Go Back Research Article August, 2013

Relations of arterial stiffness and endothelial function to brain aging in the community

Author Emelia J. Benjamin Author Connie W Tsao Author Daniel B. Levy Author Martin G. Larson Author Alexa S. Beiser Author Philip A. Wolf Author Ramachandran S. Vasan Author Gary F. Mitchell Author Naomi M Hamburg Author Joseph A Vita Author jayandra j himali Author Charles DeCarli

Abstract

Objective: To determine the association of arterial stiffness and pressure pulsatility, which can damage small vessels in the brain, with vascular and Alzheimer-type brain aging. Methods: Stroke- and dementia-free Framingham Offspring Study participants (n = 1,587, 61 ± 9 years, 45% male) underwent study of tonometric arterial stiffness and endothelial function (1998-2001) and brain MRI and cognition (1999-2002). We related carotid-femoral pulse wave velocity (CFPWV), mean arterial and central pulse pressure, and endothelial function to vascular brain aging by MRI (total cerebral brain volume [TCBV], white matter hyperintensity volume, silent cerebral infarcts) and vascular and Alzheimer-type cognitive aging (Trails B minus Trails A and logical memory-delayed recall, respectively).

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Volume 81
Issue 11
Pages 984-991
DOI 10.1212/WNL.0b013e3182a43e1c
ISSN 1526-632X
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