C. Noel Bairey Merz
About
Director, Barbra Streisand Women's Heart Center
Director, Linda Joy Pollin Women's Heart Health Program
Director, Preventive and Rehabilitative Cardiac Center, Smidt Heart
Institute
Professor, Cardiology
Cedars-Sinai Medical Center
C. Noel Bairey Merz, MD, is Director of the Barbra Streisand Women’s Heart Center, the Linda Joy Pollin Women’s Heart Health Program, the Erika J. Glazer Women’s Heart Research Initiative, and the Preventive Cardiac Center at the Smidt Cedars-Sinai Heart Institute. She also is Professor of Medicine at Cedars-Sinai Medical Center.
Dr. Bairey Merz’s research interests include women and cardiovascular disease, mental stress and heart disease, the role of exercise and stress management in reversing disease, the role of cholesterol and nutrition management in heart disease, adverse pregnancy outcomes and cardiovascular disease, and precision medicine monitoring to predict unexpected cardiovascular events. She is chair of the National Heart, Lung and Blood Institute (NHLBI)-sponsored WISE (Women’s Ischemic Syndrome Evaluation) initiative, which is investigating potential methods for more effective diagnosis and evaluation of ischemic heart disease in women. Dr. Bairey Merz has received investigational grants from the National Heart, Lung and Blood Institute (NHLBI), NIH-National Center for Alternative and Complementary Medicine (NCCAM), the National Institutes of Aging (NIA), the Flight Attendants Medical Research Institute, the Pfeiffer Foundation, the Eli and Edythe Broad Foundation, the Barbra Streisand Foundation, the Erika J. Glazer Women’s Heart Research Initiative, the Society for Women’s Health Research, the Linda Joy Pollin Women’s Heart Health Program, and the Congressionally Directed Medical Research Program of the Department of Defense.
A prolific lecturer, Dr. Bairey Merz, is a member of many professional organizations, including the American Heart Association, the American College of Cardiology (ACC), the European Society of Cardiology, the American Association of Physicians, the Association of University Cardiologists, the Advisory Board of the NIH Office of Research in Women’s Health, and chairs of the ACC CVD in Women Committee. She is past member of the NHLBI Advisory Council, the Board of Trustees of the ACC, and is a past-chair of the Prevention of Cardiovascular Disease committee, and the Women in Cardiology Committee of the AHA. Other professional associations have included membership on the National Space Biomedical Research Institute Board of Scientific Counselors, the American Board of Internal Medicine (ABIM) Board of Examiners, and she chaired the NIH-sponsored Bypass Angioplasty Revascularization Investigations 2 Diabetes (BARI-2D) Data Safety Monitoring Board (DSMB). She serves on the advisory boards of lay organizations, including WomenHeart, and the Women’s Heart Alliance. She has an extensive scientific publication record of over 450 scientific publications and book chapters, and more than 300 abstracts. Her work has been published in numerous peer-reviewed journals including the New England Journal of Medicine, the Journal of the American Medical Association, Circulation, the Journal of the American College of Cardiology, and the Journal of Women’s Health.
Dr. Bairey Merz has received numerous awards and honors including the ACC Bernadine Healy Leadership in Women’s CV Disease Award, 2016, the 2014 Professional Achievement Award from the University of Chicago, the 2013 Fellowship Award from the International Academy of Cardiovascular Sciences in Winnipeg, Manitoba, Canada, the 2012 17th Annual Women in Leadership Award from the City of West Hollywood, CA, the 2012 Distinguished Scientist (Clinical Domain) Award from the American College of Cardiology, the 2012 Journal of Women’s Health Award for Outstanding Achievement in Women’s Health Research award, the 2011-2012 Annual DeSteven’s Lectureship from Northwestern University in Chicago IL, the 2011 Visiting Professorship, Christiana Care Health System award, the 2009 AHA Women in Cardiology Mentoring Award, the 2008 McCue Female Cardiologist of the Year Award, the 2005 Red Dress Award For Leadership in Cardiovascular Research in Women, the 2005 VHA Inc. Best Practices Awards for Special Achievement Award presented to an individual who has made an outstanding contribution to the field of health care, the 2005 Women of the 21st Century award from the Women’s Guild of Cedars-Sinai Medical Center, and the 2006 Alvin P. Shapiro Award by Psychosomatic Society for excellence in clinical research. Dr. Bairey Merz has appeared frequently in the media, recognized as an authority on the subject of heart disease. Her television appearances have included 60 Minutes, the Today Show, Dr. Oz, Good Morning America, NBC Dateline and 20/20. She has also been interviewed for articles published in The New York Times, Ladies Home Journal, US News & World Report and Working Woman Magazine, to name a few.
Dr. Bairey Merz received her bachelor’s degree from the University of Chicago and her medical degree from Harvard University. She completed her residency at the University of California, San Francisco, where she served as Chief Medical Resident. Dr. Bairey Merz also completed fellowships in clinical cardiology and nuclear cardiology and served as Chief Cardiology Fellow at Cedars-Sinai Medical Center.
Dr. C. Noel Bairey Merz holds the Women's Guild Endowed Chair in Women's Health, and is director of the Women's Heart Center as well as the Preventive and Rehabilitative Cardiac Center at Cedars-Sinai Medical Center. She also is professor of medicine at Cedars-Sinai Medical Center in Los Angeles.
Dr. Bairey Merz's research interests include women and heart disease, mental stress and heart disease, the role of exercise and stress management in reversing disease, and the role of nutrition in heart disease. Currently, she is chair of the National Institutes of Health (NIH)-sponsored WISE (Women's Ischemic Syndrome Evaluation) initiative, which is investigating potential methods for more effective diagnosis and evaluation of coronary artery disease in women. Dr. Bairey Merz has received investigational grants from the NIH-National Heart, Lung and Blood Institute (NHLBI), NIH-National Center for Alternative and Complementary Medicine (NCCAM), the Pfeiffer Foundation, the Eli and Edythe Broad Foundation, the Barbra Streisand Foundation and the Women's Guild.
A prolific lecturer, Dr. Bairey Merz is a member of many professional organizations, including the American Heart Association (AHA), the American College of Cardiology (ACC), the NHLBI Advisory Council, the Academy of Behavioral Medicine Research, the American Society of Preventive Cardiology, the Association of Academic Women's Health Programs, and the Association of Women's Heart Programs. She serves on the Board of Trustees of the ACC, where she is a fellow, and is a past-chair of the Prevention of Cardiovascular Disease committee. She currently holds the chair of the Women in Cardiology Committee of the AHA. Other professional associations include membership on the National Space Biomedical Research Institute Board of Scientific Counselors, the American Board of Internal Medicine (ABIM) Board of Examiners, and she is chair of the NIH-sponsored Bypass Angioplasty Revascularization Investigations 2 Diabetes (BARI-2D) Data Safety Monitoring Board (DSMB). She serves on the advisory boards of lay organizations, including Women's Heart and Sister-to-Sister.
Dr. Bairey Merz has an extensive scientific publication record consisting of over 180 scientific publications, more than 200 abstracts, and numerous book chapters. Her work has been published in numerous peer-reviewed journals including the New England Journal of Medicine, the Journal of the American Medical Association, Circulation, the Journal of the American College of Cardiology, and the Journal of Women's Health.
Dr. Bairey Merz has received numerous awards and honors including: the 2008 McCue Female Cardiologist of the Year Award; the 2005 Red Dress Award for Leadership in Cardiovascular Research in Women; the 2005 VHA Inc. Best Practices Awards for Special Achievement Award, presented to an individual who has made an outstanding contribution to the field of healthcare; the 2005 Women of the 21st Century award from the Women's Guild of Cedars-Sinai Medical Center, and the 2006 Alvin P. Shapiro Award from the Psychosomatic Society, for excellence in clinical research.
Dr. Bairey Merz has appeared frequently in the media, recognized as an authority on the subject of heart disease and stress. Her television appearances have included Good Morning America, NBC Dateline and 20/20. She has also been interviewed for articles published in the New York Times, Ladies Home Journal, USNews & World Report and Working Woman Magazine, to name a few. Dr. Bairey Merz is currently the national spokesperson for VHA's Women's HeartAdvantage campaign, which seeks to raise awareness of heart disease in women.
Dr. Bairey Merz received her bachelor's degree from the University of Chicago and her medical degree from Harvard University. She completed her residency at the University of California, San Francisco, where she served as Chief Medical Resident. Dr. Bairey Merz also completed fellowships in clinical cardiology and nuclear cardiology at Cedars-Sinai Medical Center.
Skills & Expertise
Public Speaking
Management
Academic Writing
Medical
Risk Management
Implementation
Cardiovascular Disease Research
Women's Heart Health Advocacy
Clinical Cardiology
Nuclear Cardiology
Preventive Cardiology
Rehabilitative Cardiology
Stress Management
Cardiac Health
Exercise and Nutrition
Heart Disease Prevention
Precision Medicine in Cardiology
Medical Research Initiatives
Scientific Publishing
Grant Acquisition
Research Funding
Health Education
Medical Program Development
Professional Medical Organizations
Ischemic Heart Disease Diagnosis
Data Safety Monitoring
Clinical Trial Oversight
Women's Health Program
Cardiovascular Disease Prevention Strategies
Media Communication
Public Advocacy
Clinical Research Design
Translational Medicine
Cardiovascular Care
Gender-Specific Treatment Protocols
Public Health Awareness Campaigns
Advanced Cardiac Imaging Techniques
National Health Initiatives
Patient-Centered Care Models
Evidence-Based Medicine Application
Research Interests
Cardiology
Implementation
Advocacy
Clinical Trials
Precision Medicine
cardiovascular disease
Preventive Medicine
Exercise and Lifestyle Interventions for Health
Women’s Heart Health
Public Health Leadership
Data Safety Monitoring
Clinical Research Design
Heart Disease Awareness
Gender-Specific Cardiovascular Research
Cardiovascular Disease Prevention in Women
Nuclear Cardiology
Clinical Cardiology
Rehabilitative Cardiac Care
Cardiovascular Event Prediction
Adverse Pregnancy Outcomes
Cardiovascular Disease
Cholesterol
Nutrition Management
Heart Disease
Stress Management
Disease Reversal
Mental Stress
Ischemic Heart Disease
Women Disease
Connect With Me
Experience
Director
Director
- Linda Joy Pollin Women's Heart Health Program
Director
- Irwin and Sheila Allen Chair in Women's Heart Research
Professor
Professor in Residence
Professor
- Cedars-Sinai Medical Center Professional Series
Director, Clinical Scholars Program
Medical Director
- Irwin and Sheila Allen in Women’s Heart Research Barbra Streisand Women’s Heart Center
Medical Director and Women’s Guild Endowed Chair
- Barbra Streisand Women’s Heart Center
Adjunct Associate Professor of Preventive Medicine (Voluntary)
Assistant Clinical Professor of Medicine
Associate Cardiologist
Acting Director, Preventive and Rehabilitative Cardiac Center
Assistant Director, Cardiac Rehabilitation
Education
The University of Chicago (UChicago)
Cedars-Sinai Medical Center
Cedars-Sinai Medical Center
Cedars-Sinai Medical Center
American Heart Association (AHA)
University of California, San Francisco (UCSF)
University of California, San Francisco (UCSF)
Harvard Medical School (HMS)
Projects
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
Project Abstract – MAE-WEST SCORE Overall Women age differently than men across the lifespan, culminating in a female predominance in morbid chronic diseases such as heart failure with preserved ejection fraction, Alzheimer’s disease and related dementias, and chronic kidney disease. Women also tend to develop multi-organ syndromes (heart-brain, heart-kidney) more frequently than men. The mechanisms underlying sex-specific differences in multi-organ dysfunction remain poorly understood. Prior work indicates that women exhibit accelerated microvascular aging, a process implicated in disorders of the heart, brain, and kidney. In this context, systemic inflammation has emerged as a primary driver of both microvascular dysfunction and the development of these chronic disease states. Preliminary data from our group indicates that eicosanoids, a diverse group of bioactive lipids that serve as the upstream mediators of systemic inflammation, can influence endothelial cell function, exhibit sexual dimorphism in circulating plasma, and are related to certain vascular phenotypes. Given these findings, we hypothesize that sexual dimorphism in both local and systemic eicosanoid variation contributes to sex differences in microvascular dysfunction and, in turn, to sex differences in age-related multi-organ disease. Motivated by our early findings and the critical need to understand the determinants and drivers of sex differences in age-related disease outcomes, we propose to create the Microvascular Aging and Eicosanoids –Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) Specialized Center of Research Excellence (SCORE) on Sex Differences. Leveraging our collective expertise, we plan to advance the understanding of sex-specific molecular drivers of chronic microvascular and end-organ disease through 3 foundational projects. In Project 1, we will examine longitudinal variation in circulating eicosanoid levels in relation to age-related alterations in microvascular function in end-organ (cardiovascular, neurocognitive, renal) disease traits in 2 large community cohorts. In Project 2, we will prospectively enroll and deeply phenotype a cohort of women and men to assess the relation of eicosanoids with organ-specific as well as global burden of microvascular disease, as well as their response to a trial of intensive medical therapy with FDA-approved agents (statins and ACEi/ARB). Finally, in Project 3, we will study the mechanistic role of sex-specific eicosanoid signaling on human endothelial cell function and on microvascular function in experimental models of organ-specific disease as well as whole organism aging. As an integral part of this SCORE, we will establish a Career Enhancement Center that will provide robust training and mentorship for trainees and junior investigators. Collectively, this highly collaborative and innovative SCORE aims to transform our understanding of sex differences in microvascular and chronic multi-organ diseases and, in turn, enable effective interventions through inter-disciplinary science, education, and advocacy. !
Noninvasive Testing of Coronary Microvascular Reactivity Using High-resolution Free-breathing MRI
Sedentary Behavior and Cardiovascular Health in Young Women
Apr 2027
QUantifIEd Coronary Artery Plaque and OuTcomes QUIET WARRIOR Ancillary Study
Jul 2026
Continuation of the NUMOM2B Heart Health Study
1U01 HL145358-01 A1 Principal Investigator (6% Effort)
(Paker, Greenland, Saade)
Noninvasive Testing of Coronary Microvascular Reactivity Using High-resolution Freebreathing MRI
1R01 HL153430-01 Other Significant Contributor (Sharif)
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)
1 U54 AG065141-01 Multiple PI: Bairey Merz and Cheng (20% Effort)
Effect of Intensive Medical Treatment on Quantified Coronary Artery Plaque Components with Serial Coronary CTA in Women with Non-Obstructive CAD
1R01 HL151266-01 Co-Investigator (Tamarappoo) (5% Effort)
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)
5 R01 HL146158-02 Principal Investigator (20% Effort)
Inflammation and Metabolic Reprogramming of Lupus Monocytes - Mechanisms of the Pathobiology of Lupus Cardiovascular Disease
W81XWH-18-1-0709 Co-Investigator (Jeffries) (3% Effort)
Longitudinal Evaluation of Ovarian Aging and Cardiovascular Risk
5R01 AG053332-03 Principal Investigator (Cedars) (2% Effort)
Role: Core Laboratory Director
Ischemia-Intensive Medical Treatment Reduces Events in Women with Nonobstructive CAD (WARRIOR)
W81XWH-17-2-0030 Multiple PI: Pepine and Bairey Merz (10% Effort)
Department of Defense – Congressionally Directed Medical Research Program
National PI Agreement - Microvascular Angina Study ACT14656
Contract (National & Site PI) (5% Effort)
UCLA Clinical and Translational Science Institute (CTSI)
5UL1 TR001881-05 Special Populations Co-Investigator: Multiple PI (10% Effort)
PI: Dubinett, (Site Leader: Spiegel)
Heart Attack Research Program (HARP)
AHA Women’s Heart Network Co-Investigator-Site PI (Reynolds) (10% Effort)
Automated quantitative CT imaging of epicardial adipose tissue and risk of cardiac events
5U01 HL133616-04 Co-Investigator (Dey) (4.3% Effort)
Women’s Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction
Foundation Principal Investigator (1% Effort)
Accurate Perfusion MRI for Improved Diagnosis of Microvascular Coronary Disease
5R00 HL124323-05 Co-Investigator (Sharif) (1% Effort)
Conferences & Seminars (4)
Topic Related to Heart Disease in Women
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Women and Ischemic Heart Disease
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Mental Stress and the Heart, Medical Grand Rounds
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Exercise and Coronary Artery Disease: What Should We Be Recommending to Our Patients (and Ourselves)
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Certificates & Licenses (1)
Diplomat, American Board of Internal Medicine
Awards & Achievements (16)
🏆 Bernadine Healy Leadership in Women’s CV Disease Award
Description
🏆 Selected to moderate a National “Red Dress” Awareness Panel discussion
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🏆 Awarded the Save A Heart Foundation’s 2006 Heart Saver
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🏆 Alvin P. Shapiro Award
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🏆 Women of the 21st Century Award
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🏆 Best Practices Awards, Special Achievement Award
Description
🏆 The Red Dress Award for Leadership in Cardiovascular Research in Women
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🏆 National Spokesperson
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🏆 Award Recipient
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🏆 Fellow
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🏆 Medical Education Scholarship Program Award
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🏆 First Prize in Cardiology
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🏆 Certificate of Excellence Award
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🏆 Recognition as a Reviewer
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🏆 Dudley Academic-Athletic Scholarship
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🏆 Young California Award
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Thesis Guided (1)
Gender and age related differences in patient with ST-elevation Myocardial Infarction
Institution: Radboud University, Nijmegen
Professional Memberships (19)
American Heart Association (AHA)
Country: United States
American Heart Association (AHA)
Country: United States
American Heart Association (AHA)
Country: United States
American College of Cardiology (ACC)
Country: United States
American College of Cardiology (ACC)
Country: United States
American College of Cardiology (ACC)
Country: United States
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Country: United States
Cedars-Sinai Medical Center
Country: United States
Patents (1)
Systems and methods for myocardial perfusion MRI without the need for ECG gating and additional systems and methods for improved cardiac imaging
description
Invited Position (1)
Invited Panelist
Role in Research Journals (19)
Editor
Prevention
Editorial Board Member
AIM
Editor
Hypertension
Editorial Advisor
ECR
Editorial Board Member
Trials
Publications (214)
Purpose of the Review
This review summarizes sex-related changes in the heart and vasculature that occur with aging, both in the presence and absence of cardiovascular disease (CVD).
Recent Findin...
Background:
Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of myocardial infarction (MI) in younger women, often treated conservatively due to revascularization ris...
Background
Identifying pregnancy‐associated risk factors before the development of major cardiovascular disease events could provide opportunities for prevention. The objective of this study was to d...
Although the number of Americans dying of cardiovascular disease (CVD) continues to increase since 2010 after decades of decrease, advances in the management of CVD have led to increased longevity amo...
Aims
Pathologic evidence supports unique sex-specific mechanisms as precursors for acute cardiovascular (CV) events. Current evidence on long-term CV risk among women when compared with men based on...
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