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About

Lowry was the youngest of a family of five children. His father was a teacher and later an administrator in the Chicago public school system. His three brothers and sister all earned graduate degrees in various fields, and Lowry was inspired to emulate his siblings. He attended Northwestern University in Evanston, Illinois, for his undergraduate studies, having intended to major in chemical engineering. However, upon the advice of a fellow student, he ended up shifting his focus towards biochemistry.[1] After graduating from Northwestern in 1932, he enrolled at the University of Chicago, where he sought to study "physiological chemistry".[2] During his second year, a dean of the university offered Lowry admission to the university's MD-PhD program, which he accepted and from which he graduated in 1937. Despite that he earned a medical degree, Lowry never practiced medicine.[2] After graduating from the University of Chicago with his two doctoral degrees, Lowry failed in his attempt to secure a postdoctoral fellowship. He left Chicago to work at Harvard University under A. Baird Hastings. During Lowry's time at Harvard, Hastings was able to arrange for Lowry to work for five months at the Carlsberg Laboratory in Copenhagen, Denmark, where he worked with Kaj Ulrik Linderstrøm-Lang. By 1942, Otto Bessey persuaded his friend Lowry to join him at the newly established Public Health Research Institute in New York City, where Lowry would work until 1947.[1] In 1947, Washington University in St. Louis invited Lowry to head its Department of Pharmacology despite the fact that Lowry had never taken a course in pharmacology and his research was only tangentially related to that field. Nevertheless, Lowry served as the department head for the next twenty-nine years. He also served as dean of the Washington University School of Medicine from 1955 to 1958.[2] He was eventually succeeded as department head by Philip Needleman, but Lowry continued to work at Washington University for many years after becoming a Distinguished Professor Emeritus of Molecular Biology and Pharmacology.[1][3] Lowry was elected to the American Academy of Arts and Sciences in 1957 and to the National Academy of Sciences in 1964. He died of Alzheimer's disease, at the age of 85, on June 29, 1996.

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Skills

Experience

Professor Emeritus of Molecular Biology and Pharmacology

Washington University School of Medicine (WashU Medicine)

Jan-1975 to Jan-1996
Chair of the Department of Pharmacology

Washington University School of Medicine (WashU Medicine)

Jan-1947 to Jan-1976

Education

The University of Chicago (UChicago)

Ph.D. in Physiological Chemistry and Medical

Passout Year: 1937
Northwestern University (McCormick)

B.Sc. in Chemistry

Passout Year: 1932

Publication

A Flexible System of Enzymatic Analysis

A Flexible System of Enzymatic Analysis is a multipurpose manual of laboratory methods that offers a systematic scheme for the analysis of biological materials from the level of the wholeorg...

Myogenin Induces a Shift of Enzyme Activity from Glycolytic to Oxidative Metabolism in Muscles of Transgenic Mice

Physical training regulates muscle metabolic and contractile properties by altering gene expression. Electrical activity evoked in muscle fiber membrane during physical activity is crucial f...

Mitochondrial enzymes increase in muscle in response to 7-10 days of cycle exercise

Endurance exercise training induces a significant increase in the respiratory capacity of skeletal muscle. This is reflected by a training-induced increase in mitochondrial enzyme activity. ...

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

We have developed an experimental paradigm to study the mechanism by which nerve growth factor (NGF) allows the survival of sympathetic neurons. Dissociated sympathetic neurons from embryoni...

Chronic stimulation of mammalian muscle: changes in enzymes of six metabolic pathways

Twenty-one enzymes of different metabolic systems were measured in the rabbit fast-twitch tibialis anterior (TA) muscle after electrical stimulation (10 Hz, 24 h/day) for 1 day to 10 wk. Nin...

Effects of detraining on responses to submaximal exercise

Seven endurance-trained subjects were studied 12, 21, 56, and 84 days after cessation of training. Heart rate, ventilation, respiratory exchange ratio, and blood lactate concentration during...

Effects of detraining on enzymes of energy metabolism in individual human muscle fibers

Muscle biopsies were obtained from three cyclists and four runners at the end of 10-24 mo of intensive training and after intervals of detraining up to 12 wk. Control samples came from four ...

Enzymatic identification of mannose 6-phosphate on the recognition marker for receptor-mediated pinocytosis of beta-glucuronidase by human fibroblasts...

Human beta-glucuronidase (beta-D-glucuronide glucuronosohydrolase, EC 3.2.1.31), like many other glycoprotein lysosomal hydrolases, is subject to receptor-mediated endocytosis by fibroblasts...

Enzyme patterns in single human muscle fibers.

Individual muscle fibers from the biceps of five individuals were analyzed for 10 different enzymes. For each person, lactic dehydrogenase and adenylokinase were first measured in 50 to 10...

Distribution along the rat nephron of three enzymes of gluconeogenesis in acidosis and starvation

Methods were devised or modified which made it possible to measure phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase, and glucose-6-phosphatase in seven defined parts of single ...

Honours & Awards

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Borden Award
Awarded by:

Association of American Medical Colleges

Year: 1966
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Merit Award
Awarded by:

Northwestern University

Year: 1963
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John Scott Award
Awarded by:

USA

Year: 1963
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Midwest Award
Awarded by:

American Chemical Society

Year: 1962
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Award
Awarded by:

American Academy of Arts and Sciences

Year: 1957

Doctoral and Master Thesis Guided

Oliver Howe Lowry
Research Scholar:

A micro method for blood acetone bodies involving only one distillation and its application in studies on rats (Ph.D. Thesis)

Institute : University of Chicago Booth School of Business

Area of research: Biochemistry

Scholar9 Profile ID

S9-012025-0808021

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