Eric H. Rosenn

Research Volunteer at Mount Sinai Health System
📚 Research Volunteer at Mount Sinai Health System | Brookline, Massachusetts, United States
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5 Publications
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👤 About

Skills & Expertise

Computational Biology Data Analysis Biochemistry Molecular Biology Public Speaking Leadership Medical Procedures Phlebotomy EKG EMT-B BLS Lab Safety Training IACUC Hazmat/HazWaste Training OSHA Compliance C-14 Certification Research Writing Scientific Communication Academic Editing EHR Management Military Leadership Crisis Management Public Health Event Coordination Python

Research Interests

Biochemistry Molecular Biology Bioinformatics Scientific Writing Public Health Neurobiology Medical Technology Computational Biology Evolutionary Biology Systems Biology Medical Research Human Cognition Leadership and Diplomacy Military Medicine Data Science in Healthcare

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💼 Experience

Research Volunteer

Mount Sinai Health System · August 2023 - Present
  • Internship

Research Internship

NYU Langone Health · June 2022 - August 2022

Physician Assistant/ Medical Scribe

Pediatric Associates of Plainview (PAOP) · May 2018 - May 2020
  • Oversaw patient check-in, taking height and weight and administering TOVA diagnostic computer tests Worked with insurance companies and diagnostic labs to set up an Electronic Health Records (EHR) system Prepped exam rooms in between visits and maintained equipment Took notes on doctors' and patients’ comments during regular visits for addition to patients' chart

Volunteer

New York Cares · May 2019 - April 2020

Microbiology Research Internship

Binghamton Biofilm Research Center (BBRC) · May 2015 - May 2016
  • Explored biofilm formation and its impact, with contributions to "Mycobacterium smegmatis: Vaccinomics Insights and Applications".

Sergeant and Medic, Paratroopers Brigade

Israel Defense Forces (IDF) · May 2013 - May 2015
  • Responsible for leading platoon of 36 soldiers in combat during Operation Brother’s Keeper and Operation Protective Edge. Received specialized training and served as Medic while stationed at operations centers Decorated twice by Company XO and Battalion Commander, received citations from the Nassau County Legislature and New York State Assembly

🎓 Education

Boston University (BU)

M.E. in Biomedical/Medical Engineering · Pursuing

Tel Aviv University (TAU)

Preclinical Studies in Medicine · 2023

The City College of New York (CCNY)

M.SC in Biochemistry · 2019

Binghamton University (BU)

B.Sc. in Biochemistry · 2018

🎤 Conferences & Seminars (3)

Artificial Intelligence and Nutrigenomics in Clinical Care Can Affect Large Scale Population Health; A Review
Sackler School of Medicine Research Symposium · New York, New York, Country · April 2023
Conference: Tel Aviv University Sackler Research Symposium :10.13140/RG.2.2.22903.91046
Computer Learning Can Streamline Development of Delivery Constructs Increasing the Bioavailability of Nutraceutical Compounds
Cold Spring Harbor Laboratory · New York, New York, Country · May 2023
Lipid nanoparticle (LNP) formulations may allow for more precise targeted therapeutic use of bioactive dietary metabolites such as phenolic compounds [1]. The protective construct allows pure nutrient formulations to overcome effects of first pass metabolism and access sites across the blood brain barrier; yielding precise effects [2]. Nutrients and bioactive metabolites resulting from gut digestion are thus brought into focus as potential candidates in the development of targeted therapies as well as interesting lead compounds for treatment of neurodegenerative diseases like Alzheimer's [3]. A system of Machine learning for predicting LNP formulations was developed by Wang et al. and displayed the ability to optimize mRNA carriers and delivery [4]. Inherent to this system is a process of computer-simulated in vitro pharmacodynamic and cross-reactivity testing that could be more widely applied to many delivery systems [5]. The ability to predict optimal delivery constructs, as well as simulate a compounds interactome, could lead to the discovery of novel clinical applications for nutrient compounds and revolutionize the therapeutic development pipeline [6]. In this review we synthesize key current literature involving the optimization of lipid nano particle encapsulated nutraceutical compounds using machine learning methods. We further strive to assess the limitations of such systems and the predictive capabilities of computer simulated in vitro models. Finally, we discuss how such therapies might fit into the landscape of nutrition and preventive medicine. Nutrients and the Gut-Brain Axis: Novel Neurotherapeutic Applications •The gut microbiota has a unique reciprocal interaction with the brain, a series of interactions referred to as the gut-brain axis. •The microbiome acts as a positive modulator on the brain by digesting compounds normal human cells don't and producing secondary bioactive metabolites such as polyphenols that can cross the blood-brain barrier and have antioxidant properties, extending a neuroprotective effects against brain aging and neurodegenerative disorders (Figure 1) [7]. • In exploring the clinical application of these compounds, however, it was found that even concentrated formulations of the active metabolites, administered orally, failed to reach significant levels in the in the brain majorly due to problems crossing the blood-brain barrier [8]. •Trapani et al. [9] discuss a solution to this in the development of polyphenol-lipid nanoparticles. These were delivered sublingually or intranasal and due to their small lipophilic nature are easily able to be absorbed across the oral or nasal mucosa and effectively bypass the blood brain barrier by accessing the olfactory or trigeminal nerves.
Lipid Nanoparticle Encapsulated Bioactive Gut Metabolites: Potential Therapeutics for Treating Neurodegenerative Disorders
Cold Spring Harbor Laboratory · New York, New York, Country · June 2024
In this review we synthesize key current literature involving the optimization of lipid nanoparticle encapsulated bioactive metabolite compounds for formulation of targeted therapeutics and their potential in treating neurologic disorders, specifically neurodegenerative diseases such as Alzheimer’s. Presented at Cold Spring Harbor Laboratory 88th Symposium on Quantitative Biology: Brain Body Physiology

🏅 Certificates & Licenses (5)

BLS, EMT-B certifications
VEEBs EMS Academy Long Island · Issued on May 2018
EHOS lab safety trainings: IACUC training, Hazmat/ HazWaste Training, OSHA training
City College of New York · Issued on May 2019
Leadership and Diplomacy in Global Times
Israeli Ministry of Foreign Affairs · Issued on May 2023
Phlebotomy Technician Certification (PTC)
The Manhattan Institute · Issued on May 2018
BLS
NYS · Issued on May 2018

🏆 Awards & Achievements (2)

🏆 Citation
Awarded by: Nassau County Legislature || Year: 2015
Description
🏆 Citation
Awarded by: New York State Assembly || Year: 2015
Description

📚 Publications (5)

Journal: Vaccines • July 2023
Mycobacterium smegmatis (M.sm) is frequently used as an alternative model organism in Mycobacterium tuberculosis (M.tb) studies. While containing high sequence homology with M.tb, it is considered non...
M.sm Vaccine vector Omics System biology Infectious diseases Vaccinomics Tuberculosis
Journal: Molecular Nutrition & Food Research • January 2024
Alzheimer's disease (AD) affects 50 million people worldwide, an increase of 35 million since 2015, and it is known for memory loss and cognitive decline. Considering the morbidity associated with AD,...
Artificial intelligence Multinomial decisions Alzheimer’s disease (ad) Machine learning (ml)
Journal: Aspects of Molecular Medicine • December 2023
Human gut microbiota plays an important role in health, broadly influencing metabolism to the immune system and drug resistance to pathogenic colonization. Since antibiotic resistance is on the rise,...
Dysbiosis Horizons of phage therapy Microbiome Bacteriophage Phage therapy Gut microbiome Antimicrobial resistance Precision medicine Microbial dysbiosis
Journal: Biochemical Journal • August 2023
Several decades after the discovery of the first antibiotic (penicillin) microbes have evolved novel mechanisms of resistance; endangering not only our abilities to combat future bacterial pandemics b...
Glmu Mycobacterium tuberculosis Peptidoglycan Tuberculosis Udp-glcnac
Journal: The Journal of Pharmacology and Experimental Therapeutics • April 2025
Approved therapies for managing opioid addiction involve intensive treatment regimens which remain both costly and ineffective. As pharmaceutical interventions have achieved variable success treating...
Opioid addiction Immunotherapy Neuropharmacology Antibodies Blood–brain barrier
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