Abstract
Background: There is growing support for a hierarchical structure of first and higher-order dimensions of psychopathological symptoms, however, little is known about how these dimensions relate to genetic liability for psychiatric disorders. We therefore examined how genetic risk for schizophrenia, and other psychiatric disorders, relate to general and specific dimensions of adolescent psychopathology using a latent modelling framework. Methods: Polygenic scores (PGSs) for schizophrenia, major depressive disorder, neuroticism and bipolar disorder were generated for individuals in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Multivariate linear regression was used to examine relationships of these PGSs with psychopathology dimensions at 16 years of age, namely psychotic experiences, negative symptoms, depression and anxiety, modelled within i) a correlated factors structure
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