Frequency of Cardiac Rhythm Abnormalities in a Half Million Adults

Abstract

Background: The frequency of cardiac rhythm abnormalities and their risk factors in community-dwelling adults are not well characterized. Methods: We determined the frequency of rhythm abnormalities in the UK Biobank, a national prospective cohort. We tested associations between risk factors and incident rhythm abnormalities using multivariable proportional hazards regression. Results: Of 502 627 adults (median age, 58 years [interquartile range, 13]; 54.4% women), 2.35% had a baseline rhythm abnormality. The prevalence increased with age with 4.84% of individuals aged 65 to 73 years affected. During 3 368 332 person-years of follow-up, 15 906 new rhythm abnormalities were detected (4.72 per 1000 person-years; 95% confidence interval [CI]: 4.65–4.80). Atrial fibrillation (3.11 per 1000 person-years; 95% CI: 3.05–3.17), bradyarrhythmias (0.89 per 1000 person-years; 95% CI: 0.86–0.92), and conduction system diseases (1.06 per 1000 person-years; 95% CI: 1.02–1.09) were more common than supraventricular (0.51 per 1000 person-years; 95% CI: 0.48–0.53) and ventricular arrhythmias (0.57 per 1000 person-years; 95% CI: 0.55–0.60). Older age (hazard ratio [HR]: 2.35 per 10-year increase; 95% CI: 2.29–2.41; P<0.01), male sex (HR: 1.83; 95% CI: 1.76–1.89; P<0.01), hypertension (HR: 1.49; 95% CI: 1.44–1.54; P<0.01), chronic kidney disease (HR: 1.95; 95% CI: 1.67–2.27; P<0.01), and heart failure (HR: 1.99; 95% CI: 1.76–2.26; P<0.01) were associated with new rhythm abnormalities.