Paper Title

Pharmacotherapy of Paraphilias With Luteinizing Hormone–Releasing Hormone Agonists

Keywords

Luteinizing Hormone-Releasing Hormone
LH-RH Agonists
Paraphilias
Sexual Offending
Testosterone Production
Pituitary Gland
Neurobiology of Sexual Function
Sexual Function
Hormonal Treatment
Paraphilia Treatment
Endocrine Therapy
Hormonal Modulation
Sexual Behavior
Neuroendocrine Regulation

Article Type

Research Article

Journal

Archives of General Psychiatry

Issue

Volume : 59 | Issue : 5 | Page No : 469-470

Published On

May, 2002

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Abstract

In the November 2000 issue of the ARCHIVES, Meston and Frohlich1 provided a review of the past and current literature on the neurobiology of sexual function. We would like to add some facts about luteinizing hormone–releasing hormone (LH-RH) agonists. Experiences with LH-RH agonists have suggested that they might also be helpful in the treatment of paraphilias, especially in connection with sexual offending. Luteinizing hormone–releasing hormone agonists inhibit the production of testosterone by overwhelming the pulsatile stimulation of the pituitary gland by constant stimulation.