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About

I am interested in understanding human brain network organization from neuroimaging data in health and disease. My recent methodological work has focused on graph theory to measure aspects of brain network topology. I am also interested in better neuroscientific understanding and treatment of psychiatric disorders. I am currently leading a consortium funded by the Wellcome Trust and pharmaceutical companies (GSK, Janssen, Lundbeck) - the Neuroimmunology of Mood Disorders and Alzheimer's Disease (NIMA) consortium - which is exploring immune mechanisms and therapeutics for depression and dementia. Professor Ed Bullmore came to Cambridge as a Professor of Psychiatry in 1999, after undergraduate and graduate degrees at Oxford and King's College, London, where he played a prominent role at the Institute of Psychiatry. He is one of the most distinguished research psychiatrists in the UK with an international reputation. His research mainly involves the application of brain imaging to psychiatry. He has introduced an entirely original approach to the analysis of human brain anatomy, involving graph theory and its application to small world networks. This has had an enormous impact on the field, especially in relation to understanding the biological basis of schizophrenia and depression. His work has been key to the understanding of the 'wiring' of the human brain. He was Head of the Department of Psychiatry from 2014 – 2021 and is currently Deputy Head of the School of Clinical Medicine and Director of the Wolfson Brain Imaging Centre. He has been a Vice-President at GlaxoSmithKline, researching how anti-inflammatory drugs may be used in the treatment of psychiatric disorders. His popular science book "The Inflamed Mind: A Radical New Approach to Depression” was a Sunday Times bestseller.

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Skills

Experience

Head, Department of Psychiatry

University of Cambridge

Dec-1999 to Present
Chair, Cambridge Health Imaging

Cambridge University Health Partners (CUHP)

Dec-2014 to Dec-2024
Vice-President, Experimental Medicine and Head, Clinical Unit Cambridge

GSK

Dec-2005 to Dec-2024
Director, Research & Development

Cambridgeshire & Peterborough NHS Foundation Trust (CPFT)

Dec-2011 to Dec-2024
Advanced Research Training Fellow

Wellcome Trust

Dec-1996 to Dec-1999
Wellcome Trust Research Training Fellow

Wellcome Trust

Dec-1993 to Dec-1995

Education

University of London (UL)

Ph.D. in Statistics of brain image analysis

Passout Year: 1997
University of Oxford

B.A in Physiological Sciences

Passout Year: 1981

Publication

Acute effects of interferon-alpha on cellular anabolic and catabolic processes are associated with the development of fatigue during Interferon-alpha-...

Introduction Interferon-alpha (IFN-α) is a key mediator of antiviral immune responses used to treat Hepatitis-C virus (HCV) infection. Though clinically effective, IFN-α frequently induce...

Research Article
  • dott image Sarah Morgan
  • dott image January, 2025

Structural MRI of brain similarity networks

Recent advances in structural MRI analytics now allow the network organization of individual brains to be comprehensively mapped through the use of the biologically principled metric of anat...

Extra-axial inflammatory signal and its relationship to peripheral and central immunity in depression

Although both central and peripheral inflammation have been observed consistently in depression, the relationship between the two remains obscure. Extra-axial immune cells may play a role in...

Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations

Post-mortem studies have shown that patients dying from severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection frequently have pathological changes in their CNS, particularly i...

Disorders of compulsivity: a common bias towards learning habits

Why do we repeat choices that we know are bad for us? Decision making is characterized by the parallel engagement of two distinct systems, goal-directed and habitual, thought to arise from t...

A bimodal taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients

We developed a computational pipeline (now provided as a resource) for measuring morphological similarity between cortical surface sulci to construct a sulcal phenotype network (SPN) from ea...

Evaluating Models of the Ageing BOLD Response

Neural activity cannot be directly observed using fMRI; rather it must be inferred from the hemodynamic responses that neural activity causes. Solving this inverse problem is made possible t...

Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduct...

The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We repo...

Brain, lifestyle and environmental pathways linking physical and mental health

Depression and anxiety are prevalent in people with a chronic physical illness. Increasing evidence suggests that co-occurring physical and mental illness is associated with shared biologica...

Research Article
  • dott image Richard A.I. Bethlehem
  • dott image April, 2022

Brain charts for the human lifespan

Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify in...

Invited Position

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A New Approach to Depression

University of Cambridge

From year 2018 to 2018

https://www.youtube.com/watch?v=I9DofDwJfyQ

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CSAR

University of Cambridge

From year 2019 to 2019

https://www.youtube.com/watch?v=Gz-qbvqQBu4

Patent

  • dott image Medical & Health Science
Methods for assessing psychotic disorders
Assignee:

Cambridge Enterprise Ltd

Filing Country:

United States

Filing Month:

May 2005

Application No:

US11/990,825

Patent No:

US20090136423A1

Publication status:

Published

Publication Date:

May 2008

Inventor(s): Barbara Sahakian, Edward Bullmore, Jennifer Barnett, Peter Jones