Microbes have made a phenomenal contribution to the health and well-being of people throughout the world. Beneficial microbes can represent the future of medicine with the potential to treat a variety of diseases in humans and animals. Usually microbes can be used to treat a range of clinical conditions that have been linked to pathogens. In addition to producing many primary metabolites, such as amino acids, vitamins and nucleotides, they are capable of making secondary metabolites/enzymes, which constitute half of the pharmaceuticals on the market today. This review centers on these beneficial aspects of microbes and their enzymes.