FORMULATION AND CHARACTERISATION OF ORAL FAST DISSOLVING FILMS OF MOEXIPRIL

Abstract

The aim of the present investigation is to design, formulate and evaluate the oral fast dissolving films of Moexipril, to improve the bioavailability and thereby providing fast onset of action to treat mild to moderate hypertension. Oral thin films offer fast, accurate dosing in a safe, efficacious format that is convenient and portable, without the need for water or measuring devices. Oral fast dissolving film-containing Moexipril can be prepared by solvent casting method. 2% w/v of HPMC E6 (F5) film exhibited required tensile strength, folding endurance and disintegration time. Mouth dissolving time and disintegration time of the films were increased with increase in the concentration of the polymer, as more fluid is required to wet the film in the mouth. The drug release was about 98.5 % in 10min. Fast dissolving drug delivery system of Moexipril was successfully developed in the form of fast dissolving oral films which offers a suitable and practical approach in serving desired objective of faster disintegration and dissolution characteristic with increase in patient compliance by avoiding first pass metabolism and enhance the bioavailability of the drug. From the present investigation it can be concluded that oral fast dissolving film formulation can be a potential novel drug dosage form for geriatric and also for general population.