Emelia J. Benjamin
Professor of Medicine and Epidemiology
at Boston University Chobanian & Avedisian School of Medicine
📚 Cardiologist at Boston Medical Center (BMC)
|
Boston, Massachusetts, United States
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👤 About
Emelia J. Benjamin, MD, ScM, is a board-certified cardiologist at Boston Medical Center (BMC) and a Robert Dawson Evans Distinguished Professor of Medicine at Boston University Chobanian & Avedisian School of Medicine. She is also the associate provost for faculty development for Boston University Medical Campus. Dr. Benjamin has authored more than 800 peer-reviewed publications on the genetics, epidemiology, and prognosis of a variety of cardiovascular conditions. A passionate and dedicated mentor, she has won local and national awards for mentoring, education, and research, and she is an active volunteer for the American Heart Association.
Emelia J. Benjamin, MD, ScM, FACC, FAHA, received her AB at Harvard, her MD at Case Western Reserve University, and her Epidemiology ScM at Harvard School of Public Health. She is a Professor of Medicine and Epidemiology at Boston University and is a cardiologist at Boston Medical Center. She is a Robert Dawson Evans Distinguished Professor of Medicine at Chobanian and Avedisian School of Medicine.
She is author of over 800 peer-reviewed publications that focus on the genetics, epidemiology, and prognosis of a variety of cardiovascular conditions and markers including atrial fibrillation, vascular function, and systemic inflammation. She has been continuously NIH funded since 1998, and currently is multi-Principal Investigator on an R01 atrial fibrillation grant [2R01HL092577], several chronic pain grants, and is the Training Director on the Boston University American Heart Association Strategically Focused Research Network on Cardio-Oncology. She is an internationally recognized expert on the epidemiology of atrial fibrillation. Dr. Benjamin has Co-Chaired the NIH National Heart Lung and Blood Institutes’ (NHLBI) Atrial Fibrillation Working Group, which advised the NHLBI’s atrial fibrillation research agenda, and resulted in 6 publications.
Dr. Benjamin has conducted research at the Framingham Study since 1988. She is a Member of the Executive Committee, and is Co-Director of the Medical Endpoints Committee. She was Principal Investigator of the grant that recruited the second generation of the Framingham Study's ethnic/racial minority cohort, the Omni Study.
In addition to her research, she is the inaugural Associate Provost for Faculty Development for Boston University Medical Campus, and the inaugural Vice Chair for Faculty Development and Diversity, BU Department of Medicine. She co-designed and co-leads Faculty Development Programs for Early, Mid-Career, Under-Represented Ethnic and Racial, Women, and Clinical Leaders. In 2023 she completed the Columbia University Advanced Coaching Certification.
A passionate and dedicated mentor, she has won local and national awards for mentoring, education, and research. She was inducted into the Association of American Physicians and she won the 2020 Alliance for Academic Internal Medicine Diversity, Equity, and Inclusion Award.
An active volunteer for the American Heart Association since 1992, she has served on a variety of local and national Committees. She is Past-Chair of the American Heart Association’s Functional Genomics and Translational Biology Council and Study Section, and the annual Heart and Stroke Statistical Update. She received the 2015 Paul Dudley White Award, the 2016 AHA Gold Heart Award, the 2016 Population Research Prize, the 2019 Laennec Clinician/ Educator Lecturer, and the Genomics and Precision Medicine 2019 Distinguished Achievement Award, and the 2022 Distinguished Scientist Award.
Skills & Expertise
Public Health
Medicine
Cardiovascular Disease
Research Leadership
Precision Medicine in Cardiology
Grant Acquisition
Cardiovascular Genetics
Atrial Fibrillation
Chronic Pain Research
Diversity Initiatives
Clinical Education
Research Interests
Epidemiology
Faculty Development
Diversity issues
Prevention
Precision Medicine
cardiovascular disease
Inflammation
cardiologist
atrial fibrillation
vascular function
cardiovascular prevention
Internal Medicine
Cardiovascular Epidemiology
Atrial Fibrillation
Genetics of Cardiovascular Disease
Cardio-Oncology Research
Chronic Pain Research
Mentoring in Medicine
NIH-Funded Research
Vascular Function
Systemic Inflammation
Translational Genomics
Clinical Leadership Development
Atrial fibrillation
Vascular function
Connect With Me
💼 Experience
Professor of Medicine and Epidemiology
Boston University Chobanian & Avedisian School of Medicine
·
July 1990 -
Present
Director of Echocardiography and Vascular Testing
Framingham Heart Study (FSH)
·
July 1998 -
January 2025
- Present the Framingham Heart Study is a longitudinal community-based 3-generation observational cohort study founded in 1948 to study the epidemiology, risk factors and prognosis of cardiovascular disease.
Vice Chair Faculty Development & Diversity
Boston University Chobanian & Avedisian School of Medicine
·
January 1990 -
January 2025
- Present
Assistant Provost for Faculty Development
Boston University Chobanian & Avedisian School of Medicine
·
August 2015 -
January 2025
- Present
Cardiology Fellow
Boston University Chobanian & Avedisian School of Medicine
·
July 1986 -
January 1988
🎓 Education
Harvard T.H. Chan School of Public Health, Boston
ScM in
Epidemiology
· 2000
School of Medicine, Case Western Reserve University
M.D. in
Medicine
· 1983
Harvard University
AB in
Psychology and Social Relations
· 1979
🚀 Projects
ENDOTHELIAL VASAMOTOR FUNCTION IN THE FRAMINGHAM STUDY
Agency Name: National Heart, Lung, and Blood Institute (Bethesda, US) ||
Dec 1998 - Nov 2003
Funded: Yes ||
Amount: USD 595,086
INFLAMMATION: CORRELATES AND PROGNOSIS IN FRAMINGHAM
Agency Name: National Heart, Lung, and Blood Institute (Bethesda, US) ||
July 2000 - June 2004
Funded: Yes ||
Amount: USD 1,154,395
Vascular Function in the Framingham Third Generation
Agency Name: National Heart, Lung, and Blood Institute (Bethesda, US) ||
May 2002 - March 2007
Funded: Yes ||
Amount: USD 2,396,612
Framingham: Inflammation, Genes &Cardiovascular Disease
Agency Name: National Heart, Lung, and Blood Institute (Bethesda, US) ||
June 2004 - may 2010
Funded: Yes ||
Amount: USD 3,941,014
Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study
Agency Name: National Institute on Aging (Bethesda, US) ||
Sep 2006 - June 2012
Funded: Yes ||
Amount: USD 1,761,043
Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval
Agency Name: National Heart, Lung, and Blood Institute (Bethesda, US) ||
April 2008 - March 2018
Funded: Yes ||
Amount: USD 12,760,142
Risk prediction of atrial fibrillation: clinical, biological and genetic markers
Agency Name: National Heart, Lung, and Blood Institute (Bethesda, US) ||
Sep 2009 - July 2012
Funded: Yes ||
Amount: USD 967,223
Patterns of Health Care Use, Treatment &Outcomes in Atrial Fibrillation: PATH-AF
Agency Name: National Heart, Lung, and Blood Institute (Bethesda, US) ||
May 2010 - April 2014
Funded: Yes ||
Amount: USD 1,401,070
RESEARCH TRAINING AND EDUCATION CORE (CORE D)
Agency Name: NHLBI (Bethesda, MD, NIH, US) ||
Sep 2013 - June 2018
Funded: Yes ||
Amount: USD 357,777
AFGen Consortium: Atrial Fibrillation Genomics to Functional Analyses
Agency Name: National Heart, Lung, and Blood Institute (Bethesda, US) ||
August 2015 - May 2019
Funded: Yes ||
Amount: USD 772,406
Advancing Atrial Fibrillation Precision Medicine
Agency Name: American Heart Association (Dallas, US) ||
July 2018 - June 2022
Funded: Yes ||
Amount: USD 712,285
Our proposed AHA SFRN Center is entitled "Advancing Atrial Fibrillation Precision Medicine (AAFPM) Center." The AAFPM Center represents 3 interrelated translational projects submitted by a highly collaborative research team with an extraordinarily productive ten-year record of international leadership in atrial fibrillation (AF) research. The Basic Project will further our understanding of the genetic predisposition to AF in ethnic/racial minorities and the molecular underpinnings of top genetic risk loci. The Clinical Project will develop and implement a rational and personalized approach to AF risk estimation that can inform management decisions by combining clinical and genetic risk factors in patients with ischemic stroke. The Population Project will develop models for lifetime risk of AF based on clinical and genetic factors, and subsequently will examine the lifetime risk of complications in individuals with AF. The three projects together will advance our understanding of the genetic and environmental risks and burden of clinically recognized AF and unrecognized AF in the community. Furthermore, we propose to sponsor a Cross-Center AF SFRN Virtual Fellowship to accelerate synergy and collaborations across Centers and Disciplines to train the next generation of translational AF scientists and further the mission of the American Heart Association.
🏅 Certificates & Licenses (1)
Certificate of Achievement for the Front-end Coaching Intensive (FECI)
Event: Certificate of Achievement for the Front-end Coaching Intensive (FECI) ·
Columbia Coaching Center of Excellence (CCOE) · Issued on December 2022
https://www.credly.com/badges/338f120e-f238-48a5-a983-8034ed060f8f/linked_in_profile
Columbia Coaching Center of Excellence (CCOE) is a strategic partnership between Teachers College and the Columbia Business School. FECI focuses on learning and applying 3 foundations (i.e., 4 guiding principles and 4 of 9 core coaching competencies, embedded in a comprehensive 3-phased process - FECI addresses 7 of 9 coaching components) that comprise the Columbia Approach to Executive and Organizational Coaching. FECI is a 5-day intensive offered for 4.2 Continuing Education Units (CEUs).
🏆 Awards & Achievements (19)
🏆 Wendy Kline Memorial Award for Outstanding Volunteer Leadership
Awarded by: American Heart Association, Boston Division || Year:
2001
Description
🏆 Great Communicator Award
Awarded by: American Heart Association, New England Affiliate || Year:
2002
Description
🏆 Elected Member
Awarded by: Association of University Cardiologists || Year:
2008
Description
🏆 Excellence in Research Mentoring Award
Awarded by: BUSM, Department of Medicine || Year:
2011
Description
🏆 Dr. Daniel D. Savage Memorial Science Award
Awarded by: Association of Black Cardiologists, Inc || Year:
2012
Description
🏆 Functional Genomics and Translational Biology Mentoring Award
Awarded by: American Heart Association || Year:
2013
Description
🏆 Joel G. Caslowitz, MD Award for Excellence in Teaching–Hospital
Awarded by: BUSM, Department of Medicine || Year:
2015
Description
🏆 Paul Dudley White Award
Awarded by: American Heart Association || Year:
2015
Description
🏆 Population Scientist of the Year
Awarded by: American Heart Association || Year:
2016
Description
🏆 Gold Heart Award
Awarded by: American Heart Association || Year:
2016
Description
🏆 Distinguished Achievement, GPM Council
Awarded by: American Heart Association || Year:
2019
Description
🏆 Laennec Clinician/ Educator Lecturer
Awarded by: American Heart Association || Year:
2019
Description
🏆 Association of American Physicians, Inductee
Awarded by: Association of American Physicians || Year:
2021
Description
🏆 Robert Dawson Evans Distinguished Professor of Medicine
Awarded by: BUSM, Department of Medicine || Year:
2021
Description
🏆 Distinguished Scientist Award
Awarded by: American Heart Association || Year:
2022
Description
🏆 Diversity, Equity, and Inclusion Award
Awarded by: Alliance for Academic Internal Medicine || Year:
2020
Description
🏆 Women in Cardiology Mentoring Award
Awarded by: American Heart Association, National Clinical Cardiology Council || Year:
2012
Description
🏆 Dr. Daniel D. Savage Memorial Science Award
Awarded by: Association of Black Cardiologists || Year:
2012
Description
🏆 Gender Equity Award
Awarded by: American Medical Women’s Association || Year:
1995
Description
Professional Memberships (1)
American Heart Association (AHA)
Member: Chair, AHA Cardiovascular Epidemiology Council, Statistics Committee || Join dt:
2015 - Present
Country: United States
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📚 Publications (273)
Journal: The Journals of Gerontology-Series A Biological sciences and medical sciences
• September 2014
Background.
The genetic contribution to longevity in humans has been estimated to range from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with longevity in multiple independent...
Journal: JACC: Cardiovascular Imaging
• September 2014
Objectives:
This study sought to evaluate pattern and clinical correlates of change in left ventricular (LV) geometry over a 4-year period in the community; it also assessed whether the pattern of ch...
Journal: Journal of the American Medical Association
• September 2012
Context Vascular stiffness increases with advancing age and is a major risk factor for age-related morbidity and mortality. Vascular stiffness and blood pressure pulsatility are related; however, temp...
Journal: Circulation
• September 2012
Atrial fibrillation (AF) is a highly prevalent and costly health problem, with an estimated incidence of 28 per 1000 person-years in the United States and an incremental national cost of $26 billion.1...
Journal: Circulation
• September 2012
Background—
Atrial fibrillation is common among older persons. Catheter ablation is increasingly used in patients for whom medical therapy has failed.
Methods and Results—
We conducted a retrospect...
Journal: American Journal of Human Genetics
• September 2012
Rare sarcomere protein variants cause dominant hypertrophic and dilated cardiomyopathies. To evaluate whether allelic variants in eight sarcomere genes are associated with cardiac morphology and funct...
Journal: Nature
• September 2011
Blood pressure is a heritable trait1 influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood p...
Journal: Circulation
• September 2010
Background—
Systolic blood pressure and pulse pressure are substantially higher in older adults. The relative contributions of increased forward versus reflected pressure wave amplitude or earlier ar...
Journal: Circulation
• September 2009
The AHA/ACCF Primary Prevention of Cardiovascular Disease Performance Measures Writing Committee (the Writing Committee) was charged to develop performance measures for the prevention of CVD. These pe...
Journal: Journal of the American Society of Nephrology
• September 2009
Whether arterial stiffness correlates with mild-to-moderate CKD and albuminuria in the community is unclear. We studied the association between arterial stiffness and mild-to-moderate CKD and albuminu...
Journal: BMC Medical Genetics
• September 2007
Background
Cardiovascular disease (CVD) and its most common manifestations – including coronary heart disease (CHD), stroke, heart failure (HF), and atrial fibrillation (AF) – are major causes of mor...
Journal: BMC Medical Genetics
• September 2007
Background
Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span.
Methods
We conducted a genome wide association study (Affymet...
Journal: BMC Medical Genetics
• September 2007
Background
The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the w...
Journal: Clinical Diabetology
• September 2007
Data are limited regarding prevalence and prognostic significance of subclinical cardiovascular disease (CVD) in individuals with metabolic syndrome. We investigated prevalence of subclinical CVD in 1...
Journal: Psychosomatic medicine
• September 2005
Objective:
Conflicting research findings regarding the ability of tension or anxiety to predict incident coronary heart disease (CHD) have created uncertainty in the literature. In addition, there a...
Journal: Journal of the American Geriatrics Society
• September 2005
Objectives: To examine whether midlife cardiovascular risk factors predict survival and survival free of major comorbidities to the age of 85.
Design: Prospective community-based cohort study.
S...
Journal: Psychosomatic medicine
• September 2005
Objective
Although a substantial number of studies have shown that depressive symptoms predict worse cardiac outcome for patients with existing coronary disease, relatively few methodologically rigor...
Journal: European Heart Journal
• September 2004
Aims Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a key regulator of extracellular matrix degradation. We examined relations of plasma total TIMP-1 to cardiovascular risk factors and echocardi...
Journal: The New England Journal of Medicine
• September 2002
Background
Little is known about the epidemiology and prognosis of syncope in the general population.
Methods
We evaluated the incidence, specific causes, and prognosis of syncope among women and m...
Journal: Journal of the American Medical Association
• September 2002
ontext Several reports have suggested the usefulness of plasma brain natriuretic peptide (BNP) as a screening test for left ventricular hypertrophy (LVH) and systolic dysfunction (LVSD). Prior studies...
Journal: Circulation
• September 1998
Background—Atrial fibrillation (AF) causes substantial morbidity. It is uncertain whether AF is associated with excess mortality independent of associated cardiac conditions and risk factors.
Methods...
Journal: Circulation
• September 1997
Background Despite widespread categorization of echocardiographic measurements, there are no standardized guidelines for partitioning values exceeding reference limits.
Methods and Results We used re...
Journal: Stroke
• September 1995
Background and Purpose When atrial fibrillation (AF) is first documented at the time of onset of acute stroke, it is difficult to establish a temporal relationship between AF and stroke. Did AF preced...
Journal: EP Europace
• October 2014
Aims
B-type natriuretic peptide (BNP) and C-reactive protein (CRP) predict atrial fibrillation (AF) risk. However, their risk stratification abilities in the broad community remain uncertain. We soug...
Journal: Journal of the American Heart Association
• October 2014
Background
Dyslipidemia is a major contributor to the development of atherosclerosis and coronary disease. Its role in the etiology of atrial fibrillation (AF) is uncertain.
Methods and Results
We...
Journal: The New England Journal of Medicine
• October 2012
Background
There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events.
Methods
We analyze...
Journal: Diabetes Care
• October 2010
OBJECTIVE—Systemic oxidative stress causes insulin resistance in rodents. We tested the hypothesis that oxidative stress and insulin resistance are associated in humans.
RESEARCH DESIGN AND METHODS...
Journal: Circulation
• October 2010
Background—
Several biological pathways are activated in ventricular remodeling and in overt heart failure (HF). There are no data, however, on the incremental utility of a parsimonious set of biomar...
Journal: The New England Journal of Medicine
• October 2002
Background
Heart failure is a major public health problem. Long-term trends in the incidence of heart failure and survival after its onset in the community have not been characterized.
Methods
We u...
Journal: Diabetes Care
• October 2002
OBJECTIVE—To test the hypothesis that fasting hyperglycemia (FHG) and 2-h postchallenge glycemia (2hPG) independently increase the risk for cardiovascular disease (CVD).
RESEARCH DESIGN AND METHODS...
Journal: Journal of the American College of Cardiology
• October 2002
Objectives:
The aim of this study was to examine the echocardiographic features and associations of mitral valve prolapse (MVP) diagnosed by current two-dimensional echocardiographic criteria in an u...
Journal: American Journal of Cardiology
• October 1998
Atrial fibrillation (AF) is the most common of the serious cardiac rhythm disturbances and is responsible for substantial morbidity and mortality in the general population. Its prevalence doubles with...
Journal: Stroke
• October 1996
Background and Purpose Stroke occurring with atrial fibrillation (AF) is more likely to be fatal or more severe than non-AF stroke based on clinical series, but data from prospective epidemiological s...
Journal: Circulation
• November 2023
Background— Information is limited regarding the rates of progression to congestive heart failure (CHF) and death in individuals with asymptomatic left ventricular systolic dysfunction (ALVD). We soug...
Journal: Nature Genetics
• November 2021
Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of sudden death. We trained a deep learning model to evaluate the dimensions of the ascending and descending thoracic...
Journal: American Journal of Human Genetics
• November 2018
Inflammation plays a key role in the development of complex diseases, such as cardiovascular disease,1 type 2 diabetes,2 Alzheimer disease,3 and schizophrenia.4 C-reactive protein (CRP) is a sensitive...
Journal: Circulation
• November 2017
Background:
The long-term probability of developing atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden is unknown.
Methods:
We estimated the lifetime risk o...
Journal: JAMA Internal Medicine
• November 2017
Importance Gamification, the application of game design elements such as points and levels in nongame contexts, is often used in digital health interventions, but evidence on its effectiveness is lim...
Journal: Journal of the American Heart Association
• November 2015
Background
Arterial stiffness, pressure pulsatility, and wave reflection are associated with cardiovascular disease. Left ventricular function is coupled to proximal aortic properties, but the associ...
Journal: Chest
• November 2014
BACKGROUND
New-onset atrial fibrillation (AF) is associated with adverse outcomes during a sepsis hospitalization; however, long-term outcomes following hospitalization with sepsis-associated new-ons...
Journal: European Heart Journal
• November 2013
Aims
Atrial fibrillation increases the risks of stroke, heart failure, and death, and anticoagulation therapy increases the risk of gastrointestinal haemorrhage. However, the relative event rates for...
Journal: Circulation
• November 2012
Background—
Low serum magnesium has been linked to increased risk of atrial fibrillation (AF) after cardiac surgery. It is unknown whether hypomagnesemia predisposes to AF in the community.
Methods...
Journal: Circulation
• November 2011
Since the 2006 update of the American Heart Association (AHA)/American College of Cardiology Foundation (ACCF) guidelines on secondary prevention,1 important evidence from clinical trials has emerged...
Journal: Circulation
• November 2011
The recommendations listed in this document are, whenever possible, evidence based. An extensive evidence review was conducted through January 2011. Searches were limited to studies, reviews, and othe...
Journal: Circulation
• November 2011
The medical profession should play a central role in evaluating the evidence related to drugs, devices, and procedures for the detection, management, and prevention of disease. When properly applied,...
Journal: Journal of the American Medical Association
• November 2011
Context New-onset atrial fibrillation (AF) has been reported in 6% to 20% of patients with severe sepsis. Chronic AF is a known risk factor for stroke and death, but the clinical significance of new-o...
Journal: Circulation
• November 2011
Atrial fibrillation (AF) is of public health importance and profoundly increases morbidity, mortality, and health-related expenditures. Morbidities include the increased risks of cardiovascular outcom...
Journal: Neurobiology of aging
• November 2011
Human longevity and healthy aging show moderate heritability (20%–50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in...
Journal: American Journal of Cardiology
• November 2011
Heart failure is a risk factor for Alzheimer's disease and cerebrovascular disease. In the absence of heart failure, it was hypothesized that left ventricular ejection fraction (LVEF), an indicator of...
Journal: Journal of the American Medical Association
• November 2010
Context Although the heritability of atrial fibrillation (AF) is established, the contribution of familial AF to predicting new-onset AF remains unknown.
Objective To determine whether familial occ...
Journal: Circulation
• November 2010
Background—
Despite a higher burden of standard atrial fibrillation (AF) risk factors, African Americans have a lower risk of AF than whites. It is unknown whether the higher risk is due to genetic o...
Journal: Circulation: Heart Failure
• November 2010
Background—
The high mortality rate in patients with heart failure (HF) is influenced by presence of multiple comorbidities. Data are limited on the relative contributions of cardiovascular versus no...
Journal: Archives of Internal Medicine
• November 2010
Background We sought to validate a recently published risk algorithm for incident atrial fibrillation (AF) in independent cohorts and other racial groups.
Methods We evaluated the performance of...
Journal: Atherosclerosis
• November 2008
Aims
We sought to investigate the hypothesis that smoking is accompanied by systemic inflammation.
Methods and results
We examined the relation of smoking to 11 systemic inflammatory markers in Fra...
Journal: American Journal of Epidemiology
• November 2007
In vitro data suggest protective roles for vitamins K and D in inflammation. To examine associations between vitamins K and D and inflammation in vivo, the authors used multiple linear regression anal...
Journal: BMC Medical Genetics
• November 2007
ackground
About one quarter of adults are hypertensive and high blood pressure carries increased risk for heart disease, stroke, kidney disease and death. Increased arterial stiffness is a key factor...
Journal: European journal of clinical nutrition
• November 2007
Objective:
To assess the genetic and nongenetic correlates of circulating measures of vitamins K and D status in a community-based sample of men and women.
Subjects/Methods:
A cross-sectional stu...
Journal: Archives of Internal Medicine
• November 2005
Background Determination of C-reactive protein (CRP) level has been suggested to improve cardiovascular disease (CVD) risk assessment. This study examines the utility of CRP levels to assess CVD risk...
Journal: Journal of the American Medical Association
• November 2004
Context Obesity is associated with atrial enlargement and ventricular diastolic dysfunction, both known predictors of atrial fibrillation (AF). However, it is unclear whether obesity is a risk factor...
Journal: Circulation
• November 2004
Background— In experimental studies, traditional risk factors and proinflammatory processes alter the regulatory functions of the vascular endothelium to promote atherosclerosis. These alterations inc...
Journal: Circulation
• November 2002
Background— Congestive heart failure (CHF) is an increasing public health problem.
Methods and Results— Among Framingham Heart Study subjects who were free of CHF at baseline, we determined the lifet...
Journal: American Journal of Cardiology
• November 1999
Atrial fibrillation (AF) is the most common sustained arrhythmia, affecting an estimated 2.2 million adults in the United States. The median age of people with AF is 75, and it affects 8.8% of the US...
Journal: Journal of the American College of Cardiology
• November 1998
Objectives. This study examined the relations of echocardiographically determined left ventricular (LV) mass and hypertrophy to the risk of sudden death.
Background. Echocardiographic LV hypertrophy...
Journal: The New England Journal of Medicine
• November 1994
Background
Low serum thyrotropin concentrations are a sensitive indicator of hyperthyroidism but can also occur in persons who have no clinical manifestations of the disorder. We studied whether low...
Journal: Nature Reviews Cardiology
• May 2019
The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors fo...
Journal: Circulation
• May 2017
Approximately 10% of ischemic strokes are associated with atrial fibrillation (AF) first diagnosed at the time of stroke. Detecting asymptomatic AF would provide an opportunity to prevent these stroke...
Journal: American Heart Journal
• May 2014
Background
Galectin 3 (Gal-3) is a potential mediator of cardiac fibrosis, and Gal-3 concentrations predict incident heart failure. The same mechanisms that lead to cardiac fibrosis in heart failure...
Journal: Circulation
• May 2012
Background—
Exercise blood pressure (BP) is an important marker of left ventricular hypertrophy, incident hypertension, and future cardiovascular events. Although impaired vascular function is hypoth...
Journal: The Lancet
• May 2010
Background
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an inflammatory enzyme expressed in atherosclerotic plaques, is a therapeutic target being assessed in trials of vascular disease pre...
Journal: Circulation: Cardiovascular Genetics
• May 2010
Background—
Although genetic factors contribute to the onset of heart failure (HF), no large-scale genome-wide investigation of HF risk has been published to date. We have investigated the associatio...
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology
• May 2010
Objective— Experimental evidence identified the osteoprotegerin (OPG)/receptor activator of nuclear factor–κB (RANK)/RANK ligand (RANKL) pathway as a candidate system modulating vascular remodeling an...
Journal: The Journals of Gerontology-Series A Biological sciences and medical sciences
• May 2010
Background.
Genome-wide association studies (GWAS) may yield insights into longevity.
Methods.
We performed a meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Ge...
Journal: Nature Genetics
• May 2009
Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results...
Journal: Nature Genetics
• May 2009
Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity1. We conducted genome-wide association studies (GWA...
Journal: Circulation
• May 2008
Background— Digital pulse amplitude augmentation in response to hyperemia is a novel measure of peripheral vasodilator function that depends partially on endothelium-derived nitric oxide. Baseline dig...
Journal: Circulation
• May 2008
Background— Whether sleep-disordered breathing (SDB) is a risk factor for left ventricular (LV) hypertrophy and dysfunction is controversial. We assessed the relation of SDB to LV morphology and systo...
Journal: Neurology
• May 2007
Objective: To examine whether serum cytokines and spontaneous production of peripheral blood mononuclear cell (PBMC) cytokines are associated with the risk of incident Alzheimer disease (AD).
Methods...
Journal: Circulation
• May 2007
Background— Increased aortic stiffness is associated with numerous common diseases of aging, including heart disease, stroke, and renal disease. However, the prevalence and correlates of abnormally hi...
Journal: Circulation
• May 2006
Since the 2001 update of the American Heart Association (AHA)/American College of Cardiology (ACC) consensus statement on secondary prevention,1 important evidence from clinical trials has emerged tha...
Journal: Hypertension
• May 2004
With advancing age, arterial stiffness and wave reflections increase and elevate systolic and pulse pressures. An elevated central pulse pressure is generally ascribed to increased wave reflection and...
Journal: American Journal of Epidemiology
• May 2004
Conflicting findings in the literature have made the relation between job strain and coronary heart disease (CHD) controversial. The effect of high job strain on the 10-year incidence of CHD and total...
Journal: Circulation
• May 2003
Background— Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of the...
Journal: Circulation
• May 2001
Abstract—This is Part II of a 2-part article dealing with malignant ventricular arrhythmias, which are the leading mechanism of death in common cardiac diseases. Genetic population studies directed at...
Journal: The New England Journal of Medicine
• May 1997
Background
Left ventricular dilatation is a well-recognized precursor of ventricular dysfunction and congestive heart failure after myocardial infarction. The effect of left ventricular dilatation on...
Journal: JAMA Cardiology
• March 2018
Importance Nearly half of all patients with heart failure have preserved ejection fraction (HFpEF) as opposed to reduced ejection fraction (HFrEF), yet associations of biomarkers with future heart fa...
Journal: Nature Reviews Cardiology
• March 2015
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. Mobile technology might enable increased access to effective prevention of CVDs. Given the high penetration of sm...
Journal: Circulation
• March 2015
Background—
Guidelines have proposed that atrial fibrillation (AF) can occur as an isolated event, particularly when precipitated by a secondary, or reversible, condition. However, knowledge of long-...
Journal: Journal of the American Heart Association
• March 2013
Background
Tools for the prediction of atrial fibrillation (AF) may identify high‐risk individuals more likely to benefit from preventive interventions and serve as a benchmark to test novel putative...
Journal: The Lancet
• March 2012
Background
Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream infl...
Journal: Journal of the American College of Cardiology
• March 2011
Substantial progress has been made in the awareness, treatment, and prevention of cardiovascular disease(CVD) in women since the first women-specific clinical recommendations for the prevention of CVD w...
Journal: American Journal of Cardiology
• March 2011
Long-term risk prediction is a priority for the prevention of atrial fibrillation (AF). P wave indices are electrocardiographic measurements describing atrial conduction. The role of P wave indices in...
Journal: Circulation
• March 2009
Background— Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, induces endothelial dysfunction. Although elevated ADMA has been associated with an increased risk of...
Journal: Stroke
• March 2009
Background and Purpose— Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation of carotid atherosclerosis to cognitive...
Journal: American Journal of Epidemiology
• March 2007
For nearly 60 years, the Framingham Heart Study has examined the natural history, risk factors, and prognosis of cardiovascular, lung, and other diseases. Recruitment of the Original Cohort began in 1...
Journal: Neurology
• March 2007
Background: Systemic inflammation is associated with ischemia and Alzheimer disease (AD). We hypothesized that inflammatory biomarkers would be associated with neuroimaging markers of ischemia (i.e.,...
Journal: Circulation
• March 2007
Background— Experimental studies suggest that the natriuretic peptides influence lipid and fatty acid metabolism. Although it has been shown that obese individuals have reduced natriuretic peptide lev...
Journal: Circulation
• March 2006
Background— Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variabi...
Journal: Heart Rhythm
• March 2005
Objectives
To identify genomic regions linked to QT interval duration in an unselected population.
Background
QT interval prolongation is associated with increased risk of sudden cardiac death and...
Journal: Journal of the American College of Cardiology
• March 2005
Objectives:
The goal of this study was to assess the relations of electrocardiographic QRS duration to left ventricular (LV) measurements in individuals without heart failure (HF) or prior myocardial...
Journal: American Journal of Cardiology
• March 2004
Atrial fibrillation (AF) is a major risk factor for stroke. Although acute alcohol intake has been associated with AF, it is not known whether long-term alcohol consumption in moderation is associated...
Journal: Circulation
• March 2004
Background— Conflicting findings in the literature with regard to the ability of type A behavior, expressions of anger, or hostility to predict incident coronary heart disease (CHD) have created contr...
Journal: Hypertension
• March 2004
Aldosterone is associated with myocardial fibrosis in experimental studies and with left ventricular remodeling in heart failure patients. We hypothesized that aldosterone influences ventricular remod...
Journal: European Heart Journal
• March 2004
Aims Hyperhomocysteinaemia is a risk factor for congestive heart failure, especially in women. We investigated if homocysteine promotes left ventricular (LV) remodelling.
Methods and results We exa...
Journal: Circulation
• March 2003
Background— Experimental studies support a key role for cytokines in left ventricular remodeling. In congestive heart failure (CHF) patients, elevated plasma cytokine levels are associated with worse...
Journal: Circulation
• March 2003
Background— Mitral annular calcification (MAC) has been associated with stroke in longitudinal, community-based cohorts and cardiovascular disease (CVD) outcomes in many small retrospective studies. P...
Journal: American Journal of Cardiology
• March 1999
Little information is available on the prevalence and determinants of valvular regurgitation in the general population. This study sought to assess the prevalence and clinical determinants of mitral (...
Journal: The American Journal of the Medical Sciences
• March 1999
The prevalence, prognosis, and predictors of left ventricular hypertrophy (LVH) are reviewed, and theories of the pathogenesis of the relation between LVH and poor prognosis are summarized to highligh...
Journal: Journal of the American Medical Association
• March 1994
Objective. —To determine the independent risk factors for atrial fibrillation.
Design. —Cohort study.
Setting. —The Framingham Heart Study.
Subjects. —A total of 2090 men and 2641 women m...
Journal: Circulation Research
• June 2020
Accompanying the aging of populations worldwide, and increased survival with chronic diseases, the incidence and prevalence of atrial fibrillation (AF) are rising, justifying the term global epidemic....
Journal: Nature Genetics
• June 2018
Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to...
Journal: Circulation: Arrhythmia and Electrophysiology
• June 2018
Background:
The frequency of cardiac rhythm abnormalities and their risk factors in community-dwelling adults are not well characterized.
Methods:
We determined the frequency of rhythm abnormalitie...
Journal: American Heart Journal
• June 2013
Background
Newly diagnosed atrial fibrillation (AF) during severe sepsis is associated with increased risks of in-hospital stroke and mortality. However, the prevalence, incidence, and risk factors a...
Journal: Circulation
• June 2012
Atrial fibrillation (AF) is the most common arrhythmia and is associated with increased risks of stroke, heart failure, dementia, and death.1–8 Because the number of elderly individuals will increase...
Journal: Circulation
• June 2011
Background—
Heart failure (HF) is a clinical syndrome characterized by signs and symptoms involving multiple organ systems. Longitudinal data demonstrating that asymptomatic cardiac dysfunction prece...
Journal: Circulation
• June 2009
Background— The contributions of risk factors and disease pathogenesis to heart failure with preserved ejection fraction (HFPEF) versus heart failure with reduced ejection fraction (HFREF) have not be...
Journal: Journal of the American Medical Association
• June 2009
Context Prolongation of the electrocardiographic PR interval, known as first-degree atrioventricular block when the PR interval exceeds 200 milliseconds, is frequently encountered in clinical practice...
Journal: Circulation
• June 2009
Background— Information is limited on the longitudinal tracking of left ventricular (LV) mass over the adult life course and the determinants of such change.
Methods and Results— We used multilevel m...
Journal: Stroke
• June 2008
Background and Purpose— Previous estimates of the prevalence of silent cerebral infarction (SCI) on MRI in community-based samples have varied between 5.8% and 17.7% depending on age, ethnicity, prese...
Journal: American Journal of Cardiology
• June 2008
Exaggerated systolic blood pressure (BP) augmentation with exercise has been associated with impaired endothelial function and cardiovascular risk. However, previous studies were largely restricted to...
Journal: American Journal of Cardiology
• June 2007
Inflammatory markers, particularly C-reactive protein (CRP), predict incident cardiovascular disease and are associated with the presence of subclinical atherosclerosis. The relations between multiple...
Journal: Circulation
• June 2006
Background— Mutations in sarcomere protein, PRKAG2, LAMP2, α-galactosidase A (GLA), and several mitochondrial genes can cause rare familial cardiomyopathies, but their contribution to increased left v...
Journal: Journal of the American Medical Association
• June 2004
Context Atrial fibrillation (AF) is the most common cardiac dysrhythmia in the United States. Whereas rare cases of familial AF have been reported, it is unknown if AF among unselected individuals is...
Journal: Circulation
• June 2004
Background— Plasma levels of matrix metalloproteinase-9 (MMP-9), a key determinant of extracellular matrix degradation, are increased in heart failure and in acute coronary syndromes. We investigated...
Sleep Apnea and Markers of Vascular Endothelial Function in a Large Community Sample of Older Adults
Journal: American Journal of Respiratory and Critical Care Medicine
• June 2003
Clinical studies have suggested that sleep apnea is associated with impaired brachial artery flow-mediated dilation, a surrogate of endothelial dysfunction. We examined this question among older parti...
Journal: Annals of Internal Medicine
• June 2003
Congestive heart failure is a progressive disorder that is frequently preceded by asymptomatic left ventricular systolic dysfunction. We reviewed the epidemiology, diagnosis, and natural history of as...
Journal: Circulation
• June 2000
Our knowledge of the epidemiology of coronary heart disease (CHD) is extensive. Although CHD mortality peaked in the 1960s and then declined dramatically,1,2 CHD remains the leading cause of death in...
Journal: Hypertension
• June 1995
Abstract Increased left atrial size has been identified as a precursor of atrial fibrillation and of stroke once atrial fibrillation is manifest. Conflicting data exist regarding the effect of high bl...
Journal: The Lancet
• July 2015
Background
Comprehensive long-term data on atrial fibrillation trends in men and women are scant. We aimed to provide such data through analysis of the Framingham cohort over 50 years.
Methods
We i...
Journal: Blood
• July 2014
Platelets originate from megakaryocytes in the bone marrow and are released into the circulation as the second-most abundant blood component. Platelets are anucleated, highly granular cell fragments,...
Journal: European Heart Journal
• July 2013
Aims
Since atrial fibrillation (AF) is associated with increased risks of cardiovascular and cerebrovascular complications, estimations on the number of individuals with AF are relevant to healthcare...
Journal: Circulation: Arrhythmia and Electrophysiology
• July 2010
Background—
Obesity represents an important risk factor for atrial fibrillation (AF). We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac struct...
Journal: Circulation
• July 2010
Background— The heart progressively remodels over the life course, yet longitudinal data characterizing such remodeling in the community are limited.
Methods and Results— Using multilevel modeling, w...
Journal: Social Science & Medicine
• July 2010
Associations between life course socioeconomic position (SEP) and novel biological risk markers for coronary heart disease such as inflammatory markers are not well understood. Most studies demonstrat...
Journal: Blood
• July 2010
To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598)....
Journal: Nature Genetics
• July 2009
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,51...
Journal: Journal of the American Medical Association
• July 2009
Context Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease.
Objective To identify common genetic variants associated with...
Journal: American Journal of Cardiology
• July 2009
Basic and clinical studies have suggested that inflammation predisposes to atrial fibrillation (AF). We assessed the association of 12 circulating inflammatory biomarkers (i.e., C-reactive protein, fi...
Journal: Psychosomatic medicine
• July 2007
Objective: To determine if marriage and marital strain are related to the 10-year coronary heart disease (CHD) incidence or total
mortality. Research has demonstrated associations between marital str...
Journal: Aging Cell
• July 2006
Insulin resistance and oxidative stress are associated with accelerated telomere attrition in leukocytes. Both are also implicated in the biology of aging and in aging-related disorders, including hyp...
Journal: The New England Journal of Medicine
• July 2006
Background
The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a...
Journal: Circulation
• July 2005
Background— Arterial stiffness and mean arterial pressure variably contribute to systolic hypertension and increased cardiovascular risk. However, few prior community-based studies have evaluated the...
Journal: The New England Journal of Medicine
• July 2004
Background
Primary hyperaldosteronism is a well-recognized cause of secondary hypertension. It is unknown whether serum aldosterone levels within the physiologic range influence the risk of hypertens...
Journal: Hypertension
• July 2004
Endothelium-dependent flow-mediated dilation is a homeostatic response to short-term increases in local shear stress. Flow-mediated dilation of the brachial artery in response to postischemic reactive...
Journal: The New England Journal of Medicine
• July 1999
Background
Mitral-valve prolapse has been described as a common disease with frequent complications. To determine the prevalence of mitral-valve prolapse in the general population, as diagnosed with...
Journal: Journal of the American Medical Association
• July 1994
Objective. —To evaluate the association of echocardiographically determined left ventricular mass (LVM) with incidence of stroke or transient ischemic attack in an elderly cohort.
Design. —Cohort...
Journal: Journal of the American College of Cardiology
• January 2024
Aim
The “2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Patients With Atrial Fibrillation” provides recommendations to guide clinicians in the treatment of patients with atrial f...
Journal: Circulation
• January 2023
Background— Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bia...
Journal: Circulation
• January 2020
Background:
The American Heart Association, in conjunction with the National Institutes of Health, annually reports on the most up-to-date statistics related to heart disease, stroke, and cardiovascu...
Journal: Circulation
• January 2019
Each year, the American Heart Association (AHA), in conjunction with the National Institutes of Health and other
government agencies, brings together in a single document the most up-to-date statisti...
Journal: Tobacco Control
• January 2019
Background The role of electronic cigarettes (e-cigarettes) in product transitions has been debated.
Methods We used nationally representative data from the Population Assessment of Tobacco and Hea...
Journal: JACC: Cardiovascular Imaging
• January 2018
Objectives:
The purpose of this study was to describe the temporal trends in prevalence of left ventricular systolic dysfunction (LVSD) in individuals without and with heart failure (HF) in the commu...
Journal: Circulation
• January 2016
Background—
Atrial fibrillation (AF) and heart failure (HF) frequently coexist and together confer an adverse prognosis. The association of AF with HF subtypes has not been well described. We sought...
Journal: Nature Communications
• January 2016
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for est...
Journal: Neurology
• January 2015
Objective:
We investigated the association between circulating biomarkers of inflammation and MRI markers of small vessel disease.
Methods:
We performed a cross-sectional study relating a panel of...
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology
• January 2014
Objective—
Interleukin 1 Receptor 1 (IL1R1) and its ligand, IL1β, are upregulated in cardiovascular disease, obesity, and infection. Previously, we reported a higher level of IL1R1 transcripts in pla...
Journal: American Journal of Cardiology
• January 2014
Higher left ventricular (LV) mass, wall thickness, and internal dimension are associated with increased heart failure (HF) risk. Whether different LV hypertrophy patterns vary with respect to rates an...
Journal: Hypertension
• January 2011
Impaired vascular function contributes to the development of clinical cardiovascular disease. The relation between vasodilator function assessed noninvasively in the brachial and digital arteries rema...
Journal: Heart Rhythm
• January 2011
Background
P wave indices are an intermediate phenotype modulated by atrial conduction and electrophysiology. Their clinical correlates and association with all-cause mortality have received limited...
Journal: The Lancet
• January 2010
Background
Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up of large numbers of people. We assessed the assoc...
Journal: Circulation
• January 2010
Background— Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies have not assessed relations of a comprehensive panel of stiffnes...
Journal: Nature Genetics
• January 2010
The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of ge...
Journal: Circulation
• January 2010
Background— Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial.
Methods and Results— In 3120...
Journal: European Heart Journal
• January 2009
Aims
A recent genome-wide association study identified a haplotype block on chromosome 4q25 associated with atrial fibrillation (AF). We sought to replicate this association in four independent cohor...
Journal: Trends in Cardiovascular Medicine
• January 2009
The significance of endothelial dysfunction in cardiovascular disease is well established (Widlansky et al. 2003). In the healthy state, the endothelium produces a number of factors including nitric o...
Journal: Circulation
• January 2008
Background— Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that vitamin D deficiency ma...
Journal: Medical Clinics of North America
• January 2008
Atrial fibrillation (AF), an increasingly common dysrhythmia, is responsible for substantial morbidity and mortality. Currently in the United States, approximately 2.3 million people are diagnosed wit...
Journal: Annals of Internal Medicine
• January 2008
Background:
Studies suggest that targeting high-risk, nonhypertensive individuals for treatment may delay hypertension onset, thereby possibly mitigating vascular complications. Risk stratification m...
Journal: Chest
• January 2008
The current paradigm for the pathogenesis of COPD includes an ultimately maladaptive local inflammatory response to environmental stimuli. We examined the hypothesis that systemic inflammatory biomark...
Journal: Hypertension
• January 2007
An understanding of mechanisms underlying the development of essential hypertension is critical for designing prevention and treatment strategies. Selected biomarkers may be elevated before the onset...
Journal: American Journal of Respiratory and Critical Care Medicine
• January 2006
Rationale: Sleep-disordered breathing recurrent intermittent hypoxia and sympathetic nervous system activity surges provide the milieu for cardiac arrhythmia development.
Objective: We postulate th...
Journal: Journal of Biosocial Science
• January 2006
Lack of social integration predicts coronary heart disease mortality in prospective studies; however, the biological pathways that may be responsible are poorly understood. The specific aims of this s...
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology
• January 2003
Objective— To determine the clinical conditions associated with systemic oxidative stress in a community-based cohort. Information regarding cardiovascular risk factors associated with systemic oxidat...
Journal: Journal of the American College of Cardiology
• January 2002
Endothelial function is thought to be an important factor in the pathogenesis of atherosclerosis, hypertension and heart failure. In the 1990s, high-frequency ultrasonographic imaging of the brachial...
Journal: American Journal of Respiratory and Critical Care Medicine
• January 2001
The effect of sleep-disordered breathing (SDB) on right heart structure and function is controversial. Studies of patients referred for evaluation of possible sleep apnea have yielded conflicting resu...
Journal: The New England Journal of Medicine
• January 2001
There are 4.6 million people in the United States with heart failure today, and 550,000 new cases are being reported annually.1 Approximately 30 to 50 percent of patients with heart failure have a nor...
Journal: Journal of the American College of Cardiology
• January 1999
OBJECTIVES
The purpose of this study was to assess the relative proportions of normal versus impaired left ventricular (LV) systolic function among persons with congestive heart failure (CHF) in the...
Journal: Archives of Internal Medicine
• January 1996
The syndrome of congestive heart failure with preserved left ventricular systolic function is common in clinical practice. The signs and symptoms of the disorder are similar to those of congestive hea...
Journal: Nature
• February 2021
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of improving diagnos...
Journal: JAMA Network Open
• February 2019
Importance The use of electronic cigarettes (e-cigarettes) and other noncigarette tobacco products may increase the odds of cigarette initiation, even among low-risk youths.
Objective To evaluate...
Journal: Journal of Hepatology
• February 2017
Background & Aims
The relations of non-alcoholic fatty liver disease to cardiovascular disease (CVD) risk factors are not fully understood. The objective of our study is to explore the bi-directional...
Journal: EP Europace
• February 2017
Atrial fibrillation (AF) is an important and highly prevalent arrhythmia, which is associated with significantly increased morbidity and mortality, including a four-to five-fold increased risk for str...
Journal: Circulation
• February 2015
Background—
Cross-sectional epidemiological and clinical research suggests that lower cardiac index is associated with abnormal brain aging, including smaller brain volumes, increased white matter hy...
Journal: Journal of the American College of Cardiology
• February 2014
Objectives:
The goal of this study was to determine whether aortic pulse wave velocity (aPWV) improves prediction of cardiovascular disease (CVD) events beyond conventional risk factors.
Background:...
Journal: American Journal of Human Genetics
• February 2014
Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated w...
Journal: British Medical Journal
• February 2011
Objective To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease.
Design Mendelian randomisation meta-analysis of ind...
Journal: Circulation
• February 2011
Background—
C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated...
Journal: PLOS Genetics
• February 2011
Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C...
Journal: The American Journal of Clinical Nutrition
• February 2011
Background: There have been conflicting reported associations between dietary factors and incident atrial fibrillation (AF).
Objective: We evaluated associations between consumption of alcohol, caffe...
Journal: Nature Genetics
• February 2010
Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variants underl...
Journal: Human Molecular Genetics
• February 2010
P-selectin and intercellular adhesion molecule-1 (ICAM-1) participate in inflammatory processes by promoting adhesion of leukocytes to vascular wall endothelium. Their soluble levels have been associa...
Journal: Journal of the American Society of Nephrology
• February 2010
Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR). Whether uromodulin levels associ...
Journal: The Lancet
• February 2009
Background
Atrial fibrillation contributes to substantial increases in morbidity and mortality. We aimed to develop a risk score to predict individuals' absolute risk of developing the condition, and...
Journal: Circulation
• February 2009
The National Heart, Lung, and Blood Institute convened an expert panel April 28 to 29, 2008, to identify gaps and recommend research strategies to prevent atrial fibrillation (AF). The panel reviewed...
Journal: Nature Genetics
• February 2009
We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure–lowering properties. We genotyped SNPs at t...
Journal: Circulation
• February 2009
Background— Whereas the prevalence of coronary heart disease risk factors has declined over the past decades in the United States, acute myocardial infarction (AMI) rates have been steady. We hypothes...
Journal: Cardiology Clinics
• February 2009
Atrial fibrillation (AF), an escalating dysrhythmia, is accountable for extensive population morbidity and mortality. In the United States, approximately 2.3 million people are presently diagnosed wit...
Journal: Circulation: Arrhythmia and Electrophysiology
• February 2009
Our review describes the current field of P wave indices. We report the methodology for determining P wave indices. We also describe the strengths and limitations of the current literature on the clin...
Journal: Circulation
• February 2008
Background— Leukocyte telomere length (LTL) chronicles the cumulative burden of oxidative stress and inflammation over a life course. Activation of the renin-angiotensin-aldosterone system is associat...
Journal: Journal of the American Medical Association
• February 2007
Context Atrial fibrillation (AF) is responsible for considerable morbidity and mortality, making identification of modifiable risk factors a priority. Increased pulse pressure, a reflection of aortic...
Journal: Hypertension
• February 2007
Aldosterone:renin ratio (ARR) is used to screen for hyperaldosteronism. Data regarding correlates of ambulatory ARR in the community and its relation to hypertension incidence are limited. We defined...
Journal: Journal of the American Society of Nephrology
• February 2006
Valvular calcification is common in the setting of end-stage kidney disease and is associated with increased risks for cardiovascular disease events. It is unknown whether the prevalence of valvular c...
Journal: Circulation
• February 2005
Background— Few data have evaluated physician adherence to cardiovascular disease (CVD) prevention guidelines according to physician specialty or patient characteristics, particularly gender.
Methods...
Journal: Circulation
• February 2004
Significant advances in our knowledge about interventions to prevent cardiovascular disease (CVD) have occurred since publication of the first female-specific recommendations for preventive cardiology...
Journal: The New England Journal of Medicine
• February 2004
Background
The natriuretic peptides are counterregulatory hormones involved in volume homeostasis and cardiovascular remodeling. The prognostic significance of plasma natriuretic peptide levels in ap...
Journal: Circulation
• February 2004
Background— The mechanisms linking obesity to hypertension have not been established, but sodium retention and excessive sympathetic tone are key contributors. The natriuretic peptides are important r...
Journal: American Journal of Epidemiology
• February 1998
Stroke mortality is reported to be greater in blacks than in whites, but stroke incidence data for blacks and Hispanics are sparse. The aim of this study was to determine and compare stroke incidence...
Journal: Circulation
• February 1994
BACKGROUND
Although structural heart disease is often present in patients with nonrheumatic atrial fibrillation, the echocardiographic precursors of atrial fibrillation have not been reported previou...
Journal: Nature
• December 2022
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1,2,3,4. These substances are...
Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study
Journal: Journal of the American College of Cardiology
• December 2020
Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude o...
Journal: Journal of the American College of Cardiology
• December 2019
Atrial fibrillation (AF), a worldwide epidemic, contributes to frequent hospitalizations, stroke, heart failure, disability, mortality, and health-resource consumption (1). AF affects people different...
Journal: The Lancet
• December 2019
Background
The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We...
Journal: Journal of the American Medical Association
• December 2018
Importance Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the population. Young individuals with AF have a strong genetic association with the disease, but the mechanisms rema...
Journal: European Journal of Heart Failure
• December 2017
Aims
While heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF) are well described, determinants and outcomes of heart failure with mid-range ejection fraction (HFmrEF) remain u...
Journal: Genome Biology
• December 2016
Background
Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with...
Journal: Circulation
• December 2015
Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together t...
Journal: GeroScience
• December 2015
Cardiovascular disease and frailty frequently occur together. Both are associated with inflammation, which may be partially triggered by oxidative stress, especially in cardiovascular disease. We inve...
Journal: Circulation
• December 2013
Background—
The global burden of atrial fibrillation (AF) is unknown.
Methods and Results—
We systematically reviewed population-based studies of AF published from 1980 to 2010 from the 21 Global B...
Journal: Circulation
• December 2012
Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together t...
Journal: The Lancet
• December 2012
Background
Reliable and timely information on the leading causes of death in populations, and how these are changing, is a crucial input into health policy debates. In the Global Burden of Diseases,...
Journal: The Lancet
• December 2012
Background
Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden...
Journal: The Lancet
• December 2012
Background
Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) stu...
Journal: Journal of the American College of Cardiology
• December 2010
It is essential that the medical profession play a central role in critically evaluating the evidence related to drugs, devices, and procedures for the detection, management, or prevention of disease....
Journal: Circulation: Cardiovascular Genetics
• December 2010
Epigenetics is the study of heritable alterations in phenotypes and gene expression that occur without changes in the DNA sequence. Epigenetic mechanisms are flexible genomic factors that not only can...
Journal: The Lancet
• December 2008
Background
Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout.
Methods
Genome-wide asso...
Journal: Diabetes Care
• December 2008
OBJECTIVE
Obesity predisposes individuals to congestive heart failure (CHF) and cardiovascular disease (CVD). Leptin regulates energy homeostasis, is elevated in obesity, and influences ventricular a...
Journal: The American Journal of Medicine
• December 2007
Background
It is uncertain to what extent high C-reactive protein (CRP) concentrations reflect the presence of inflammatory conditions in the community.
Methods
We evaluated 3782 Framingham Offspri...
Journal: The New England Journal of Medicine
• December 2006
Background
Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events.
Methods
We measured...
Journal: Circulation
• December 2005
Background— Aortic stiffness and small-artery structure and function share various risk factors; however, relations between these 2 measures of vascular function are complex and incompletely understoo...
Prevalence, clinical features and prognosis of diastolic heart failure: An epidemiologic perspective
Journal: Journal of the American College of Cardiology
• December 1995
Numerous reports suggest that about one-third of patients with congestive heart failure do not have any abnormality of left ventricular systolic function. These patients presumably have heart failure...
Journal: The American Journal of Medicine
• August 2019
Background
The prevalence of e-cigarette use in the United States has increased rapidly. However, the association between e-cigarette use and cardiovascular disease remains virtually unknown. Therefo...
Journal: Annals of Internal Medicine
• August 2018
Background:
Contemporary data on the prevalence of e-cigarette use in the United States are limited.
Objective:
To report the prevalence and distribution of current e-cigarette use among U.S. adult...
Journal: Nature Reviews Cardiology
• August 2014
Atrial fibrillation (AF) is a major public health burden worldwide, and its prevalence is set to increase owing to widespread population ageing, especially in rapidly developing countries such as Braz...
Journal: Circulation
• August 2014
Background—
Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic ba...
Journal: Journal of the American Medical Association
• August 2013
Importance Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy.
Objectives To measure the burden of d...
Journal: Neurology
• August 2013
Objective:
To determine the association of arterial stiffness and pressure pulsatility, which can damage small vessels in the brain, with vascular and Alzheimer-type brain aging.
Methods:
Stroke- a...
Journal: Circulation: Cardiovascular Imaging
• August 2013
Background—
There is rapidly growing interest in applying measures of myocardial strain and synchrony in clinical investigations and in practice; data are limited regarding their reference ranges in...
Journal: Circulation
• August 2012
Background—
Biomarkers for predicting cardiovascular events in community-based populations have not consistently added information to standard risk factors. A limitation of many previously studied bi...
Journal: European Heart Journal
• August 2011
Guidelines summarize and evaluate all available evidence, at the time of the writing process, on a particular issue with the aim of assisting physicians in selecting the best management strategies for...
Journal: Circulation
• August 2010
Background— Cardiac dysfunction is associated with neuroanatomic and neuropsychological changes in aging adults with prevalent cardiovascular disease, theoretically because systemic hypoperfusion disr...
Aortic Root Remodeling Over the Adult Life Course: Longitudinal Data From the Framingham Heart Study
Journal: Circulation
• August 2010
Background— Aortic root remodeling in adulthood is known to be associated with cardiovascular outcomes. However, there is a lack of longitudinal data defining the clinical correlates of aortic root re...
Journal: Circulation
• August 2010
Background— Genetic variants on chromosome 4q25 are associated with atrial fibrillation (AF). We sought to determine whether there is more than 1 susceptibility signal at this locus.
Methods and Resu...
Journal: Nephrology Dialysis Transplantation
• August 2010
Background. Inflammation and chronic kidney disease (CKD) are both associated with cardiovascular disease (CVD). Whether inflammatory biomarkers are associated with kidney function and albuminuria aft...
Journal: Circulation
• August 2007
Background— Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear.
Methods and Results...
Journal: Circulation
• August 2007
Background— The metabolic syndrome (MetS) is associated with increased cardiovascular risk. We evaluated the relative contributions of circulating biomarkers representing distinct biological pathways...
Journal: Annals of Internal Medicine
• August 2006
Background:
Data suggest that endogenous sex hormones (testosterone, dehydroepiandrosterone sulfate [DHEA-S], and estradiol) influence cardiovascular disease (CVD) risk factors and vascular function....
Journal: Circulation
• August 2005
Background— Data are limited with regard to the relations of low-grade albuminuria (below the microalbuminuria threshold) and incidence of cardiovascular disease (CVD) events in nondiabetic, nonhypert...
Journal: Circulation
• August 2005
Background— Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory.
Methods and Resul...
Journal: Circulation
• August 2004
Background— Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated.
Methods and Results—...
Journal: Journal of the American Medical Association
• August 2003
Context Prior risk stratification schemes for atrial fibrillation (AF) have been based on randomized trial cohorts or Medicare administrative databases, have included patients with established AF, and...
Journal: The New England Journal of Medicine
• August 2002
Background
Extreme obesity is recognized to be a risk factor for heart failure. It is unclear whether overweight and lesser degrees of obesity also pose a risk.
Methods
We investigated the relation...
Journal: American Journal of Cardiology
• August 2002
Assays for natriuretic peptides have received considerable attention as potential screening tests for congestive heart failure and left ventricular dysfunction. However, information regarding the impa...
Journal: Circulation
• August 2002
Background— High C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular events, even in apparently healthy individuals. It has not been established whether elevated CR...
Journal: Circulation
• August 1995
Background The medical literature contains conflicting reports on the association of left atrial (LA) enlargement with risk of stroke. The relation of LA size to risk of stroke and death in the genera...
Journal: The New England Journal of Medicine
• August 1992
Background.
Previous clinical studies have suggested that there is an association between mitral annular calcification and the risk of stroke, but it is unclear whether this association is independen...
Journal: American Journal of Cardiology
• August 1992
Normative Doppler values and determinants of left ventricular (LV) diastolic function in healthy subjects have not been fully elucidated. Subjects from the Framingham Heart Study were examined to desc...
Journal: British Medical Journal
• April 2018
Objective To examine the association between risk factor burdens—categorized as optimal, borderline, or elevated—and the lifetime risk of atrial fibrillation.
Design Community based cohort study....
Journal: Circulation
• April 2018
Background:
Cigarette smoking has been linked with several factors associated with cardiac dysfunction. We hypothesized that cigarette smoking is associated with left ventricular (LV) structure and f...
Journal: Circulation Research
• April 2017
The past 3 decades have been characterized by an exponential growth in knowledge and advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis requires a vulnerab...
Journal: Nature Genetics
• April 2017
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death1,2. Fourteen genetic loci have been associated with atrial fibrillation in...
Journal: Nature Reviews Cardiology
• April 2016
Atrial fibrillation (AF) is the most common sustained arrhythmia in women and men worldwide. During the past century, a range of risk factors has been associated with AF, severe complications from the...
Journal: Journal of the American Heart Association
• April 2016
Background
Short‐term exposure to elevated air pollution has been associated with higher risk of acute cardiovascular diseases, with systemic oxidative stress induced by air pollution hypothesized as...
Journal: Journal of the American College of Cardiology
• April 2014
Objectives:
This study sought to identify nonredundant atrial fibrillation (AF) genetic susceptibility signals and examine their cumulative relations with AF risk.
Background:
AF-associated loci sp...
Journal: Biological Psychiatry
• April 2013
Background
Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We explo...
Journal: The Lancet
• April 2012
Background
A high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (toc...
Journal: Nature Genetics
• April 2012
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death1. We conducted a genome-wide association study (GWAS) in individuals of European ancest...
Journal: Nature Genetics
• April 2010
Consistent but indirect evidence has implicated genetic factors in smoking behavior1,2. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n =...
Journal: Heart Failure Clinics
• April 2010
Atrial fibrillation (AF) and congestive heart failure (CHF) are among the most common medical conditions and are associated with significant morbidity. These two conditions share similar risk factors,...
Journal: Circulation: Cardiovascular Genetics
• April 2010
Background—
The National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe), a planned cross-cohort analysis of genetic variation in cardiovascular, pulmonary, hematologic,...
Journal: American Journal of Epidemiology
• April 2009
Cumulative exposure to socioeconomic disadvantage across the life course may be inversely associated with coronary heart disease (CHD); the mechanisms are not fully clear. An objective of this study w...
Journal: Circulation
• April 2008
The increase in heart failure (HF) rates throughout the developed and developing regions of the world poses enormous challenges for caregivers, researchers, and policymakers. Therefore, prevention of...
Journal: Hypertension
• April 2008
Inflammation causes vascular dysfunction and perpetuates proatherosclerotic processes. We hypothesized that a broad panel of inflammatory biomarkers and single nucleotide polymorphisms in inflammatory...
Journal: Hypertension
• April 2006
Prolonged electrocardiographic QRS duration is frequently observed in congestive heart failure (CHF) patients. We hypothesized that CHF risk increases with longer QRS interval in individuals free of C...
Journal: Circulation
• April 2004
Background— Studies in selected samples have linked impaired endothelial function with cardiovascular disease and its risk factors. The clinical correlates and heritability of endothelial function in...
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