Go Back Research Article July, 2009

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Author Emelia J. Benjamin Author Daniel B. Levy Author Martin G. Larson Author Thomas J Wang Author Ramachandran S. Vasan Author Renate B Schnabel Author Eric boerwinkle Author Arne Pfeufer

Abstract

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10−7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10−11; combined RR = 1.25; combined P = 1.8 × 10−15).

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Volume 41
Issue 8
Pages 879-881
DOI 10.1038/ng.416
ISSN 1546-1718
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