C. Noel Bairey Merz

Director at Cedars-Sinai Medical Center
📚 Director of the Barbra Streisand Women’s Heart Center | Los Angeles, California, United States
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S9-012025-1008130

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214 Publications
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👤 About

Skills & Expertise

Public Speaking Management Academic Writing Medical Risk Management Implementation Cardiovascular Disease Research Women's Heart Health Advocacy Clinical Cardiology Nuclear Cardiology Preventive Cardiology Rehabilitative Cardiology Stress Management Cardiac Health Exercise and Nutrition Heart Disease Prevention Precision Medicine in Cardiology Medical Research Initiatives Scientific Publishing Grant Acquisition Research Funding Health Education Medical Program Development Professional Medical Organizations Ischemic Heart Disease Diagnosis Data Safety Monitoring Clinical Trial Oversight Women's Health Program Cardiovascular Disease Prevention Strategies Media Communication Public Advocacy Clinical Research Design Translational Medicine Cardiovascular Care Gender-Specific Treatment Protocols Public Health Awareness Campaigns Advanced Cardiac Imaging Techniques National Health Initiatives Patient-Centered Care Models Evidence-Based Medicine Application

Research Interests

Cardiology Implementation Advocacy Clinical Trials Precision Medicine cardiovascular disease Preventive Medicine Exercise and Lifestyle Interventions for Health Women’s Heart Health Public Health Leadership Data Safety Monitoring Clinical Research Design Heart Disease Awareness Gender-Specific Cardiovascular Research Cardiovascular Disease Prevention in Women Nuclear Cardiology Clinical Cardiology Rehabilitative Cardiac Care Cardiovascular Event Prediction Adverse Pregnancy Outcomes Cardiovascular Disease Cholesterol Nutrition Management Heart Disease Stress Management Disease Reversal Mental Stress Ischemic Heart Disease Women Disease

Connect With Me

💼 Experience

Director

Cedars-Sinai Medical Center · January 2009 - Present

Medical Director

Smidt Heart Institute, Cedars-Sinai Medical Center · January 2019 - January 2025
Irwin and Sheila Allen in Women’s Heart Research Barbra Streisand Women’s Heart Center

Director, Clinical Scholars Program

Department of Cardiology Research, Cedars-Sinai · January 2009 - January 2025

Professor

Department of Medicine, Cedars-Sinai · January 2009 - January 2025
Cedars-Sinai Medical Center Professional Series

Professor in Residence

UCLA School of Medicine · January 2005 - January 2025

🎓 Education

The University of Chicago (UChicago)

B.A in Biological Sciences · 2025

Cedars-Sinai Medical Center

Nuclear Cardiology in Cardiology · 1988

Cedars-Sinai Medical Center

Clinical Cardiology Fellowship in Cardiology · 1988

Cedars-Sinai Medical Center

Chief Fellow in Cardiology · 1987

American Heart Association (AHA)

Fellow in Cardiology · 1986
Description (between 50 and 1500 characters)

🚀 Projects

The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
Agency Name: National Institute on Aging || Jul 2020 - Jun 2025
Funded: Yes || Amount: $1,663,829
Project Abstract – MAE-WEST SCORE Overall Women age differently than men across the lifespan, culminating in a female predominance in morbid chronic diseases such as heart failure with preserved ejection fraction, Alzheimer’s disease and related dementias, and chronic kidney disease. Women also tend to develop multi-organ syndromes (heart-brain, heart-kidney) more frequently than men. The mechanisms underlying sex-specific differences in multi-organ dysfunction remain poorly understood. Prior work indicates that women exhibit accelerated microvascular aging, a process implicated in disorders of the heart, brain, and kidney. In this context, systemic inflammation has emerged as a primary driver of both microvascular dysfunction and the development of these chronic disease states. Preliminary data from our group indicates that eicosanoids, a diverse group of bioactive lipids that serve as the upstream mediators of systemic inflammation, can influence endothelial cell function, exhibit sexual dimorphism in circulating plasma, and are related to certain vascular phenotypes. Given these findings, we hypothesize that sexual dimorphism in both local and systemic eicosanoid variation contributes to sex differences in microvascular dysfunction and, in turn, to sex differences in age-related multi-organ disease. Motivated by our early findings and the critical need to understand the determinants and drivers of sex differences in age-related disease outcomes, we propose to create the Microvascular Aging and Eicosanoids –Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) Specialized Center of Research Excellence (SCORE) on Sex Differences. Leveraging our collective expertise, we plan to advance the understanding of sex-specific molecular drivers of chronic microvascular and end-organ disease through 3 foundational projects. In Project 1, we will examine longitudinal variation in circulating eicosanoid levels in relation to age-related alterations in microvascular function in end-organ (cardiovascular, neurocognitive, renal) disease traits in 2 large community cohorts. In Project 2, we will prospectively enroll and deeply phenotype a cohort of women and men to assess the relation of eicosanoids with organ-specific as well as global burden of microvascular disease, as well as their response to a trial of intensive medical therapy with FDA-approved agents (statins and ACEi/ARB). Finally, in Project 3, we will study the mechanistic role of sex-specific eicosanoid signaling on human endothelial cell function and on microvascular function in experimental models of organ-specific disease as well as whole organism aging. As an integral part of this SCORE, we will establish a Career Enhancement Center that will provide robust training and mentorship for trainees and junior investigators. Collectively, this highly collaborative and innovative SCORE aims to transform our understanding of sex differences in microvascular and chronic multi-organ diseases and, in turn, enable effective interventions through inter-disciplinary science, education, and advocacy. !
Noninvasive Testing of Coronary Microvascular Reactivity Using High-resolution Free-breathing MRI
Agency Name: Indiana University || Aug 2022 - Mar 2025
Sedentary Behavior and Cardiovascular Health in Young Women
Agency Name: West Virginia University Research Corp. || Sep 2022 - Present
Apr 2027
QUantifIEd Coronary Artery Plaque and OuTcomes QUIET WARRIOR Ancillary Study
Agency Name: University of Florida || Jul 2023 - Present
Jul 2026
Continuation of the NUMOM2B Heart Health Study
Agency Name: NIH/NHLBI || June 2020 - Present
Funded: Yes || Amount: $26,807
1U01 HL145358-01 A1 Principal Investigator (6% Effort) (Paker, Greenland, Saade)

🎤 Conferences & Seminars (4)

Topic Related to Heart Disease in Women
Mayo Clinic · City , State , United States · February 2021
No descriptions
Women and Ischemic Heart Disease
Providence Saint Joseph Medical Center · City , State , United States · March 2021
No descriptions
Mental Stress and the Heart, Medical Grand Rounds
Mountain View Medical Center · City , State , United States · December 1986
No descriptions
Exercise and Coronary Artery Disease: What Should We Be Recommending to Our Patients (and Ourselves)
University of California, San Francisco (UCSF) · City , State , United States · May 1985
No descriptions

🏅 Certificates & Licenses (1)

Diplomat, American Board of Internal Medicine
Event: Diplomat, American Board of Internal Medicine · American Board of Internal Medicine · Issued on January 1984

🏆 Awards & Achievements (16)

🏆 Bernadine Healy Leadership in Women’s CV Disease Award
Awarded by: American College of Cardiology || Year: 2016
🏆 Selected to moderate a National “Red Dress” Awareness Panel discussion
Awarded by: Ronald Reagan Presidential Library with First Lady Laura Bush and former First Lady Nancy Reagan || Year: 2007
🏆 Awarded the Save A Heart Foundation’s 2006 Heart Saver
Awarded by: Annual Awards Gala, Los Angeles, CA || Year: 2006
🏆 Alvin P. Shapiro Award
Awarded by: 2006 Annual Scientific Sessions, American Psychosomatic Society, Denver, CO || Year: 2006
🏆 Women of the 21st Century Award
Awarded by: Cedars-Sinai Medical Center, Women’s Guild || Year: 2005

👨‍🎓 Thesis Guided (1)

Gender and age related differences in patient with ST-elevation Myocardial Infarction
Name: Doctoral Examination Board Member || Type: Ph.D. Thesis
Institution: Radboud University, Nijmegen
Medical

Professional Memberships (19)

American Heart Association (AHA)
Member: Chair - Women in Cardiology Committee || Join dt: 2005 - 2008
Country: United States
American Heart Association (AHA)
Member: Member, Leadership of the Council on Clinical Cardiology Committee || Join dt: 2005 - 2007
Country: United States
American Heart Association (AHA)
Member: Fall Symposium Committee || Join dt: 1993 - 1994
Country: United States
American College of Cardiology (ACC)
Member: Chair - Compensation Committee || Join dt: 2007 - 2010
Country: United States
American College of Cardiology (ACC)
Member: Member, International Committee || Join dt: 2006 - 2008
Country: United States

💡 Patents (1)

Systems and methods for myocardial perfusion MRI without the need for ECG gating and additional systems and methods for improved cardiac imaging
Patent No. US10706592B2 · Filed January 2015 · Issued on July 2020
Inventors: Behzad Sharif, Debiao Li, Daniel S. Berman, C. Noel Bairey Merz || Category: Medical & Health Science
description

✉️ Invited Position (1)

Invited Panelist
Organization Name: ISfTeH - International Society for Telemedicine & eHealth || Country: United States
From 2020 - 2020

📖 Role in Research Journals (18)

Editorial Board Member
Journal: Archives of Internal Medicine || Publisher Name: American Medical Association (AMA)
AIM
Editor
Journal: Hypertension || Publisher Name: American Heart Association Inc
Hypertension
Editorial Advisor
Journal: European Cardiology Review || Publisher Name: Radcliffe Group Ltd
ECR
Editorial Board Member
Journal: Trials || Publisher Name: BioMed Central Ltd
Trials
Editor
Journal: American Journal of Managed Care || Publisher Name: Clinical Care Targeted Communications Group, LLC
AJMC

📚 Publications (214)

Journal: Current Heart Failure Reports • September 2020
Purpose of the Review This review summarizes sex-related changes in the heart and vasculature that occur with aging, both in the presence and absence of cardiovascular disease (CVD). Recent Findin...
Journal: Journal of the American Heart Association • September 2019
Although the number of Americans dying of cardiovascular disease (CVD) continues to increase since 2010 after decades of decrease, advances in the management of CVD have led to increased longevity amo...
Journal: Journal of the American Heart Association • September 2019
Background Identifying pregnancy‐associated risk factors before the development of major cardiovascular disease events could provide opportunities for prevention. The objective of this study was to d...
Journal: Journal of the American College of Cardiology • September 2019
Background: Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of myocardial infarction (MI) in younger women, often treated conservatively due to revascularization ris...
Journal: European Heart Journal • September 2018
Aims  Pathologic evidence supports unique sex-specific mechanisms as precursors for acute cardiovascular (CV) events. Current evidence on long-term CV risk among women when compared with men based on...
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