Dr.(Prof.) Glyn Lewis

Background Peripheral low-grade inflammation in depression is increasingly seen as a therapeutic target. We aimed to establish the prevalence of low-grade inflammation in depression, using ...

Association of inflammation with symptoms that are commonly shared between psychiatric disorders may help to explain the apparent trans-diagnostic effect of inflammation, which is associated...

Although the association between low-grade inflammation and depression is well established, few studies have investigated this association at the symptom level. We studied the longitudinal a...

Background Low-grade inflammation is associated with depression, but studies of specific symptoms are relatively scarce. Association between inflammatory markers and specific symptoms may p...

Background: There is growing support for a hierarchical structure of first and higher-order dimensions of psychopathological symptoms, however, little is known about how these dimensions rel...

Inflammatory cytokines are commonly elevated in acute depression and are associated with resistance to monoaminergic treatment. To examine the potential role of cytokines in the pathogenesis...

Introduction Observational studies indicate a potentially causal role for interleukin 6 (IL-6), a proinflammatory cytokine, in pathogenesis of depression, but interventional studies based on...

Whilst associations between polygenic risk scores (PRSs) for schizophrenia and various phenotypic outcomes have been reported, an understanding of developmental pathways can only be gained b...

Background To identify developmental sub-groups of depressive symptoms during the second decade of life, a critical period of brain development, using data from a prospective birth cohort. ...

Background There is an association between puberty and depression, but many things remain poorly understood. When assessing puberty in females, most studies combine indicators of breast and...