Azetidine ring, salicylic acid, and salicylic acid bioisosteres as determinants of the binding characteristics of novel potent compounds to Stat3
Abstract
Statsignal transducer and activator of transcriptionPBSTphosphate-buffered saline tween-20PBSphosphate-buffered salineEMSAelectrophoretic mobility shift assayEGFRepidermal growth factor receptor, JAK, Janus kinase, SH2, Src homology 2, MAPK, mitogen-activated protein kinaseErkextracellular signal-regulated kinaseFBSfetal bovine serum
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