Abstract
A new Series of novel N-Substituted 1,3,4-Oxadiazole derivatives (3a-3f) were synthesized by the reacting 3,5-dinitrobenzoic acid and subsequent treatment with thiourea by microwave assisted synthesis as green chemistry. Confirmation of the chemical structure of the synthesized compounds was substantiated by TLC, IR, 1HNMR, and MS spectroscopy. Synthesized compounds were screened for anticancer activity on MCF7 cell line. All synthesized compounds exhibit significant biological activity and certainly hold a greater promise for discovering potent biologically active molecules. Further the compounds 3b, 3c and 3e has been moderate tested for its anticancer activity and out of these all, compound 3c showed most notable anticancer activity against breast cancer cell line. Molecules under study were analysed for ADME properties using SwissADME servers. ADME profiles were evaluated and most of the molecules were found to be suitable for further studies. In silico ADMET analysis is proved to be a good tool in drug discovery.