Anti-Inflammatory And Analgesic Activity Of Leaves Of White Flowered Variety of Clitoria ternatea Linn

Abstract

In this study, we investigated the effects of methanolic extract of Clitoria ternatea (MECT) leaves on anti-inflammatory and analgesic activities in vivo using rat as an animal model at the doses of 250 mg/kg and 500 mg/kg body weight. The anti-inflammatory activities were investigated by utilizing carrageenan induced paw edema in rat. The analgesic activity was examined against hot plate method in rats. The results showed that CT significantly (p<0.001) reduced carrageenan induced paw edema in rats. In hot plate method, methanolic extract of Clitoria ternatea has shown increase in reaction time i.e. paw licking maintained at 55°C indicating analgesic activity. Preliminary phytochemical screening of the extract revealed the presence of phenolic compounds, alkaloids, tannins, glycosides and flavonoids. These results demonstrated that the methanolic extract of Clitoria ternatea (CT) leaves exhibited significant analgesic and anti-inflammatory activities.