TAXANES INDUCED PERIPHERAL NEUROPATHY IN BREAST CANCER PATIENTS

Abstract

amic behavior[3]. This interference blocks cancer cells from growing and dividing, causing them to undergo cell death. As a result, cancer cells are unable to complete mitosis, leading to cell cycle arrest and apoptosis. Taxanes have been shown to trigger several forms of cell death in cancer cells, including: Apoptosis (programmed cell death): Taxanes activate key caspases, such as caspase-3, -8, and -9, which break down cellular proteins and structures, leading to cell destruction. Necroptosis: Taxanes can induce necroptosis, a regulated form of necrosis, marked by cell