High Frequency of Mutations of the PIK3CA Gene in Human Cancers
Bert Vogelstein
Kenneth W. Kinzler
Victor E. Velculescu
Abstract
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival, and motility (1–3). To determine if PI3Ks are genetically altered in tumorigenesis, we sequenced PI3K genes in human cancers and corresponding normal tissue
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