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Paper Title

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Authors

Bert Vogelstein
Bert Vogelstein
Kenneth W. Kinzler
Kenneth W. Kinzler
Nickolas Papadopoulos
Nickolas Papadopoulos
Cristian Tomasetti
Cristian Tomasetti
Anne Marie Lennon
Anne Marie Lennon
Christopher Thoburn
Christopher Thoburn
Christopher B. Douville
Christopher B. Douville
Ammar A. Javed
Ammar A. Javed

Article Type

Research Article

Journal

Science

Research Impact Tools

Issue

Volume : 359 | Issue : 6378 | Page No : 926-930

Published On

January, 2018

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Abstract

Many cancers can be cured by surgery and/or systemic therapies when detected before they have metastasized. This clinical reality, coupled with the growing appreciation that cancer's rapid genetic evolution limits its response to drugs, have fueled interest in methodologies for earlier detection of the disease. Cohen et al. developed a noninvasive blood test, called CancerSEEK that can detect eight common human cancer types (see the Perspective by Kalinich and Haber). The test assesses eight circulating protein biomarkers and tumor-specific mutations in circulating DNA. In a study of 1000 patients previously diagnosed with cancer and 850 healthy control individuals, CancerSEEK detected cancer with a sensitivity of 69 to 98% (depending on cancer type) and 99% specificity.

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