Back to Top

About

Martin G. Larson, SD, is a distinguished expert in biostatistics and public health with significant contributions to cardiovascular research. As the Co-Principal Investigator of the Framingham Heart Study, he has been instrumental in advancing the understanding of cardiovascular disease and its risk factors. Dr. Larson holds multiple academic positions at Boston University, serving as a Research Professor in the School of Public Health's Department of Biostatistics, the Department of Mathematics and Statistics, and the Chobanian & Avedisian School of Medicine. His work focuses on critical areas such as hypertension, atrial fibrillation, heart failure, and arterial stiffness. Dr. Larson's research has led to groundbreaking insights into biomarkers, including natriuretic peptides, and their role in cardiovascular health. His expertise extends to blood pressure regulation, thrombosis, and coronary artery disease, making him a leading authority in his field. Based in Framingham, Massachusetts, Dr. Larson’s work has garnered international recognition, with high rankings in public health and biostatistics. His efforts have significantly shaped the scientific understanding of cardiovascular health and disease prevention, influencing clinical practices and public health policies worldwide. Dr. Larson’s dedication to advancing cardiovascular research underscores his pivotal role in improving global health outcomes.

View More >>

Skills

Experience

Co-Principal Investigator

Framingham Heart Study (FSH)

Jan-2006 to Present

Publication

  • dott image James B Meigs
  • dott image January, 2023

Impact of Glucose Intolerance and Insulin Resistance on Cardiac Structure and Function: Sex-Related Differences in the Framingham Heart Study

Background— Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by ...

Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data fro...

Objective To examine the association between risk factor burdens—categorized as optimal, borderline, or elevated—and the lifetime risk of atrial fibrillation. Design Community based c...

Association of Cardiovascular Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction

Importance Nearly half of all patients with heart failure have preserved ejection fraction (HFpEF) as opposed to reduced ejection fraction (HFrEF), yet associations of biomarkers with futur...

  • dott image January, 2018

Epidemiology of Left Ventricular Systolic Dysfunction and Heart Failure in the Framingham Study: An Echocardiographic Study Over 3 Decades

Objectives: The purpose of this study was to describe the temporal trends in prevalence of left ventricular systolic dysfunction (LVSD) in individuals without and with heart failure (HF) in...

  • dott image November, 2017

Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation

Background: The long-term probability of developing atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden is unknown. Methods: We estimated the lifet...

  • dott image January, 2016

Atrial Fibrillation Begets Heart Failure and Vice Versa: Temporal Associations and Differences in Preserved Versus Reduced Ejection Fraction

Background— Atrial fibrillation (AF) and heart failure (HF) frequently coexist and together confer an adverse prognosis. The association of AF with HF subtypes has not been well described...

  • dott image December, 2015

Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study

Cardiovascular disease and frailty frequently occur together. Both are associated with inflammation, which may be partially triggered by oxidative stress, especially in cardiovascular diseas...

  • dott image November, 2015

Relation of Central Arterial Stiffness to Incident Heart Failure in the Community

Background Arterial stiffness, pressure pulsatility, and wave reflection are associated with cardiovascular disease. Left ventricular function is coupled to proximal aortic properties, but ...

50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study

Background Comprehensive long-term data on atrial fibrillation trends in men and women are scant. We aimed to provide such data through analysis of the Framingham cohort over 50 years. Met...

  • dott image October, 2014

B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation risk: the CHARGE-AF Consortium of community-based cohort st...

Aims B-type natriuretic peptide (BNP) and C-reactive protein (CRP) predict atrial fibrillation (AF) risk. However, their risk stratification abilities in the broad community remain uncertai...