Paper Title
Synthesis of chalcone (3-(4-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one): Advantage of sonochemical method over conventional method
Keywords
- Chalcone Synthesis
- Sonochemical Method
- Conventional Method
- 4-Fluorobenzaldehyde
- 1-(4-Methoxyphenyl)Ethanone
- Potassium Hydroxide
- Condensation Reaction
- Ultrasonic Energy
- Crystallinity Enhancement
- FTIR Analysis
- NMR Spectroscopy
- Elemental Analysis
- X-Ray Diffraction
- Particle Size Measurement
- Thermogravimetric Analysis
- Scanning Electron Microscopy
- Sonochemistry
- Reaction Time Reduction
- Energy Efficiency
- Green Chemistry
- Process Intensification
- Organic Synthesis
- Chalcone Derivatives
- Catalysis
- Sustainable Synthesis
Journal
Research Impact Tools
Publication Info
Volume: 18 | Issue: 2 | Pages: 617-623
Published On
March, 2011
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Abstract
In this work, an attempt was made to synthesize chalcone (3-(4-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one) by condensation of 4-fluorobenzaldehyde with 1-(4-methoxyphenyl)ethanone under basic conditions by using both conventional (NUS) and sonochemical (US) methods. A simple condensation reaction of 4-fluorobenzaldehyde and 1-(4-methoxyphenyl)ethanone using potassium hydroxide as a base was carried out for the study. The synthesized chalcone derivative was characterized for FTIR, NMR, elemental analyses and studied for XRD, PSM, TGA and SEM properties to evaluate its performance obtained under ultrasonic energy. It was observed that complete conversion to chalcone occurred in 10 min by sonochemical method and in 4 h by conventional method. Also it was found that crystallinity of the US synthesized chalcone was found to be increased by 63% than that of NUS synthesized chalcone. Finally, it has been observed that chalcone synthesis using sonochemical method is an energy efficient technique over conventional method (almost 90% of energy saving).
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