levels are commonly elevated in patients with depression and psychosis and in people who are at risk of developing these disorders. A common, functional variant in the...
Journal: Journal of the American College of Cardiology
• March 2017
Background: The alirocumab (ALI) ODYSSEY clinical trial program recruited patients with hypercholesterolemia, ∼70% of whom had atherosclerotic cardiovascular disease (ASCVD) and were at very high ASCV...
Journal: Schizophrenia Bulletin
• March 2017
Background: Childhood adversity and poor social support are implicated in the development of psychosis but have rarely been investigated together. This study investigated longitudinal relationships in...
Journal: Schizophrenia Bulletin
• March 2017
Background: Ethnic minorities have an increased risk of developing psychotic disorders, but the causes remain largely unknown. Theories such as social defeat have been suggested as possible explanator...
Journal: The Lancet Psychiatry
• March 2017
We thank Feras Mustafa, and Frank Leypoldt and colleagues for their comments on our study about the prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode p...
Journal: Psychological Medicine
• June 2023
Background
People with severe mental illness (SMI) have an elevated risk of obesity but the causes and mechanisms are unclear. We explored the familial association between parental SMI and body mass...
Journal: Nature Communications
• June 2021
Adolescents are prone to social influence from peers, with implications for development, both adaptive and maladaptive. Here, using a computer-based paradigm, we replicate a cross-sectional effect of...
Journal: Psychological Medicine
• June 2021
Background
Daily use of high-potency cannabis has been reported to carry a high risk for developing a psychotic disorder. However, the evidence is mixed on whether any pattern of cannabis use is asso...
Journal: Psychoneuroendocrinology
• June 2020
Background
Young adults with depression and evidence of inflammation may represent a high-risk group for cardiometabolic disorders, but studies of cardiometabolic risk in this population are scarce....
Journal: Counselling and Psychotherapy Research
• June 2020
Objectives
Mindfulness research in education has focused on its potential to support student well-being. There is a paucity of research on the interaction between mindfulness and academic performance...
Journal:
• June 2019
Background
Evidence is conflicting about a causal role of inflammation in psychosis and, specifically, regarding antibodies binding to neuronal membrane targets, especially N-methyl-D-aspartate recep...
Journal: Schizophrenia Research
• June 2019
Cross-sectional study of diet patterns in early and chronic schizophrenia Cross-sectional study of diet patterns in early and chronic schizophrenia Schizophr Res. 2019 Jun:208:451-453. doi: 10.1016/j....
Journal: Nature Neuroscience
• June 2019
The transition from adolescence to adulthood is a period when ongoing brain development coincides with a substantially increased risk of psychiatric disorders. The developmental brain changes accounti...
Journal: Schizophrenia Research
• June 2019
We investigated relationships between early developmental milestones, schizophrenia incidence and variability in its age at onset. We hypothesized that the period of risk for schizophrenia would be lo...
Journal: Psychological Medicine
• June 2019
Background
The value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate the transdiagnostic dimensional structure and...
Journal: Nature Neuroscience
• June 2019
A transition from adolescence into adulthood corresponds to a period where rapid brain development coincides with an enhanced incidence of psychiatric disorder. The precise developmental brain changes...
Journal: EP Europace
• June 2019
Funding Acknowledgements: Boston Scientific
Introduction: Remote patient monitoring (RPM) of implantable cardioverter-defibrillators (ICD) has been associated with reduced rates of all-cause rehosp...
Journal:
• June 2018
Background
There is an association between puberty and depression, but many things remain poorly understood. When assessing puberty in females, most studies combine indicators of breast and pubic hai...
Journal: Early Intervention in Psychiatry
• June 2018
Psychotic experiences, depressive and anxiety symptoms may be manifestations of a latent continuum of common mental distress. The Improving Access to Psychological Therapies (IAPT) programme has incre...
Journal: Human Brain Mapping
• June 2017
Early stressors play a key role in shaping interindividual differences in vulnerability to various psychopathologies, which according to the diathesis-stress model might relate to the elevated glucoco...
Journal: American Journal of Human Genetics
• June 2017
Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the common- and low-frequency spectra. We applied...
Journal: Children and Youth Services Review
• June 2017
The worldwide-pooled prevalence of mental disorders in children and adolescents is estimated at 13.4% (Polanczyk, Salum, Sugaya, Caye, & Rohde, 2015). In the UK one in ten children aged 5–16 years suf...
Journal: Early Intervention in Psychiatry
• June 2016
Aim
Early intervention programmes in mental illnesses started to bloom in the 1990s, and many programmes have been established worldwide during the past twenty years. However, the concept of early in...
Journal: European Neuropsychopharmacology
• June 2016
Though weight gain is a common side effect of antipsychotic treatment, there are no useful predictors of which patients are likely to be affected and to what degree. It has been shown that exposure to...
Journal: Applied Psychology: Health and Well-Being
• July 2020
Background
University students are expressing an increased need for mental health support. Mindfulness-based interventions (MBIs) are being integrated into university stress-reduction programmes glob...
Journal: Psychological Medicine
• July 2020
Background
To determine the baseline individual characteristics that predicted symptom recovery and functional recovery at 10-years following the first episode of psychosis.
Methods
AESOP-10 is a...
Journal: Australian & New Zealand Journal of Psychiatry
• July 2020
Objective:
Many people with psychotic experiences do not develop psychotic disorders, yet those who seek help demonstrate high clinical complexity and poor outcomes. In this systematic review and met...
Journal: Diabetes Therapy: Research, treatment and education of diabetes and related disorders
• July 2019
Cardiovascular disease (CVD), including heart failure (HF), is a leading cause of morbidity and mortality in people with type 2 diabetes mellitus (T2DM). CVD and T2DM share common risk factors for dev...
Journal: American Journal of Psychiatry
• July 2019
Objective:
Schizophrenia is associated with a marked cognitive impairment that is widely believed to remain stable after illness onset. Yet, to date, 10-year prospective studies of cognitive function...
Journal: Journal of Clinical Medicine
• July 2019
Evidence for early parental death as a risk factor for psychosis in offspring is inconclusive. We analyzed data from a six-country, case-control study to examine the associations of early parental dea...
Journal: Schizophrenia Bulletin
• July 2019
Development of schizophrenia relates to both genetic and environmental factors. Functional deficits in many cognitive domains, including the ability to communicate in social interactions and impaired...
Journal: Journal of Pathology: Clinical Research
• July 2018
We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was ass...
Journal: BMJ Open Quality
• July 2018
Reducing physical intervention in mental health inpatient care is a global priority. It is extremely distressing both to patients and staff. PROactive Management of Integrated Services and Environment...
Journal: Psychological Medicine
• July 2018
Background
To identify developmental sub-groups of depressive symptoms during the second decade of life, a critical period of brain development, using data from a prospective birth cohort. To test wh...
Journal: Monthly Notices of the Royal Astronomical Society
• July 2017
It is shown that the time variability inherent in the ion–proton polar cap leads naturally to the growth of Langmuir modes on narrow bundles of magnetic flux lines and that the observed size of microp...
Journal: bioRxiv
• July 2016
The transition from adolescence into adulthood is a period where rapid brain development coincides with an enhanced incidence of psychiatric disorder. The precise developmental brain changes that acco...
Journal: Monthly Notices of the Royal Astronomical Society
• July 2016
Evidence derived with minimal assumptions from existing published observations is presented to show that an ion–proton plasma is the source of radio-frequency emission in millisecond and in normal iso...
Journal: Schizophrenia Research
• July 2016
Aims
To investigate trajectories of negative symptoms during the first 12 months of treatment for first episode psychosis (FEP), their predictors and relationship to social recovery.
Method
1006 pa...
Journal: The Lancet
• July 2007
Background
Whether cannabis can cause psychotic or affective symptoms that persist beyond transient intoxication is unclear. We systematically reviewed the evidence pertaining to cannabis use and occ...
Journal: Schizophrenia Bulletin
• January 2021
Minor neurological signs are subtle deficits in sensory integration, motor coordination, and sequencing of complex motor acts present in excess in the early stages of psychosis. Still, it remains uncl...
Journal: Social Psychiatry and Psychiatric Epidemiology
• January 2020
Purpose
The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hyp...
Journal: American Journal of Psychiatry
• January 2020
Objective:
The authors investigated the incidence, course, and outcome of psychotic experiences from childhood through early adulthood in the general population and examined prediction of psychotic d...
Journal: Ophthalmic Epidemiology
• January 2020
Purpose: To compare severity of visual field (VF) loss at first presentation in glaucoma clinics in England and Tanzania.
Methods: Large archives of VF records from automated perimetry were used to...
Journal: Monthly Notices of the Royal Astronomical Society
• January 2020
A number of previous papers have developed an ion-proton theory of the pulsar polar cap. The basic equations summarizing this are given here with the results of sets of model step-to-step calculations...
Journal: The Lancet
• January 2019
Background
Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.
Methods
FOCUS was a...
Journal: Psychological Medicine
• January 2019
Background
Schizophrenia is associated with impaired neurodevelopment as indexed by lower premorbid IQ. We examined associations between erythrocyte sedimentation rate (ESR), a marker of low-grade sy...
Journal: Psychological Medicine
• January 2019
Background
Although school-based programmes for the identification of children and young people (CYP) with mental health difficulties (MHD) have the potential to improve short- and long-term outcomes...
Journal: Journal of Child Psychology and Psychiatry
• January 2018
Background
Non-suicidal self-injury (NSSI) is a common harmful behavior during adolescence. Exposure to childhood family adversity (CFA) is associated with subsequent emergence of NSSI during adolesc...
Journal: Neuron
• January 2018
Macroscopic cortical networks are important for cognitive function, but it remains challenging to construct anatomically plausible individual structural connectomes from human neuroimaging. We introdu...
Journal: Epidemiology & Infection
• January 2018
A link between infection, inflammation, neurodevelopment and adult illnesses has been proposed. The objective of this study was to examine the association between infection burden during childhood – a...
Journal: Cerebral Cortex
• January 2018
Motivated by prior data on local cortical shrinkage and intracortical myelination, we predicted age-related changes in topological organization of cortical structural networks during adolescence. We e...
Journal: The Lancet Psychiatry
• January 2018
Background
Provision of early intervention services has increased the rate of social recovery in patients with first-episode psychosis; however, many individuals have continuing severe and persistent...
Journal: JAMA Psychiatry
• January 2018
Importance Psychotic disorders contribute significantly to the global disease burden, yet the latest international incidence study of psychotic disorders was conducted in the 1980s.
Objectives To...
Journal: Brain, Behavior, and Immunity
• January 2017
Objective
Meta-analyses of cross-sectional studies confirm an increase in circulating inflammatory markers during acute psychosis. Longitudinal studies are scarce but are needed to understand whether...
Journal: The Lancet Psychiatry
• January 2017
Background
Psychosis is a common presenting feature in antibody-mediated encephalitis, for which prompt recognition and treatment usually leads to remission. We aimed to investigate whether people wi...
Journal: Psychiatry Research
• January 2017
This naturalistic study analysed the association between cumulative lifetime antipsychotic dose and cognition in schizophrenia after an average of 16.5 years of illness. Sixty participants with schizo...
Journal: Brain, Behavior, and Immunity
• January 2017
Objective
Meta-analyses of cross-sectional studies confirm an increase in circulating inflammatory markers during acute psychosis. Longitudinal studies are scarce but are needed to understand whether...
Journal: BMC Public Health
• January 2016
Background
Although sexual violence in war is associated with long-term mental health problems, little is known about its association with general functioning and the factors that explain this associ...
Journal: Biological Psychiatry
• February 2020
Background
In 2009, the National Institute of Mental Health launched the Research Domain Criteria, an attempt to move beyond diagnostic categories and ground psychiatry within neurobiological constru...
Journal: Human Brain Mapping
• February 2020
Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to...
Journal: Proceedings of the National Academy of Sciences of the United States of America
• February 2020
Adolescent changes in human brain function are not entirelyunderstood. Here, we used multiecho functional MRI (fMRI) tomeasure developmental change in functional connectivity (FC) ofresting-state osci...
Journal: Journal of Arrhythmia
• February 2020
Background
The ANZACS-QI Cardiac Implanted Device Registry (ANZACS-QI DEVICE) collects nationwide data on cardiac implantable electronic devices in New Zealand (NZ). We used the registry to describe...
Journal: Schizophrenia Research
• February 2020
Psychotic experiences (PE) co-occur with depression and anxiety, and indicate severity of general mental distress. Identifying PE in primary care mental health settings may facilitate access to eviden...
Journal: Brain, Behavior, and Immunity
• February 2019
Background
Low-grade inflammation is associated with depression, but studies of specific symptoms are relatively scarce. Association between inflammatory markers and specific symptoms may provide ins...
Journal: Schizophrenia Research
• February 2019
Background
The role of insight dimensions – illness recognition (IR), symptoms relabelling (SR), treatment compliance (TC) - in suicide risk in first-episode psychosis (FEP) remains unclear.
Method...
Journal: Schizophrenia Research
• February 2019
Background
Previous evidence suggests that delusional disorder has a later onset and better functional outcomes compared to schizophrenia. However, studies have not examined longitudinal outcomes in...
Journal: European Neuropsychopharmacology
• February 2019
Background: There is growing support for a hierarchical structure of first and higher-order dimensions of psychopathological symptoms, however, little is known about how these dimensions relate to gen...
Journal: Schizophrenia Research
• February 2019
Background:
The role of insight dimensions – illness recognition (IR), symptoms relabelling (SR),
treatment compliance (TC) - in suicide risk in first-episode psychosis (FEP) remains unclear.
Metho...
Journal: The Lancet Public Health
• February 2018
Background
The rising number of young people going to university has led to concerns about an increasing demand for student mental health services. We aimed to assess whether provision of mindfulness...
Journal: International Journal of Epidemiology
• February 2018
Mental and substance use disorders are the leading cause of years lived with disability, worldwide.1 Other than childhood developmental disorders and neurodegenerative dementias of the elderly, most m...
Journal: Monthly Notices of the Royal Astronomical Society
• February 2017
There is good evidence that electron–positron pair formation is not present in that section of the pulsar open magnetosphere, which is the source of coherent radio emission, but the possibility of two...
Journal: Social Psychiatry and Psychiatric Epidemiology
• February 2017
Purpose
Early Intervention Psychosis [EIP] services have gained traction internationally, but are currently undergoing various forms of reconfiguration. In England, such services are now mandated to...
Journal: The Lancet Psychiatry
• February 2017
Background
Evidence regarding the association between service contact and subsequent mental health in adolescents is scarce, and previous findings are mixed. We aimed to longitudinally assess the ext...
Journal: Design and Culture
• February 2017
The recent exhibition America in Revolt: The Art of Protest at Shapero Modern, a new gallery venture by the London bookseller Shapero Rare Books, featured fifty original posters and artwork produced b...
Journal: Proceedings of the National Academy of Sciences of the United States of America
• February 2016
How does human brain structure mature during adolescence? We used MRI to measure cortical thickness and intracortical myelination in 297 population volunteers aged 14–24 y old. We found and replicated...
Journal: Schizophrenia Research
• December 2024
We aimed to investigate long-term outcomes in psychotic major depression patients compared to schizophrenia and bipolar/manic psychosis patients, in an incidence sample, while accounting for diagnosti...
Journal: British Journal of Hospital Medicine
• December 2019
The incidence of psychotic disorders such as schizophrenia varies across person and place. We’ve known this since at least the 1930s, when Faris and Dunham demonstrated that rates were higher in inner...
Journal: The Lancet Diabetes and Endocrinology
• December 2019
Background
Odanacatib, a cathepsin K inhibitor, reduces bone resorption while maintaining bone formation. Previous work has shown that odanacatib increases bone mineral density in postmenopausal wome...
Journal: PLOS Computational Biology
• December 2018
Pavlovian influences are important in guiding decision-making across health and psychopathology. There is an increasing interest in using concise computational tasks to parametrise such influences in...
Acceptability of screening for mental health difficulties in primary schools: a survey of UK parents
Journal: BMC Public Health
• December 2018
Background
Many children and young people experiencing mental health difficulties (MHD) do not access care, often due to inadequate identification. Schools have a unique potential to improve early id...
Journal: Early Intervention in Psychiatry
• December 2018
Aim
The purpose of this paper is to review fidelity and outcome measures which can be used to support broad implementation of first episode psychosis services and ensure quality of existing services....
Journal: BMC Psychiatry
• December 2018
Background
Personality with stable behavioural traits emerges in the adolescent and young adult years. Models of putatively distinct, but correlated, personality traits have been developed to describ...
Journal: Indian Heart Journal
• December 2018
Background
The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the basel...
Journal: BMJ Case Reports
• December 2018
A 2-month-old girl with normal development and no previous physical illnesses was resuscitated having been found lifeless on her back at home. On admission to Paediatric Intensive Care, she had severe...
Journal: BMJ Open
• December 2018
Introduction Some people, who have common mental health disorders such as depression and anxiety, also have some psychotic experiences. These individuals may experience a treatment gap: their symptoms...
Journal: Schizophrenia Bulletin
• December 2017
Background
Urban birth and urban living are associated with increased risk of schizophrenia but less is known about effects on more common psychotic experiences (PEs). China has undergone the most ra...
Journal: Frontiers in Human Neuroscience
• December 2017
For millennia, humans have focused their attention on the breath to develop mindfulness, but finding a scientific way to harness mindful breathing has proven elusive. Existing attempts to objectively...
Journal: Thorax
• December 2016
Saliva has numerous practical advantages as a diagnostic bio-sample for management of long term conditions. We have previously demonstrated that C-reactive protein (CRP), procalcitonin (PCT) and neutr...
Journal: Early Intervention in Psychiatry
• December 2016
Aim
Early intervention (EI) in psychosis is a comprehensive and evidence-based approach aimed at detection and treatment of psychotic symptoms in their early stages. This paper presents core features...
Journal: Schizophrenia Research
• August 2020
Background
Schizophrenia is a complex disorder in which the causal relations between risk genes and observed clinical symptoms are not well understood and the explanatory gap is too wide to be clarif...
Journal: Biological Psychiatry
• August 2020
Background
Genetic risk is thought to drive clinical variation on a spectrum of schizophrenia-like traits, but the underlying changes in brain structure that mechanistically link genomic variation to...
Journal: Molecular Psychiatry
• August 2020
While comorbidity between coronary heart disease (CHD) and depression is evident, it is unclear whether the two diseases have shared underlying mechanisms. We performed a range of analyses in 367,703...
Journal: Scientific Reports
• August 2019
Understanding how variations in dimensions of psychometrics, IQ and demographics relate to changes in brain connectivity during the critical developmental period of adolescence and early adulthood is...
Journal: Early Intervention in Psychiatry
• August 2019
Aim
Duration of untreated psychosis (DUP) is considered as a key prognostic variable in psychosis. Yet, it is unclear whether a longer DUP causes worse outcomes or whether reported associations have...
Journal: Early Intervention in Psychiatry
• August 2019
Aim
Exploring how negative symptoms are experienced and understood by individuals with lived experience of psychosis has the potential to offer insights into the complex psychosocial processes underl...
Journal: European Neuropsychopharmacology
• August 2019
Computational psychiatry offers opportunities for increased mechanistic understanding of
mental disorder and to aid in the integration between psychiatry and neuroscience. By
developing and testing...
Minocycline for negative symptoms of schizophrenia and possible mechanistic actions: the BeneMin RCT
Journal: Efficacy and Mechanism Evaluation
• August 2019
Background
In a previous trial we reported that the neuroprotective, anti-inflammatory antibiotic minocycline lessened the negative symptoms of schizophrenia compared with placebo over 1 year. The Be...
Journal: Social Psychiatry and Psychiatric Epidemiology
• August 2018
Medicine of the mind, a highly interdisciplinary activity now known as psychiatry, was born in asylums concerned with the later stages of severe conditions that continue to shape even our most recent...
Journal: Translational Psychiatry
• August 2018
Whilst associations between polygenic risk scores (PRSs) for schizophrenia and various phenotypic outcomes have been reported, an understanding of developmental pathways can only be gained by modellin...
Journal: British Journal of Psychiatry
• August 2018
Background
The effectiveness of Early Intervention in Psychosis (EIP) services for individuals with a first episode of psychosis (FEP) could be thwarted by high rates of early disengagement.
Aims...
Journal: Early Intervention in Psychiatry
• August 2017
Aim
Early intervention services (EIS) for psychosis are being implemented, internationally. It is important to learn from established examples and define the components and intensity of services that...
Journal: Psychological Science
• August 2017
One of the most replicable findings in psychology is the positive manifold: the observation that individual differences in cognitive abilities are universally positively correlated. Investigating the...
Journal: European Heart Journal
• August 2017
Purpose: Atrial fibrillation (AF) burden and type of AF have not been established as major differential predictors of stroke and death. The aim of this work was to analyse outcomes by type of AF and b...
Journal: Journal of the American Society of Nephrology
• August 2017
Hyperinsulinemic hypoglycemia (HI) and congenital polycystic kidney disease (PKD) are rare, genetically heterogeneous disorders. The co-occurrence of these disorders (HIPKD) in 17 children from 11 unr...
Journal: Clinical Microbiology and Infection
• August 2017
Objectives
Left-sided methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis treated with cloxacillin has a poorer prognosis when the vancomycin minimum inhibitory concentration (MIC) is ≥...
Journal: Psychological Medicine
• August 2017
Background
We examined longitudinally the course and predictors of treatment resistance in a large cohort of first-episode psychosis (FEP) patients from initiation of antipsychotic treatment. We hypo...
Journal: British Journal of Psychiatry
• August 2017
Background
The incidence of psychotic disorders is elevated in some minority ethnic populations. However, we know little about the outcome of psychoses in these populations.
Aims
To investigate p...
Journal: Psychiatry Research: Neuroimaging
• August 2016
Antipsychotic medications and psychotic illness related factors may affect both weight and brain structure in people with psychosis. Genetically high-risk individuals offer an opportunity to study the...
Journal: British Journal of Haematology
• August 2016
Vitamin K antagonist (VKA) therapy for stroke prevention in atrial fibrillation (AF) requires monitoring of the international normalized ratio (INR). We evaluated the agreement between two INR audit p...
Journal: Comprehensive Psychiatry
• August 2016
Background
Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of a...
Journal: European Child & Adolescent Psychiatry
• August 2015
When adolescents with ADHD enter adulthood, some no longer meet disorder diagnostic criteria but it is unknown if biological and cognitive abnorma lities persist. We tested the hypothesis that people...
Journal: Psychological Medicine
• April 2020
Background
The ‘jumping to conclusions’ (JTC) bias is associated with both psychosis and general cognition but their relationship is unclear. In this study, we set out to clarify the relationship bet...
Journal: Schizophrenia Bulletin
• April 2020
Background
A number of psychological symptoms have been found to predict psychosis. Many studies have found no specificity to separate symptoms predicting non-psychotic psychiatric disorders from tho...
Journal: Schizophrenia Bulletin
• April 2020
Background
Cardiometabolic risk prediction algorithms are used in clinical practice. Young people with psychosis are a high-risk group for developing cardiometabolic disorders, but it is unclear whet...
Journal: Schizophrenia Bulletin
• April 2020
Background
Increasing evidence supports the benefits of regular aerobic exercise for cognition and functioning in schizophrenia. The extent to which these gains are dependent on the amount of aerobic...
Journal: Psychiatric Services
• April 2019
Objective:
The 333 model is a radical redesign of acute mental health care. Time-limited inpatient pathways for assessment (≤3 days), treatment (≤3 weeks), and recovery (≤3 months) replaced tradition...
Journal: bioRxiv
• April 2019
Adolescent changes in human brain function are not entirely understood. Here we used multi-echo functional magnetic resonance imaging (fMRI) to measure developmental change in functional connectivity...
Journal: Schizophrenia Bulletin
• April 2019
Background
Schizophrenia affects over 20 million people worldwide through a wide range of symptoms. As an incurable disorder, the disease management is normally based in antipsychotics, which may pre...
Journal: Schizophrenia Bulletin
• April 2019
Background
Importance: Associations between childhood infection, IQ and adult non-affective psychosis (NAP) are well established. However, examination of sensitive periods for exposure, effect of fam...
Journal: Schizophrenia Bulletin
• April 2019
Background
Subclinical metabolic dysfunction and inflammation have been associated with early psychosis and depression, suggesting the possibility of an intrinsic association. This may be due to shar...
Journal: Neuropsychopharmacology
• April 2018
Ongoing research suggests preliminary, though not entirely consistent, evidence of neural abnormalities in signalling prediction errors in schizophrenia. Supporting theories suggest mechanistic links...
Journal: Schizophrenia Bulletin
• April 2018
Background
Whilst associations between polygenic risk scores (PRSs) for schizophrenia and various phenotypic outcomes have been reported, an understanding of developmental pathways can only be gained...
Journal: Schizophrenia Bulletin
• April 2018
Background
Schizophrenia is associated with a severe cognitive impairment. While it is widely believed that cognitive deficits in schizophrenia remain stable after illness onset, few studies have com...
Journal: Schizophrenia Bulletin
• April 2018
Background
Altered immune response is associated with many psychiatric disorders, but whether and how these changes confer increased risk remains unclear. In schizophrenia, robust association between...
Journal: Schizophrenia Bulletin
• April 2018
Background
The validity of the classification of non-affective and affective psychoses as distinct entities has recently been disputed in light of calls for a dimensional and transdiagnostic approach...
Journal: Schizophrenia Bulletin
• April 2018
Background
Negative symptoms consist of impaired quality of life, social isolation, reduced emotional responsiveness, self-neglect and anhedonia, which have been categorised into avolition-apathy and...
Journal: Schizophrenia Bulletin
• April 2018
Background
Variable outcomes following a first-episode of psychosis are partly attributable to heterogeneity in cognitive functioning. Previous work in first episode psychosis has identified clinical...
Journal: Schizophrenia Bulletin
• April 2018
Background
Increasing our ability to identify youths at risk of psychosis in the general public is a key step towards an improved ability to prevent the disorder. Prospective evaluation of youths wit...
Journal: Schizophrenia Bulletin
• April 2018
Background
Little is known about patients with a first episode of psychosis (FEP) who had first presented to prodromal services with an “at risk mental state” (ARMS) before making the transition to p...
Journal: European Journal of Medical Genetics
• April 2018
The genetic association between autism spectrum disorder (ASD) and psychotic disorders such as schizophrenia is complicated and mirrors the clinical overlap between these conditions to some degree. Ho...
Journal: Psychiatry Research
• April 2018
Poor social functioning has been found to be present in those at risk for psychosis. This study aimed to examine metacognitive beliefs as potential predictors of structured activity (measure of social...
Journal: The Sixties
• April 2018
The exhibition, The British Underground Press of the Sixties, held at London’s A22 Gallery brought together some of the most important underground publications of the Sixties, such as International Ti...
Journal: Psychological Medicine
• April 2017
Accumulating evidence indicate a role for the immune system particularly inflammation and autoimmunity in the aetiology of major psychiatric disorders such as depression and schizophrenia. In this pap...
Journal:
• April 2017
Little is known about the underlying relationships between self-reported mental health items measuring both positive and negative emotional and behavioural symptoms at the population level in young pe...
Journal: Journal of Cardiothoracic and Vascular Anesthesia
• April 2017
Intensive care physicians are frequently required to make treatment decisions on behalf of patients who lack capacity. In the UK, these decisions are taken under the ‘best interests’ principle, unless...
Journal: British Journal of Psychiatry
• April 2017
Background
There is limited information on the presentation and characteristics of psychotic illness experienced by people with autism spectrum disorder (ASD).
Aims
To describe autistic and psych...
Journal: Journal of the American Heart Association
• April 2016
Background
Host factors and complications have been associated with higher mortality in infective endocarditis (IE). We sought to develop and validate a model of clinical characteristics to predict 6...
Journal: Translational Psychiatry
• April 2016
Serum levels of brain-derived neurotrophic factor (BDNF) are low in major depressive disorder (MDD), and were recently shown to decrease in chronic depression, but whether this is a trait or state mar...
Journal: Prosthetics and Orthotics International
• April 2016
Background:
Three-dimensional laser scanning has been used for patient measurement for cranial helmets and spinal braces. Ankle–foot orthoses are commonly prescribed for children with orthopaedic con...
Journal: BMJ Open
Objective To identify priorities for the delivery of community-based Child and Adolescent Mental health Services (CAMHS).
Design (1) Qualitative methods to gather public and professional opinions r...
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