Jyoti V Thaikoottathil
About
I have research expertise in airway cell biology, lung diseases such as asthma,COPD, acute lung injury, innate immunity, gene regulation and cancer biology. I have strong interest in building translational research program involving effects of environmental toxicant / pollutant exposure on human health with special interest in lung and heart diseases. Currently I am monitoring in vitro regulatory toxicity studies (Non-GLP & GLP) at extrenal CROs.
Research Experience - Basic and translational research focused on inflammatory lung diseases such as asthma, COPD, respiratory infections. Antimicrobial protein/ gene regulation in airway epithelium. Preclinical drug development (in vitro ADMET studies) < 2 yrs , Regulatory in vitro toxicity studies <1 yr. Effects of environmental toxicant exposures (cigarette smoke, ambient fine particles and metal oxide nanoparticles) on human health with regards to lung and heart disease (>8 yrs).
Adenoid cystic carcinoma (ACC) studies using primary tumour cells and mouse xenograft (PDX) models (4 yrs).
Specialties: Airway innate immunity, allergic asthma and infection, Airway cell biology, cell signalling, transcriptional regulation of genes, Acute lung injury, Oncology (solid tumour), Human aortic endothelial cell biology study with fluid shear stress and environmental toxicant exposures. Regulatory in vitro toxicology.
Skills & Expertise
PCR
ELISA
Gene Regulation
Cell Culture
Protein Expression
Molecular Biology
Immunology
Cancer
Flow Cytometry
Data Analysis
Conflict Resolution
Research Interests
Biochemistry
Cell Biology
Cancer Biology
Biology
Airway epithelial biology
Environmental pollutants
Human Health
Connect With Me
Experience
Associate Professor
Cell Culture · Airway epithelial cell biology
Assistant Professor
Senior Scientist II
In vitro regulatory toxicity studies (Non-GLP & GLP) at external CROs
New assay development (Mechanistic assays), Scientific writing and review - study reports, manuscript/ abstracts/ poster.
Research Associate
Human primary tumor cell isolation from PDX, cell characterization and culture, study design, execution, data analysis, interpretation, presentation, scientific writing, leading collaborative/ cross-functional research projects.
Study the role of MYB in adenoid cystic carcinoma (ACC) pathology using xenograft (PDX) and primary ACC cell culture models and explore its potential to design a targeted therapy for ACC.
Evaluation of anti-cancer activity of small molecule inhibiotrs and peptides in primary human ACC cellsHuman primary tumor cell isolation from PDX, cell characterization and culture, study design, execution, data analysis, interpretation, presentation, scientific writing, leading collaborative/ cross-functional research projects. Study the role of MYB in adenoid cystic carcinoma (ACC) pathology using xenograft (PDX) and primary ACC cell culture models and explore its potential to design a targeted therapy for ACC. Evaluation of anti-cancer activity of small molecule inhibiotrs and peptides in primary human ACC cells
Skills: Cell Culture · Biochemistry
Assistant Professor
Teaching undergraduate and postgraduate students Cell Biology and Biochemistry.
Education
The Maharaja Sayajirao University of Baroda (MSUB)
Devi Ahilya University, Indore
Vikram University, Ujjain
Certificates & Licenses (1)
Jodi Glickman on Pitching Yourself
Publications (2)
The airway epithelium constitutes a protective barrier against inhaled insults, such as viruses, bacteria, and toxic fumes, including cigarette smoke (CS). Maintenance of bronchial epithelial integrit...
The receptor tyrosine kinase human epidermal growth factor receptor-2 (HER2) is known to regulate pulmonary epithelial barrier function; however, the mechanisms behind this effect remain unidentified....
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