Go Back Research Article April, 1987

Identification of an Amplified, Highly Expressed Gene in a Human Glioma

Author Bert Vogelstein Author Kenneth W. Kinzler Author Albert J. Wong Author Darell Doty Bigner

Abstract

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

Details
Volume 236
Issue 4797
Pages 70-73
DOI 10.1126/science.3563490
ISSN 1095-9203
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