Research article

Abstract

Background: Epilepsy is a neurological disorder characterized by recurrent seizures, affecting millions of individuals worldwide. The management of epilepsy involves the use of anti-epileptic drugs, which aim to control seizures and improve the quality of life for patients. Aims & Objectives: The aim of this study was to evaluate the utilization pattern of anti-epileptic drugs in patients with epilepsy. Materials & Methods: A prospective observational study conducted at Osmania General Hospital, a tertiary care teaching hospital. Over a duration of 6 months, a total of 104 prescriptions of epilepsy patients were studied. Medication adherence and Adverse drug reactions were assessed using standardized scales. Data analysis was performed using Microsoft Excel. Results: Among 104 patients, the majority (56%) were males, and those aged 18-28 years constituted 40%. Generalized Tonic-Clonic Seizures were the most common (67%). Dual therapy was prevalent (46%), followed by monotherapy (35%) and polytherapy (19%). In monotherapy, Phenytoin was the most commonly used Antiepileptic drug (AED). Levetiracetam was common in dual and polytherapy. The majority (72%) received AEDs parenterally. Medication adherence was low in 57% of patients. Analysis identified 12 possible drug-drug interactions with phenytoin and midazolam being the most commonly involved drugs. Adverse events occurred in 10 patients, with phenytoin being the drug most frequently associated with adverse reactions. Conclusion: This study provides valuable insights into the drug prescription pattern, adherence, drug interactions, and adverse events associated with AEDs in epilepsy patients. The findings suggest the importance of vigilant monitoring and tailored management to optimize epilepsy treatment outcomes