JoAnn E. Manson

Chief, Division of Preventive Medicine at Brigham and Women's Hospital (BWH)
📚 Professor of Medicine, Michael and Lee Bell Professor of Women’s Health, Harvard Medical School | Boston, Massachusetts, United States
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80 Publications
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👤 About

Skills & Expertise

Clinical Trials Endocrinology Medicine Epidemiology Preventive Medicine Women's Health Sculpture Physicians Research Leadership Randomized Clinical Trials Nutritional and Lifestyle Research Biomarker Analysis Chronic Disease Prevention Cardiovascular Disease Research Diabetes Research Cancer Research Hormonal Research Model Risk Assessment Scientific Writing and Editing Academic Mentorship Public Health Advocacy Healthy Lifestyle Promotion Patient-Centered Care Teaching and Mentoring Gender Equity Advocacy in Medicine

Research Interests

Diabetes Endocrinology Public Health Epidemiology Principal Investigator physician endocrinologist Health Study Women's health cancer cardiovascular disease Cardiovascular Trial Genetic Risk CVD Vitamin D Omega-3 Trial COSMOS trial Women's Health Cardiovascular Disease Prevention Preventive Medicine Nutritional and Lifestyle Factors in Chronic Disease Biomarker Predictors of Chronic Disease Hormonal Influences on Chronic Diseases Clinical Trials and Research Methodology Mentorship in Academic Medicine Gender Disparities in Healthcare Exercise and Lifestyle Interventions for Health Health Policy and Advocacy for Women Editing in Medical Research

Connect With Me

💼 Experience

Chief, Division of Preventive Medicine

Brigham and Women's Hospital (BWH) · March 1999 - Present

Professor

Harvard Medical School (HMS) · January 2008 - January 2025
  • Medicine

Professor

Harvard T.H. Chan School of Public Health, Boston · January 1999 - January 2025
  • Dept of Epidemiology

🎓 Education

Harvard T.H. Chan School of Public Health, Boston

DrPH in Medicine · 1987

Harvard T.H. Chan School of Public Health, Boston

MPH in Medicine · 1984

School of Medicine, Case Western Reserve University

MD in Medicine · 1979

Radcliffe Institute for Advanced Study

AB in Medicine · 1975

🚀 Projects

Risk Factors for CVD in Women
Agency Name: NIH / NHLBI (Bethesda, US) || June 1984 - June 2018
To examine promising but as-yet-unproven biochemical predictors of coronary heart disease (CHD) in a prospective cohort of women in the Nurses’ Health Study, currently aged 60-85 years.
Risk Factors for Ischemic Stroke, Renewal
Agency Name: NIH / NHLBI (Bethesda, US) || June 2008 - June 2019
To evaluate the associations of individual metabolite and metabolomic profiles with subsequent ischemic stroke among women in the Nurses’ Health Study I and Nurses’ Health Study II, ongoing longitudinal prospective cohort studies.
The VITamin D and OmegA-3 TriaL (VITAL) Renewal
Agency Name: NIH / NCI (Bethesda, US) || June 2009 - June 2020
The goal of this study is to conduct a large, cost-effective, randomized, double-blind, placebo-controlled, 2x2 factorial trial of vitamin D (in the form of D3 [Cholecalciferol]) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA} = docosahexaenoic acid [DHA]) supplements in the primary prevention of cancer and cardiovascular disease (CVD).
Interrelationship of Magnesium, Vitamin D, and Cardiometabolic Outcomes in the VITAL Trial
Agency Name: NIH / NCI (Bethesda, US) || June 2009 - June 2020
Supplemental funding to the Parent VITAL trial will examine the interrelationship of magnesium, vitamin D, and cardiometabolic outcomes in the VITAL trial.
VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-TriaL
Agency Name: NIH / NIMH (Bethesda, US) || June 2010 - June 2020
To investigate the effects of long-term supplementation (5 years) with two agents – vitamin D3 (2000 IU/d) and marine omega-3 fatty acids (1000 mg/d) – on reducing the risk of late-life depression and yielding better mood scores over time in a 2x2 randomized, double-blind, placebo-controlled factorial trial among 20,000 men and women, aged ≥60 and ≥65 years, respectively.
Randomized Trial of Vitamin D and Omega-3 Fatty Acids for Diabetic Kidney Disease
Agency Name: NIH / NIDDK (Bethesda, US) || June 2010 - June 2020
To examine the prevention of development and progression of diabetic kidney disease in a randomized, placebo-controlled clinical trial of vitamin D3 and omega-3 fatty acids.
Randomized Trial of Cocoa Flavanols and Multivitamins for CVD and CA Prevention (COSMOS)
Agency Name: Mars, Symbioscience (Gaithersburg, US) || June 2014 - June 2019
To conduct a randomized, double-blind, placebo-controlled, 2x2 factorial trial of a patented, high-quality cocoa extract and a multivitamin supplement (Centrum Silver) in the prevention of cardiovascular disease (CVD) and cancer in 18,000 women and men aged >60 years with 4 years of treatment and follow-up.
Randomized Trial of Cocoa Flavanols and Multivitamins for CVD and CA Prevention (COSMOS Blood)
Agency Name: Mars, Symbioscience (Gaithersburg, US) || June 2014 - June 2019
Ancillary study to the COSMOS trial will add supplemental blood and urine tests to the COSMOS parent trial.
Effects of Vitamin D and Fish Oil on the Kidney in Hypertensives
Agency Name: NIH / NIDDK (Bethesda, US) || June 2015 - June 2020
To test whether vitamin D3 (at a dose of 2,000 IU/day) or omega-3 fatty acids (eicosapentaenoic acid plus docosahexaenoic acid, 1 gm/day) will preserve kidney function, as measured by serum creatinine and cystatin C, over a 4 year period.
Dietary and Hormonal Determinants of Cancer in Women (Project 2)
Agency Name: National Cancer Institute, NIH || June 2015 - December 2020
To study modifiable determinants of breast, colorectal, and ovarian cancers using metabolomic signatures in the etiology and progression of these cancers.

🏆 Awards & Achievements (18)

🏆 top 1% most cited scientists in the world
Awarded by: Thomson Reuters || Year: 2011
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🏆 History of American Women Physicians
Awarded by: Bethesda, Maryland || Year: 2011
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🏆 Distinguished Scientist Award
Awarded by: American Heart Association || Year: 2011
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🏆 Population Research Prize
Awarded by: American Heart Association || Year: 2010
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🏆 Henry Burger Research Prize
Awarded by: International Menopause Society || Year: 2008
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🏆 Postmenopausal Cardiovascular Health Research Award
Awarded by: North American Menopause Society || Year: 2007
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🏆 Women's Professional Achievement Award
Awarded by: Harvard College || Year: 2006
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🏆 election to membership
Awarded by: Association of American Physicians || Year: 2005
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🏆 "Women in Science" Award
Awarded by: American Medical Women's Association || Year: 2003
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🏆 Henry Ingersoll Bowditch Award for Excellence in Public Health
Awarded by: Massachusetts Medical Society || Year: 2002
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🏆 Outstanding Contribution Award & quot
Awarded by: WHI || Year: 1995
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🏆 Alpha Omega Alpha Honor Medical Society
Awarded by: Alpha Honor Medical Society || Year: 1978
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🏆 Fellow
Awarded by: the Royal Society of Edinburgh || Year: 2009
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🏆 Distinguished Scientist Award
Awarded by: American Heart Association || Year: 2011
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🏆 Best Female Scientist Award
Awarded by: Research.com || Year: 2023
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🏆 Medicine in United States Leader Award
Awarded by: Research.com || Year: 2024
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🏆 Best Scientist Award
Awarded by: Research.com || Year: 2024
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🏆 Best Female Scientist Award
Awarded by: Research.com || Year: 2024
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📚 Publications (80)

Journal: Journal of Applied Physiology • September 2005
Epidemiological studies suggest that physically active individuals have a 30–50% lower risk of developing type 2 diabetes than do sedentary persons and that physical activity confers a similar risk re...
Journal: Journal of the American Medical Association • September 2004
Context Physical activity may help maintain cognitive function in older adults. Objective To examine the relation of long-term regular physical activity, including walking, to cognitive function....
Journal: The New England Journal of Medicine • September 2002
Background The role of walking, as compared with vigorous exercise, in the prevention of cardiovascular disease remains controversial. Data for women who are members of minority racial or ethnic grou...
Journal: The New England Journal of Medicine • September 2001
Background Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown. Methods We followed...
Journal: The American Journal of Clinical Nutrition • September 1999
Background Although current dietary guidelines for Americans recommend increased intake of grain products to prevent coronary heart disease (CHD), epidemiologic data relating whole-grain intake to th...
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