Recent Advancements in the Transdermal Drug Delivery of Quercetin

Abstract

Quercetin is a naturally occurring polyphenolic flavonoid that is found in abundance in fruits, vegetables, and medicinal plants. It contains a wide range of pharmacological activities, including antioxidant, antiinflammatory, anti-cancer, neuroprotective, and cardioprotective actions. On the other hand, the practical use of quercetin's therapeutic potential has been hindered by the compound's low bioavailability, quick metabolism, restricted tissue distribution, and poor solubility in water. By avoiding the gastrointestinal system, promoting prolonged release, and increasing skin permeability of quercetin, transdermal drug administration presents a viable strategy to overcoming these obstacles.