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Cold Spring Harbor Laboratory
+1
jawaitted isssn
Monthly
2019
15163678800
YES
United States
English
YES
Google Scholar
libraryhelp@cshl.edu
Computational RNA design tasks are often posed as inverse problems, where sequences are designed based on adopting a single desired secondary structure without considering 3D geometry and co...
September, 2024
Motivation Computational models are crucial for addressing critical questions about systems evolution and deciphering system connections. The pivotal feature of making this concept recognisa...
June, 2024
Replication of influenza viral RNA depends on at least two viral polymerases, a parental replicase and an encapsidase, and cellular factor ANP32. ANP32 comprises an LRR domain and a long C-t...
April, 2024
Engineering enzyme biocatalysts for higher efficiency is key to enabling sustainable, green production processes for the chemical and pharmaceutical industry. This challenge can be tackled f...
High-throughput screening platforms for the profiling of drug sensitivity of hundreds of cancer cell lines (CCLs) have generated large datasets that hold the potential to unlock targeted, an...
Spatial transcriptomic technologies profile gene expression in-situ, facilitating the spatial characterisation of molecular phenomena within tissues, yet often at multi-cellular resolution. ...
Tissue homeostasis is maintained by the behaviours of lymphocyte clones responding to antigenic triggers in the face of pathogen, environmental, and developmental challenges. Current methodo...
Small molecules have been the preferred modality for drug development and therapeutic interventions. This molecular format presents a number of advantages, e.g. long half-lives and cell perm...
Adolescent changes in human brain function are not entirely understood. Here we used multi-echo functional magnetic resonance imaging (fMRI) to measure developmental change in functional con...
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