C. Noel Bairey Merz

Director at Cedars-Sinai Medical Center
📚 Director of the Barbra Streisand Women’s Heart Center | Los Angeles, California, United States
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214 Publications
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👤 About

Skills & Expertise

Public Speaking Management Academic Writing Medical Risk Management Implementation Cardiovascular Disease Research Women's Heart Health Advocacy Clinical Cardiology Nuclear Cardiology Preventive Cardiology Rehabilitative Cardiology Stress Management Cardiac Health Exercise and Nutrition Heart Disease Prevention Precision Medicine in Cardiology Medical Research Initiatives Scientific Publishing Grant Acquisition Research Funding Health Education Medical Program Development Professional Medical Organizations Ischemic Heart Disease Diagnosis Data Safety Monitoring Clinical Trial Oversight Women's Health Program Cardiovascular Disease Prevention Strategies Media Communication Public Advocacy Clinical Research Design Translational Medicine Cardiovascular Care Gender-Specific Treatment Protocols Public Health Awareness Campaigns Advanced Cardiac Imaging Techniques National Health Initiatives Patient-Centered Care Models Evidence-Based Medicine Application

Research Interests

Cardiology Implementation Advocacy Clinical Trials Precision Medicine cardiovascular disease Preventive Medicine Exercise and Lifestyle Interventions for Health Women’s Heart Health Public Health Leadership Data Safety Monitoring Clinical Research Design Heart Disease Awareness Gender-Specific Cardiovascular Research Cardiovascular Disease Prevention in Women Nuclear Cardiology Clinical Cardiology Rehabilitative Cardiac Care Cardiovascular Event Prediction Adverse Pregnancy Outcomes Cardiovascular Disease Cholesterol Nutrition Management Heart Disease Stress Management Disease Reversal Mental Stress Ischemic Heart Disease Women Disease

Connect With Me

💼 Experience

Director

Cedars-Sinai Medical Center · January 2009 - Present

Director

Department of Cardiology Research, Cedars-Sinai · January 2013 - January 2025
  • Linda Joy Pollin Women's Heart Health Program

Director

Cedars-Sinai Medical Center · February 2018 - January 2025
  • Irwin and Sheila Allen Chair in Women's Heart Research

Professor

Department of Cardiology Research, Cedars-Sinai · January 2009 - January 2025

Professor in Residence

UCLA School of Medicine · January 2005 - January 2025

Professor

Department of Medicine, Cedars-Sinai · January 2009 - January 2025
  • Cedars-Sinai Medical Center Professional Series

Director, Clinical Scholars Program

Department of Cardiology Research, Cedars-Sinai · January 2009 - January 2025

Medical Director

Smidt Heart Institute, Cedars-Sinai Medical Center · January 2019 - January 2025
  • Irwin and Sheila Allen in Women’s Heart Research Barbra Streisand Women’s Heart Center

Medical Director and Women’s Guild Endowed Chair

Smidt Heart Institute, Cedars-Sinai Medical Center · January 2001 - January 2018
  • Barbra Streisand Women’s Heart Center

Adjunct Associate Professor of Preventive Medicine (Voluntary)

Keck School of Medicine, University of Southern California (USC) · January 1995 - January 1999

Assistant Clinical Professor of Medicine

UCLA School of Medicine · January 1990 - January 1997

Associate Cardiologist

Cedars-Sinai Medical Center · January 1988 - January 1992

Acting Director, Preventive and Rehabilitative Cardiac Center

Cedars-Sinai Medical Center · January 1990 - January 1991

Assistant Director, Cardiac Rehabilitation

Cedars-Sinai Medical Center · January 1988 - January 1990

🎓 Education

The University of Chicago (UChicago)

B.A in Biological Sciences · 2025

Cedars-Sinai Medical Center

Nuclear Cardiology in Cardiology · 1988

Cedars-Sinai Medical Center

Clinical Cardiology Fellowship in Cardiology · 1988

Cedars-Sinai Medical Center

Chief Fellow in Cardiology · 1987

American Heart Association (AHA)

Fellow in Cardiology · 1986

University of California, San Francisco (UCSF)

Chief Medical Resident in Biological Sciences · 1985

University of California, San Francisco (UCSF)

Medical Residency in Biological Sciences · 1984

Harvard Medical School (HMS)

M.D. in Biological Sciences · 1981

🚀 Projects

The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
Agency Name: National Institute on Aging || Jul 2020 - Jun 2025
Funded: Yes || Amount: $1,663,829
Project Abstract – MAE-WEST SCORE Overall Women age differently than men across the lifespan, culminating in a female predominance in morbid chronic diseases such as heart failure with preserved ejection fraction, Alzheimer’s disease and related dementias, and chronic kidney disease. Women also tend to develop multi-organ syndromes (heart-brain, heart-kidney) more frequently than men. The mechanisms underlying sex-specific differences in multi-organ dysfunction remain poorly understood. Prior work indicates that women exhibit accelerated microvascular aging, a process implicated in disorders of the heart, brain, and kidney. In this context, systemic inflammation has emerged as a primary driver of both microvascular dysfunction and the development of these chronic disease states. Preliminary data from our group indicates that eicosanoids, a diverse group of bioactive lipids that serve as the upstream mediators of systemic inflammation, can influence endothelial cell function, exhibit sexual dimorphism in circulating plasma, and are related to certain vascular phenotypes. Given these findings, we hypothesize that sexual dimorphism in both local and systemic eicosanoid variation contributes to sex differences in microvascular dysfunction and, in turn, to sex differences in age-related multi-organ disease. Motivated by our early findings and the critical need to understand the determinants and drivers of sex differences in age-related disease outcomes, we propose to create the Microvascular Aging and Eicosanoids –Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) Specialized Center of Research Excellence (SCORE) on Sex Differences. Leveraging our collective expertise, we plan to advance the understanding of sex-specific molecular drivers of chronic microvascular and end-organ disease through 3 foundational projects. In Project 1, we will examine longitudinal variation in circulating eicosanoid levels in relation to age-related alterations in microvascular function in end-organ (cardiovascular, neurocognitive, renal) disease traits in 2 large community cohorts. In Project 2, we will prospectively enroll and deeply phenotype a cohort of women and men to assess the relation of eicosanoids with organ-specific as well as global burden of microvascular disease, as well as their response to a trial of intensive medical therapy with FDA-approved agents (statins and ACEi/ARB). Finally, in Project 3, we will study the mechanistic role of sex-specific eicosanoid signaling on human endothelial cell function and on microvascular function in experimental models of organ-specific disease as well as whole organism aging. As an integral part of this SCORE, we will establish a Career Enhancement Center that will provide robust training and mentorship for trainees and junior investigators. Collectively, this highly collaborative and innovative SCORE aims to transform our understanding of sex differences in microvascular and chronic multi-organ diseases and, in turn, enable effective interventions through inter-disciplinary science, education, and advocacy. !
Noninvasive Testing of Coronary Microvascular Reactivity Using High-resolution Free-breathing MRI
Agency Name: Indiana University || Aug 2022 - Mar 2025
Sedentary Behavior and Cardiovascular Health in Young Women
Agency Name: West Virginia University Research Corp. || Sep 2022 - Present
Apr 2027
QUantifIEd Coronary Artery Plaque and OuTcomes QUIET WARRIOR Ancillary Study
Agency Name: University of Florida || Jul 2023 - Present
Jul 2026
Continuation of the NUMOM2B Heart Health Study
Agency Name: NIH/NHLBI || June 2020 - Present
Funded: Yes || Amount: $26,807
1U01 HL145358-01 A1 Principal Investigator (6% Effort) (Paker, Greenland, Saade)
Noninvasive Testing of Coronary Microvascular Reactivity Using High-resolution Freebreathing MRI
Agency Name: NIH/NHLBI || June 2020 - December 2025
Funded: Yes || Amount: $434,047
1R01 HL153430-01 Other Significant Contributor (Sharif)
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
Agency Name: NIH/NIA || June 2020 - Jan 2025
Funded: Yes || Amount: $8,414,631
1 U54 AG065141-01 Multiple PI: Bairey Merz and Cheng (20% Effort)
Effect of Intensive Medical Treatment on Quantified Coronary Artery Plaque Components with Serial Coronary CTA in Women with Non-Obstructive CAD
Agency Name: NIH/ NHLBI || June 2020 - December 2024
Funded: Yes || Amount: $263,184
1R01 HL151266-01 Co-Investigator (Tamarappoo) (5% Effort)
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)
Agency Name: NIH/NHLBI || June 2019 - December 2024
Funded: Yes || Amount: $3,309,720
5 R01 HL146158-02 Principal Investigator (20% Effort)
Inflammation and Metabolic Reprogramming of Lupus Monocytes - Mechanisms of the Pathobiology of Lupus Cardiovascular Disease
Agency Name: Department of Defense - Congressionally Directed Medical Research Program || June 2018 - June 2021
Funded: Yes || Amount: $163,301
W81XWH-18-1-0709 Co-Investigator (Jeffries) (3% Effort)
Longitudinal Evaluation of Ovarian Aging and Cardiovascular Risk
Agency Name: NIH/ NIA || June 2017 - December 2023
Funded: Yes || Amount: $11,721
5R01 AG053332-03 Principal Investigator (Cedars) (2% Effort) Role: Core Laboratory Director
Ischemia-Intensive Medical Treatment Reduces Events in Women with Nonobstructive CAD (WARRIOR)
Agency Name: : Department of Defense – Congressionally Directed Medical Research Program || June 2017 - June 2021
Funded: Yes || Amount: $14,915,728 (Sub-award: $1,765,995)
W81XWH-17-2-0030 Multiple PI: Pepine and Bairey Merz (10% Effort) Department of Defense – Congressionally Directed Medical Research Program
National PI Agreement - Microvascular Angina Study ACT14656
Agency Name: Sanofi US Services || June 2017 - June 2021
Funded: Yes || Amount: $31,610
Contract (National & Site PI) (5% Effort)
UCLA Clinical and Translational Science Institute (CTSI)
Agency Name: NIH/NCATS || June 2016 - June 2021
Funded: Yes || Amount: $1,176,021
5UL1 TR001881-05 Special Populations Co-Investigator: Multiple PI (10% Effort) PI: Dubinett, (Site Leader: Spiegel)
Heart Attack Research Program (HARP)
Agency Name: AHA/NYU Services || June 2016 - June 2025
Funded: Yes || Amount: $110,125
AHA Women’s Heart Network Co-Investigator-Site PI (Reynolds) (10% Effort)
Automated quantitative CT imaging of epicardial adipose tissue and risk of cardiac events
Agency Name: NIH/NHLBI || June 2016 - June 2020
Funded: Yes || Amount: $1,306,202
5U01 HL133616-04 Co-Investigator (Dey) (4.3% Effort)
Women’s Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction
Agency Name: Erika Glazer Family Foundation || June 2014 - June 2022
Funded: Yes || Amount: $1,200,000
Foundation Principal Investigator (1% Effort)
Accurate Perfusion MRI for Improved Diagnosis of Microvascular Coronary Disease
Agency Name: NIH/NHLBI || June 2014 - June 2021
Funded: Yes || Amount: $142,285
5R00 HL124323-05 Co-Investigator (Sharif) (1% Effort)

🎤 Conferences & Seminars (4)

Topic Related to Heart Disease in Women
Mayo Clinic · City , Alabama, Country · February 2021
No descriptions
Women and Ischemic Heart Disease
Providence Saint Joseph Medical Center · Burbank, California, Country · March 2021
No descriptions
Mental Stress and the Heart, Medical Grand Rounds
Mountain View Medical Center · Forest Grove, Oregon, Country · December 1986
No descriptions
Exercise and Coronary Artery Disease: What Should We Be Recommending to Our Patients (and Ourselves)
University of California, San Francisco (UCSF) · San Francisco, California, Country · May 1985
No descriptions

🏅 Certificates & Licenses (1)

Diplomat, American Board of Internal Medicine
Event: Diplomat, American Board of Internal Medicine · American Board of Internal Medicine · Issued on January 1984

🏆 Awards & Achievements (16)

🏆 Bernadine Healy Leadership in Women’s CV Disease Award
Awarded by: American College of Cardiology || Year: 2016
Description
🏆 Selected to moderate a National “Red Dress” Awareness Panel discussion
Awarded by: Ronald Reagan Presidential Library with First Lady Laura Bush and former First Lady Nancy Reagan || Year: 2007
Description
🏆 Awarded the Save A Heart Foundation’s 2006 Heart Saver
Awarded by: Annual Awards Gala, Los Angeles, CA || Year: 2006
Description
🏆 Alvin P. Shapiro Award
Awarded by: 2006 Annual Scientific Sessions, American Psychosomatic Society, Denver, CO || Year: 2006
Description
🏆 Women of the 21st Century Award
Awarded by: Cedars-Sinai Medical Center, Women’s Guild || Year: 2005
Description
🏆 Best Practices Awards, Special Achievement Award
Awarded by: presented to an individual who has made an outstanding contribution to the field of healthcare || Year: 2005
Description
🏆 The Red Dress Award for Leadership in Cardiovascular Research in Women
Awarded by: Woman’s Day Magazine New York || Year: 2005
Description
🏆 National Spokesperson
Awarded by: VHA Women’s Heart Advantage Program || Year: 2010
Description
🏆 Award Recipient
Awarded by: American Heart Association, Second Annual Women’s Legacy Luncheon || Year: 2002
Description
🏆 Fellow
Awarded by: American College of Cardiology (FACC) || Year: 1989
Description
🏆 Medical Education Scholarship Program Award
Awarded by: American College of Cardiology/Syntex Continuing || Year: 1987
Description
🏆 First Prize in Cardiology
Awarded by: British Medical Association (BMA) Medical Book Awards 2019 || Year: 2019
Description
🏆 Certificate of Excellence Award
Awarded by: Cedars Sinai Medical Center || Year: 2021
Description
🏆 Recognition as a Reviewer
Awarded by: Annals of Interal Medicine || Year: 2021
Description
🏆 Dudley Academic-Athletic Scholarship
Awarded by: University of Chicago || Year: 1977
Description
🏆 Young California Award
Awarded by: Governor Reagan for Heroism || Year: 1973
Description

👨‍🎓 Thesis Guided (1)

Gender and age related differences in patient with ST-elevation Myocardial Infarction
Name: Doctoral Examination Board Member || Type: Ph.D. Thesis || Status:
Institution: Radboud University, Nijmegen
Medical

Professional Memberships (19)

American Heart Association (AHA)
Member: Chair - Women in Cardiology Committee || Join dt: 2005 - 2008
Country: United States
American Heart Association (AHA)
Member: Member, Leadership of the Council on Clinical Cardiology Committee || Join dt: 2005 - 2007
Country: United States
American Heart Association (AHA)
Member: Fall Symposium Committee || Join dt: 1993 - 1994
Country: United States
American College of Cardiology (ACC)
Member: Chair - Compensation Committee || Join dt: 2007 - 2010
Country: United States
American College of Cardiology (ACC)
Member: Member, International Committee || Join dt: 2006 - 2008
Country: United States
American College of Cardiology (ACC)
Member: Chair - New Annual Meeting Strategic Development Task Force || Join dt: 2005 - Present
Country: United States
Cedars-Sinai Medical Center
Member: Altenate Member, UCLA MedCAP || Join dt: 2014 - 2020
Country: United States
Cedars-Sinai Medical Center
Member: Member, UCLA CTSI Educational Core Mentorship Task Force || Join dt: 2013 - Present
Country: United States
Cedars-Sinai Medical Center
Member: Member, Opportunity to Serve on Clinical Academic Promotions Appointment Council (CLIN-APAC) || Join dt: 2011 - 2014
Country: United States
Cedars-Sinai Medical Center
Member: Committee Member, CSMC Corday Prize Selection Process || Join dt: 2011 - Present
Country: United States
Cedars-Sinai Medical Center
Member: Member, CSMC Clinical Scholars Grant Committee || Join dt: 2009 - 2010
Country: United States
Cedars-Sinai Medical Center
Member: Member, Scientific Advisory Committee, General Clinical Research Center || Join dt: 1997 - 2010
Country: United States
Cedars-Sinai Medical Center
Member: Member, Planning Committee, Burns and Allen Research Institute Retreat || Join dt: - Present
Country: United States
Cedars-Sinai Medical Center
Member: Member, Physical Medicine and Rehabilitation Committee || Join dt: 1994 - 1996
Country: United States
Cedars-Sinai Medical Center
Member: Member, Cardiac Channel Programming Committee, Division of Cardiology || Join dt: 1993 - 1999
Cedars-Sinai Medical Center
Member: Member, Medical Staff News Committee || Join dt: 1993 - 1994
Country: United States
Cedars-Sinai Medical Center
Member: Board Member, Heart Families || Join dt: 1991 - 2000
Country: United States
Cedars-Sinai Medical Center
Member: Research Fellow Committee, Division of Cardiology || Join dt: 1991 - 1999
Country: United States
Cedars-Sinai Medical Center
Member: Member, Cardiac Advisory Board || Join dt: 1986 - 1988
Country: United States

💡 Patents (1)

Systems and methods for myocardial perfusion MRI without the need for ECG gating and additional systems and methods for improved cardiac imaging
Patent No. US10706592B2 · Filed January 2015 · Issued on July 2020
Inventors: Behzad Sharif, Debiao Li, Daniel S. Berman, C. Noel Bairey Merz || Category: Medical & Health Science
description

✉️ Invited Position (1)

Invited Panelist
Organization Name: ISfTeH - International Society for Telemedicine & eHealth || Country: United States
From 2020 - 2020

📖 Role in Research Journals (19)

Editor
Journal: Prevention Magazine || Publisher Name: Hearst Magazines
Prevention
Editorial Board Member
Journal: Archives of Internal Medicine || Publisher Name: American Medical Association (AMA)
AIM
Editor
Journal: Hypertension || Publisher Name: American Heart Association Inc
Hypertension
Editorial Advisor
Journal: European Cardiology Review || Publisher Name: Radcliffe Group Ltd
ECR
Editorial Board Member
Journal: Trials || Publisher Name: BioMed Central Ltd
Trials

📚 Publications (214)

Journal: Current Heart Failure Reports • September 2020
Purpose of the Review This review summarizes sex-related changes in the heart and vasculature that occur with aging, both in the presence and absence of cardiovascular disease (CVD). Recent Findin...
Journal: Journal of the American College of Cardiology • September 2019
Background: Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of myocardial infarction (MI) in younger women, often treated conservatively due to revascularization ris...
Journal: Journal of the American Heart Association • September 2019
Background Identifying pregnancy‐associated risk factors before the development of major cardiovascular disease events could provide opportunities for prevention. The objective of this study was to d...
Journal: Journal of the American Heart Association • September 2019
Although the number of Americans dying of cardiovascular disease (CVD) continues to increase since 2010 after decades of decrease, advances in the management of CVD have led to increased longevity amo...
Journal: European Heart Journal • September 2018
Aims  Pathologic evidence supports unique sex-specific mechanisms as precursors for acute cardiovascular (CV) events. Current evidence on long-term CV risk among women when compared with men based on...
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