Science has been at the center of important scientific discovery since its founding in 1880—with seed money from Thomas Edison. Today, Science continues to publish the very best in research across the sciences, with articles that consistently rank among the most cited in the world. Science Translational Medicine is an essential platform for peer-reviewed, multidisciplinary research driving the latest medical advances. Science Signaling offers original review articles, protocols and teaching resources for the growing field of cellular signal transduction. Science Immunology publishes basic, translational and clinical research specifically about immunology across all organisms and model systems, including humans. Science Robotics covers new developments in robotics and related fields, with a dual focus on the science of robotics as well as introducing researchers more broadly to how robots can be used to accelerate scientific study. Science Advances represents the next generation of online publishing, with rapid publication of significant, full-length research that is available free to readers. Science is a weekly, peer-reviewed journal that publishes significant original scientific research, plus reviews as well as commentary on current research, science policy, and issues of interest to the broad scientific community. We seek to publish papers that are influential in their fields or across fields and that will substantially advance scientific understanding. Selected papers should present novel and broadly important data, syntheses, or concepts. We welcome submissions from all fields of science and from any source.