One Pot Multicomponent Synthesis Of 1, 4-DHP Derivatives by Using Hantzsch Reaction

Abstract

Dihydropyridine derivatives were synthesized via a unique, environment friendly, and highly effective one-pot multicomponent process, which produced a good to wonderful yield. An important class of low molecular weight heterocyclic scaffolds is represented by 1, 4-dihydropyridines and their derivatives. The Hantzsch pyridine synthesis was completed quickly at room temperature in solvent-free condition using various 1,3-diones and the same starting ingredient aldehyde derivatives such as 5-bromothiophene-2-carboxaldehyde and ammonium acetate in the presence of the catalyst ceric ammonium nitrate (CAN). Interestingly, we discovered that just one of the compounds had excellent antifungal activity against Candida albicans when compared to griseofulvin, while all the compounds were assessed for their in vitro antibacterial and antifungal activities. Every chemical has had its cytotoxicity evaluated using cell lines from breast tumours.