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About

Dr. Holubkov has over 25 years of experience as an applied biostatistician, focusing on the design, execution and analysis of prospective interventional studies, with a focus on pediatrics and cardiology. Dr. Holubkov received his Ph.D. in Biostatistics from the University of Washington in 1995, and was a faculty member at the University of Pittsburgh prior to joining the University of Utah in 2002. At the University of Pittsburgh, Dr. Holubkov was chief biostatistician for the NHLBI Registries of Percutaneous Coronary Interventions and the two NHLBI Bypass Angioplasty Revascularization Investigations (BARI), and he also directed the Coordinating Center for an industry-sponsored international randomized trial comparing two mechanical heart valves. At the University of Utah, he is the Co-Principal Investigator and Chief Biostatistician for the NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN) Coordinating Center since the network'e (CPCCRN) inception, Director of the Coordinating Center for the NHLBI-funded Hydrocephalus Research Network (HCRN), Co-Director of the Study Design and Biostatistics Center in the Center for Clinical Sciences (CCTS), and the chief biostatistician for the NHLBI’s Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) trials. Dr. Holubkov also regularly teaches courses on the design and analysis of randomized clinical trials and mentors clinical investigators as well as students in the Masters of Statistics Program. Dr. Holubkov has authored or co-authored more than 100 publications in the areas of pediatrics, cardiology and statistical methodology. He serves on several Data Safety Monitoring Boards and protocol review committees. Dr. Holubkov has over 25 years of experience as an applied biostatistician, focusing on the design, execution, and analysis of prospective interventional studies, with a focus on pediatrics and interventional surgery. Dr. Holubkov received his Ph.D. in Biostatistics from the University of Washington in 1995, and was a faculty member at the University of Pittsburgh prior to joining the University of Utah in 2002. Dr. Holubkov directs activities of the Data Coordinating Center for the Adult Hydrocephalus Research Network (AHCRN).

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Skills

Experience

Professor of Pediatrics

University of Utah, Salt Lake

Jan-2010 to Present

Publication

Mild Renal Insufficiency Is Associated With Angiographic Coronary Artery Disease in Women

Background— Mild renal insufficiency is associated with an increased risk for cardiovascular events in women with coronary artery disease (CAD). However, the relationship between mild rena...

APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study

Genetic variation in the apolipoprotein E (APOE) gene is a significant determinant of variation in plasma cholesterol levels and it also affects the risk of coronary artery disease (CAD). We...

Genetic Variation in Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 (LOX1) Gene and the Risk of Coronary Artery Disease

Background— We examined the association of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronary artery disease in the Women’s Ischemia Syndrome Ev...

  • dott image January, 2003

Association between the Severity of Angiographic Coronary Artery Disease and Paraoxonase Gene Polymorphisms in the National Heart, Lung, and Blood Ins...

Paraoxonase (PON), a high-density lipoprotein–associated enzyme, is believed to protect against low-density lipoprotein oxidation and thus affects the risk of coronary artery disease (CAD)...

Large brachial artery diameter is associated with angiographic coronary artery disease in women

Background: Noninvasive methods are needed for the identification of women at highest risk for coronary artery disease (CAD) who might benefit most from aggressive preventive therapy. Identi...

Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: Results from the NHLBI WISE...

Background Chest pain in the absence of obstructive coronary artery disease (CAD) is common in women; it is frequently associated with debilitating symptoms and repeated evaluations and may ...

Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women’s Ischemia Syndrome Eval...

The purpose of this study is to provide a contemporary qualitative and quantitative analysis of coronary angiograms from a large series of women enrolled in the Women’s Ischemia Syndrome E...

Dobutamine stress echocardiography in women with chest pain: Pilot phase data from the National Heart, Lung and Blood Institute Women’s Ischemia Syn...

OBJECTIVES The aim of this project was to assess the utility of dobutamine stress echocardiography (DSE) for evaluation of women with suspected ischemic heart disease. BACKGROUND Most...