Paper Title

Prevalence of ras gene mutations in human colorectal cancers

Authors

Profile picture of Bert Vogelstein
Bert Vogelstein
Profile picture of Stanley R. Hamilton
Stanley R. Hamilton

Journal

Nature External link

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DOI

DOI Icon 10.1038/327293a0

Publication Info

Volume: 327 | Issue: 6120 | Pages: 293–297

Published On

May, 1987

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Abstract

The Department of Medical Biochemistry and t Department of Organic Chemistry, State University of Leiden, Sylvius Laboratories, The Netherlands * The Oncology Center and t Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

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