Paper Title
The role of phosphofructokinase in metabolic regulation
Article Type
Research Article
Journal
Research Impact Tools
Publication Info
Volume: 2 | Pages: 265-274
Published On
January, 1964
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Abstract
The kinetics of phosphofructokinase have been investigated with especial reference to possible physiological controls. ATP, citrate and Mg were found to be inhibitors for liver and brain PFK. The inhibition can be overcome wholly or in part by the presence of FDP, Pi, F6P, AMP, 3′,5′-AMP or ADP. In addition, the rate of PFK can be enhanced by these same substances, or by the addition of NH4+ or K+. The nature of the effects of various combinations of these materials has made it necessary to postulate two active substrate sites, two ATP inhibitor sites, two distinct enhancement sites, and a citrate inhibitory site.
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