Preventive effect of alcoholic extract of Eugenia jambolana seed on dexamethasone induced hepatic steatosis in rats.

Abstract

High dose of dexamethasone administration can cause development of non-alcoholic fatty liver. This study was conducted to screen anti-steatosis effect of Eugenia jambolana (E.J) with comparison to standard drugs. Wister Albino rats weighing between 230-250 gm were selected and divided in seven groups with each group consisting of 6 rats. G-I: Control (Normal Saline), G-II: Dexamethasone (4mg/kg/i.p), G-III: Rosiglitazone (16 mg/kg/orally), G-IV: Metformin (1 g/kg/orally), G-V: E.J (3gm/kg/orally), G-VI: E.J (6 gm/kg/orally), G-VII: E.J (12 gm/kg/orally). E.J extract and standard drugs were administered to rats, 6 days before and 6 days during dexamethasone administration. On 12th day rats were scarified under anesthesia and the liver was subjected for histopathological observation. Dexamethasone administered groups showed fatty changes in liver. Pre-administration of drugs and extract prevented the fatty changes in liver. High dose E.J extract administration showed the effect like standard drugs. E.J seed extract can be used to prevent or treat drug induced non-alcoholic fatty liver with fewer side effects