FULL PDF
Abstract
Objectives: The present study was planned to evaluate the hypoglycemic effect of alcohol extract of Eugenia jambolana (E.J) seed against Dexamethasone induced diabetes in Wistar rats. Materials and Methods: Rats were divided in to 9 groups. Group-I served as a control, Group-II: Dexamethasone (4mg/kg/i.p/6 days), Group-III: Metformin (500mg/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days), Group-IV: Metformin (1g/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days), Group-V: Rosiglitazone (8mg/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days), Group-VI: Rosiglitazone (16mg/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days), Group- VII: Alcohol extract of E.J (3gm/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days), Group-VIII: Alcohol extract of E.J (6gm/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days) Group-IX: Alcohol extract of E.J (12gm/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days). Standard drug and plant extract were administered their respective groups 1 to 6 days, from 7 to 12 days it was administered along with Dexamethasone (4mg/kg). On 12th day, after overnight fasting, a retro-orbital puncture was performed for obtaining blood samples to estimate the fasting blood glucose and insulin, and the same procedure was followed 30min, 60min and 120min after a glucose load of 2.5g/kg i.p for estimation of post glucose load blood glucose and insulin level. Results: Dexamethaosne group showed increased fasting and post glucose load the glucose and insulin levels when compared to normal control. Whereas E.J extract 12gm/kg group showed decreased glucose and insulin level compared to Dexamethasone group. Anti-hyperglycemic effect of E.J seed extract like as standard drugs. Conclusion: Prior administration of plant extract significantly prevents the Dexamethsone induced hyperglycemia in Wistar Albino rats. KEYWORDS: Dexamethasone, Diabetes, Eugenia jambolana, Glucose, Insulin Resistance, Insulin
View more >>