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About

JoAnn E. Manson, MD, DrPH, MACP, is Professor of Medicine and the Michael and Lee Bell Professor of Women’s Health at Harvard Medical School, Professor in the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Chief of the Division of Preventive Medicine at Brigham and Women's Hospital (BWH), and Scientific Advisor to the BWH Connors Center for Women’s Health and Sex/Gender Medicine. Dr. Manson is a physician epidemiologist, endocrinologist, and Principal Investigator (PI) or co-PI of several research studies, including the Women’s Health Initiative Clinical Center In Boston, the cardiovascular component of the Nurses’ Health Study, the VITamin D and OmegA-3 TriaL (VITAL); the COcoa Supplement and Multivitamin Outcomes Study (COSMOS), and the VItamin D for COVID-19 (VIVID) trial. Her primary research interests include randomized clinical prevention trials of nutritional and lifestyle factors related to heart disease, diabetes, and cancer, the role of endogenous and exogenous estrogens as determinants of chronic disease, life course-related risk factors for CVD in women, and biomarker predictors of CVD. Dr. Manson has received numerous honors, including the American Heart Association’s (AHA) Population Research Prize, the AHA’s Distinguished Scientist Award, the AHA’s Research Achievement Award, election to the Institute of Medicine of the National Academies (National Academy of Medicine), membership in the Association of American Physicians (AAP), fellowship in AAAS, the Woman in Science Award from the American Medical Women’s Association, the Bernadine Healy Award for Visionary Leadership in Women’s Health, the Massachusetts Medical Society awards in both Public Health and Women’s Health Research, the James D. Bruce Memorial Award for Distinguished Contributions in Preventive Medicine from the American College of Physicians (ACP), and election to mastership in ACP. Dr. Manson has published more than 1,200 peer-reviewed articles in the medical literature, is the author or editor of several books and textbooks, serves as Editor-in-Chief of Contemporary Clinical Trials, and is a past president of the North American Menopause Society. She is one of the most highly cited researchers in the world and was one of the physicians featured in the National Library of Medicine’s exhibition, History of American Women Physicians. She received her BA from Harvard College, her MD from Case Western Reserve University School of Medicine, and an MPH and DrPH from the Harvard School of Public Health. Dr. JoAnn Manson has been a leading researcher in the two largest women's health research projects ever launched in the United States—the first large scale study of women begun in 1976 as the Harvard Nurses' Health Study, and the National Institute of Health's Women's Health Initiative, which involved 164,000 healthy women. Until the early 1990s, research on human health was usually done from all-male subject groups, and the results generated were thought to apply to both sexes. Federal regulation now mandates the inclusion of women in all research studies, as men and women may react differently to certain diseases and drug remedies, a fact Dr. Manson's research efforts have helped to establish. JoAnn Elisabeth Manson was in 1953, in Cleveland, Ohio. She comes from a strong scientific background; her mother was a medical social worker and her father worked as an engineer for the National Aeronautics and Space Administration. Her high-school chemistry teacher encouraged her to train in the sciences, yet her school friends knew her artistic side best, particularly her painting, sculpture, and musical talents playing the harp. She was able to develop all her interests at Harvard University, reviewing dance and theater for the Harvard Independent while studying pre-med. Her well-rounded approach to life and to work has earned her the respect of colleagues and patients alike. Dr. Manson is best known to the public for her sensible advice on healthy living, which stems from her research on women and heart disease. With co-author Patricia Amend, she published The 30-Minute Fitness Solution: A Four-Step Plan for Women of All Ages, which explains her key idea of the preventative health benefits of gentle exercise. She has long been advising her patients to take up small lifestyle changes for long term health benefits, recognizing that no-cost activities like brisk walking can be a simple way of improving the health of women of all backgrounds and fitness levels. She often uses her prescription pad to write up an exercise regime for a patient instead of a course of pills. Patients applaud her "bedside manner." Her medical practice serves 400 patients, yet she takes time to tailor her care to fit in with individual schedules and interests. Such attention to the individual, not simply the medical problem, has been honored by Boston Magazine who listed her as one of their "Top Docs for Women" in 2001 Dr. Manson's colleagues also credit her ability to deal with "difficult personalities" and competitive environments. Such qualities serve her well at work—in 1999 she was appointed full professor at Harvard Medical School, where women hold only 9 percent of faculty professorships. Not withstanding her own professional achievements, Dr. Manson is still well aware of the gender disparities in academic medicine. As she commented in The Houston Chronicle, "[w]omen are still confronting barriers to their success. The glass ceiling may have some cracks in it, but it hasn't yet come crashing down." Dr. Manson is playing her own part in making a change by participating in mentoring programs and giving young practitioners extensive guidance and support. She is extremely proud of the students she has helped, and lists their professional achievements in her C.V. In 1997, along with Oprah Winfrey and former First Lady Betty Ford, she was honored by American Health for Women magazine at a ceremony for their "Ten Heroes in Women's Health." Ladies Home Journal named her one of their top ten "Champions of Women's Health" in 2000. As well as her numerous roles as researcher, physician, teacher, and writer, Dr. Manson is a mother. She and her husband, Christopher Ames, try to balance work and family life with their two children.

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Skills

Experience

Chief, Division of Preventive Medicine

Brigham and Women's Hospital (BWH)

Mar-1999 to Present
Professor

Harvard Medical School (HMS)

Jan-2008 to Jan-2025

Education

Publication

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Background It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. Methods We conducted a n...

Association analysis identifies 65 new breast cancer risk loci

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to bre...

Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents

Background Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant data meta-analyses of pr...

Cardiovascular Disease in Women: Clinical Perspectives

Cardiovascular disease continues to be the leading cause of death among women in the United States, accounting for ≈1 of every 3 female deaths. Sex-specific data focused on cardiovascular ...

Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized ...

Importance Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention. Objective To report a comprehensive...

Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association

Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings ...

The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know

This article summarizes the new 2011 report on dietary requirements for calcium and vitamin D from the Institute of Medicine (IOM). An IOM Committee charged with determining the population n...

Triggering of Sudden Death from Cardiac Causes by Vigorous Exertion

Background Retrospective and cross-sectional data suggest that vigorous exertion can trigger cardiac arrest or sudden death and that habitual exercise may diminish this risk. However, the r...

Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause

Context The timing of initiation of hormone therapy may influence its effect on cardiovascular disease. Objective To explore whether the effects of hormone therapy on risk of cardiovascul...

Calcium/Vitamin D Supplementation and Cardiovascular Events

Background— Individuals with vascular or valvular calcification are at increased risk for coronary events, but the relationship between calcium consumption and cardiovascular events is unc...

Projects

Jun-2015 to Jun-2020

Effects of Vitamin D and Fish Oil on the Kidney in Hypertensives

To test whether vitamin D3 (at a dose of 2,000 IU/day) or omega-3 fatty acids (eicosapentaenoic acid plus docosahexaenoic acid, 1 gm/day) will preserve kidney function, as measured by serum creatinine and cystatin C, over a 4 year period.
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Jun-2010 to Jun-2020

Randomized Trial of Vitamin D and Omega-3 Fatty Acids for Diabetic Kidney Disease

To examine the prevention of development and progression of diabetic kidney disease in a randomized, placebo-controlled clinical trial of vitamin D3 and omega-3 fatty acids.
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Jun-2010 to Jun-2020

VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-TriaL

To investigate the effects of long-term supplementation (5 years) with two agents – vitamin D3 (2000 IU/d) and marine omega-3 fatty acids (1000 mg/d) – on reducing the risk of late-life depression and yielding better mood scores over time in a 2x2 randomized, double-blind, placebo-controlled factorial trial among 20,000 men and women, aged ≥60 and ≥65 years, respectively.
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Jun-2009 to Jun-2020

Interrelationship of Magnesium, Vitamin D, and Cardiometabolic Outcomes in the VITAL Trial

Supplemental funding to the Parent VITAL trial will examine the interrelationship of magnesium, vitamin D, and cardiometabolic outcomes in the VITAL trial.
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Jun-2009 to Jun-2020

The VITamin D and OmegA-3 TriaL (VITAL) Renewal

The goal of this study is to conduct a large, cost-effective, randomized, double-blind, placebo-controlled, 2x2 factorial trial of vitamin D (in the form of D3 [Cholecalciferol]) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA} = docosahexaenoic acid [DHA]) supplements in the primary prevention of cancer and cardiovascular disease (CVD).
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Jun-2014 to Jun-2019

Randomized Trial of Cocoa Flavanols and Multivitamins for CVD and CA Prevention (COSMOS Blood)

Ancillary study to the COSMOS trial will add supplemental blood and urine tests to the COSMOS parent trial.
Jun-2014 to Jun-2019

Randomized Trial of Cocoa Flavanols and Multivitamins for CVD and CA Prevention (COSMOS)

To conduct a randomized, double-blind, placebo-controlled, 2x2 factorial trial of a patented, high-quality cocoa extract and a multivitamin supplement (Centrum Silver) in the prevention of cardiovascular disease (CVD) and cancer in 18,000 women and men aged >60 years with 4 years of treatment and follow-up.
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Jun-2008 to Jun-2019

Risk Factors for Ischemic Stroke, Renewal

To evaluate the associations of individual metabolite and metabolomic profiles with subsequent ischemic stroke among women in the Nurses’ Health Study I and Nurses’ Health Study II, ongoing longitudinal prospective cohort studies.
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Jun-1984 to Jun-2018

Risk Factors for CVD in Women

To examine promising but as-yet-unproven biochemical predictors of coronary heart disease (CHD) in a prospective cohort of women in the Nurses’ Health Study, currently aged 60-85 years.
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Jun-2015 to Dec-2020

Dietary and Hormonal Determinants of Cancer in Women (Project 2)

To study modifiable determinants of breast, colorectal, and ovarian cancers using metabolomic signatures in the etiology and progression of these cancers.
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Honours & Awards

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Best Female Scientist Award
Awarded by:

Research.com

Year: 2024
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Best Scientist Award
Awarded by:

Research.com

Year: 2024
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Medicine in United States Leader Award
Awarded by:

Research.com

Year: 2024
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Best Female Scientist Award
Awarded by:

Research.com

Year: 2023
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Distinguished Scientist Award
Awarded by:

American Heart Association

Year: 2011
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Distinguished Scientist Award
Awarded by:

American Heart Association

Year: 2011
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History of American Women Physicians
Awarded by:

Bethesda, Maryland

Year: 2011
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top 1% most cited scientists in the world
Awarded by:

Thomson Reuters

Year: 2011
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Population Research Prize
Awarded by:

American Heart Association

Year: 2010
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Fellow
Awarded by:

the Royal Society of Edinburgh

Year: 2009
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Henry Burger Research Prize
Awarded by:

International Menopause Society

Year: 2008
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Postmenopausal Cardiovascular Health Research Award
Awarded by:

North American Menopause Society

Year: 2007
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Women's Professional Achievement Award
Awarded by:

Harvard College

Year: 2006
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election to membership
Awarded by:

Association of American Physicians

Year: 2005
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"Women in Science" Award
Awarded by:

American Medical Women's Association

Year: 2003
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Henry Ingersoll Bowditch Award for Excellence in Public Health
Awarded by:

Massachusetts Medical Society

Year: 2002
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Outstanding Contribution Award & quot
Awarded by:

WHI

Year: 1995
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Alpha Omega Alpha Honor Medical Society
Awarded by:

Alpha Honor Medical Society

Year: 1978