JoAnn E. Manson
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About
JoAnn E. Manson, MD, DrPH, MACP, is Professor of Medicine and the Michael and Lee Bell Professor of Women’s Health at Harvard Medical School, Professor in the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Chief of the Division of Preventive Medicine at Brigham and Women's Hospital (BWH), and Scientific Advisor to the BWH Connors Center for Women’s Health and Sex/Gender Medicine.
Dr. Manson is a physician epidemiologist, endocrinologist, and Principal Investigator (PI) or co-PI of several research studies, including the Women’s Health Initiative Clinical Center In Boston, the cardiovascular component of the Nurses’ Health Study, the VITamin D and OmegA-3 TriaL (VITAL); the COcoa Supplement and Multivitamin Outcomes Study (COSMOS), and the VItamin D for COVID-19 (VIVID) trial. Her primary research interests include randomized clinical prevention trials of nutritional and lifestyle factors related to heart disease, diabetes, and cancer, the role of endogenous and exogenous estrogens as determinants of chronic disease, life course-related risk factors for CVD in women, and biomarker predictors of CVD.
Dr. Manson has received numerous honors, including the American Heart Association’s (AHA) Population Research Prize, the AHA’s Distinguished Scientist Award, the AHA’s Research Achievement Award, election to the Institute of Medicine of the National Academies (National Academy of Medicine), membership in the Association of American Physicians (AAP), fellowship in AAAS, the Woman in Science Award from the American Medical Women’s Association, the Bernadine Healy Award for Visionary Leadership in Women’s Health, the Massachusetts Medical Society awards in both Public Health and Women’s Health Research, the James D. Bruce Memorial Award for Distinguished Contributions in Preventive Medicine from the American College of Physicians (ACP), and election to mastership in ACP.
Dr. Manson has published more than 1,200 peer-reviewed articles in the medical literature, is the author or editor of several books and textbooks, serves as Editor-in-Chief of Contemporary Clinical Trials, and is a past president of the North American Menopause Society. She is one of the most highly cited researchers in the world and was one of the physicians featured in the National Library of Medicine’s exhibition, History of American Women Physicians. She received her BA from Harvard College, her MD from Case Western Reserve University School of Medicine, and an MPH and DrPH from the Harvard School of Public Health.
Dr. JoAnn Manson has been a leading researcher in the two largest women's health research projects ever launched in the United States—the first large scale study of women begun in 1976 as the Harvard Nurses' Health Study, and the National Institute of Health's Women's Health Initiative, which involved 164,000 healthy women. Until the early 1990s, research on human health was usually done from all-male subject groups, and the results generated were thought to apply to both sexes. Federal regulation now mandates the inclusion of women in all research studies, as men and women may react differently to certain diseases and drug remedies, a fact Dr. Manson's research efforts have helped to establish.
JoAnn Elisabeth Manson was in 1953, in Cleveland, Ohio. She comes from a strong scientific background; her mother was a medical social worker and her father worked as an engineer for the National Aeronautics and Space Administration. Her high-school chemistry teacher encouraged her to train in the sciences, yet her school friends knew her artistic side best, particularly her painting, sculpture, and musical talents playing the harp.
She was able to develop all her interests at Harvard University, reviewing dance and theater for the Harvard Independent while studying pre-med. Her well-rounded approach to life and to work has earned her the respect of colleagues and patients alike.
Dr. Manson is best known to the public for her sensible advice on healthy living, which stems from her research on women and heart disease. With co-author Patricia Amend, she published The 30-Minute Fitness Solution: A Four-Step Plan for Women of All Ages, which explains her key idea of the preventative health benefits of gentle exercise. She has long been advising her patients to take up small lifestyle changes for long term health benefits, recognizing that no-cost activities like brisk walking can be a simple way of improving the health of women of all backgrounds and fitness levels. She often uses her prescription pad to write up an exercise regime for a patient instead of a course of pills.
Patients applaud her "bedside manner." Her medical practice serves 400 patients, yet she takes time to tailor her care to fit in with individual schedules and interests. Such attention to the individual, not simply the medical problem, has been honored by Boston Magazine who listed her as one of their "Top Docs for Women" in 2001
Dr. Manson's colleagues also credit her ability to deal with "difficult personalities" and competitive environments. Such qualities serve her well at work—in 1999 she was appointed full professor at Harvard Medical School, where women hold only 9 percent of faculty professorships.
Not withstanding her own professional achievements, Dr. Manson is still well aware of the gender disparities in academic medicine. As she commented in The Houston Chronicle, "[w]omen are still confronting barriers to their success. The glass ceiling may have some cracks in it, but it hasn't yet come crashing down." Dr. Manson is playing her own part in making a change by participating in mentoring programs and giving young practitioners extensive guidance and support. She is extremely proud of the students she has helped, and lists their professional achievements in her C.V.
In 1997, along with Oprah Winfrey and former First Lady Betty Ford, she was honored by American Health for Women magazine at a ceremony for their "Ten Heroes in Women's Health." Ladies Home Journal named her one of their top ten "Champions of Women's Health" in 2000.
As well as her numerous roles as researcher, physician, teacher, and writer, Dr. Manson is a mother. She and her husband, Christopher Ames, try to balance work and family life with their two children.
Skills & Expertise
Clinical Trials
Endocrinology
Medicine
Epidemiology
Preventive Medicine
Women's Health
Sculpture
Physicians
Research Leadership
Randomized Clinical Trials
Nutritional and Lifestyle Research
Biomarker Analysis
Chronic Disease Prevention
Cardiovascular Disease Research
Diabetes Research
Cancer Research
Hormonal Research
Model Risk Assessment
Scientific Writing and Editing
Academic Mentorship
Public Health Advocacy
Healthy Lifestyle Promotion
Patient-Centered Care
Teaching and Mentoring
Gender Equity Advocacy in Medicine
Research Interests
Diabetes
Endocrinology
Public Health
Epidemiology
Principal Investigator
physician
endocrinologist
Health Study
Women's health
cancer
cardiovascular disease
Cardiovascular Trial
Genetic Risk
CVD
Vitamin D
Omega-3 Trial
COSMOS trial
Women's Health
Cardiovascular Disease Prevention
Preventive Medicine
Nutritional and Lifestyle Factors in Chronic Disease
Biomarker Predictors of Chronic Disease
Hormonal Influences on Chronic Diseases
Clinical Trials and Research Methodology
Mentorship in Academic Medicine
Gender Disparities in Healthcare
Exercise and Lifestyle Interventions for Health
Health Policy and Advocacy for Women
Editing in Medical Research
Connect With Me
Experience
Chief, Division of Preventive Medicine
Professor
- Medicine
Professor
- Dept of Epidemiology
Education
Harvard T.H. Chan School of Public Health, Boston
Harvard T.H. Chan School of Public Health, Boston
School of Medicine, Case Western Reserve University
Radcliffe Institute for Advanced Study
Projects
Risk Factors for CVD in Women
To examine promising but as-yet-unproven biochemical predictors of coronary heart disease (CHD) in a prospective cohort of women in the Nurses’ Health Study, currently aged 60-85 years.
Risk Factors for Ischemic Stroke, Renewal
To evaluate the associations of individual metabolite and metabolomic profiles with subsequent ischemic stroke among women in the Nurses’ Health Study I and Nurses’ Health Study II, ongoing longitudinal prospective cohort studies.
The VITamin D and OmegA-3 TriaL (VITAL) Renewal
The goal of this study is to conduct a large, cost-effective, randomized, double-blind, placebo-controlled, 2x2 factorial trial of vitamin D (in the form of D3 [Cholecalciferol]) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA} = docosahexaenoic acid [DHA]) supplements in the primary prevention of cancer and cardiovascular disease (CVD).
Interrelationship of Magnesium, Vitamin D, and Cardiometabolic Outcomes in the VITAL Trial
Supplemental funding to the Parent VITAL trial will examine the interrelationship of magnesium, vitamin D, and cardiometabolic outcomes in the VITAL trial.
VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-TriaL
To investigate the effects of long-term supplementation (5 years) with two agents – vitamin D3 (2000 IU/d) and marine omega-3 fatty acids (1000 mg/d) – on reducing the risk of late-life depression and yielding better mood scores over time in a 2x2 randomized, double-blind, placebo-controlled factorial trial among 20,000 men and women, aged ≥60 and ≥65 years, respectively.
Randomized Trial of Vitamin D and Omega-3 Fatty Acids for Diabetic Kidney Disease
To examine the prevention of development and progression of diabetic kidney disease in a randomized, placebo-controlled clinical trial of vitamin D3 and omega-3 fatty acids.
Randomized Trial of Cocoa Flavanols and Multivitamins for CVD and CA Prevention (COSMOS)
To conduct a randomized, double-blind, placebo-controlled, 2x2 factorial trial of a patented, high-quality cocoa extract and a multivitamin supplement (Centrum Silver) in the prevention of cardiovascular disease (CVD) and cancer in 18,000 women and men aged >60 years with 4 years of treatment and follow-up.
Randomized Trial of Cocoa Flavanols and Multivitamins for CVD and CA Prevention (COSMOS Blood)
Ancillary study to the COSMOS trial will add supplemental blood and urine tests to the COSMOS parent trial.
Effects of Vitamin D and Fish Oil on the Kidney in Hypertensives
To test whether vitamin D3 (at a dose of 2,000 IU/day) or omega-3 fatty acids (eicosapentaenoic acid plus docosahexaenoic acid, 1 gm/day) will preserve kidney function, as measured by serum creatinine and cystatin C, over a 4 year period.
Dietary and Hormonal Determinants of Cancer in Women (Project 2)
To study modifiable determinants of breast, colorectal, and ovarian cancers using metabolomic signatures in the etiology and progression of these cancers.
Awards & Achievements (18)
🏆 top 1% most cited scientists in the world
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🏆 History of American Women Physicians
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🏆 Distinguished Scientist Award
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🏆 Population Research Prize
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🏆 Henry Burger Research Prize
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🏆 Postmenopausal Cardiovascular Health Research Award
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🏆 Women's Professional Achievement Award
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🏆 election to membership
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🏆 "Women in Science" Award
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🏆 Henry Ingersoll Bowditch Award for Excellence in Public Health
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🏆 Outstanding Contribution Award & quot
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🏆 Alpha Omega Alpha Honor Medical Society
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🏆 Fellow
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🏆 Distinguished Scientist Award
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🏆 Best Female Scientist Award
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🏆 Medicine in United States Leader Award
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🏆 Best Scientist Award
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🏆 Best Female Scientist Award
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Publications (80)
Epidemiological studies suggest that physically active individuals have a 30–50% lower risk of developing type 2 diabetes than do sedentary persons and that physical activity confers a similar risk re...
Context Physical activity may help maintain cognitive function in older adults.
Objective To examine the relation of long-term regular physical activity, including walking, to cognitive function....
Background
The role of walking, as compared with vigorous exercise, in the prevention of cardiovascular disease remains controversial. Data for women who are members of minority racial or ethnic grou...
Background
Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown.
Methods
We followed...
Background
Although current dietary guidelines for Americans recommend increased intake of grain products to prevent coronary heart disease (CHD), epidemiologic data relating whole-grain intake to th...
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