Paper Title
Natural History of Multiple Human Papillomavirus Infections in Female Adolescents With Prolonged Follow-up
Keywords
- human papillomavirus
- hpv infection
- multiple infections
- female adolescents
- natural history
- longitudinal study
- sexual activity
- hpv prevalence
- high-risk hpv
- low-risk hpv
- hpv-16
- hpv-18
- oncogenic types
- vaccine strategies
- non-vaccine prevention
- cervical cancer
- hpv persistence
- viral typing
- hpv clearance
- sexual health
- hpv screening
- adolescent health
- hpv epidemiology
- infection duration
- hpv transmission
- sti prevention
- hpv follow-up
- hpv risk factors
- hpv detection
- vaginal samples
- hpv
Article Type
Original Article
Journal
Research Impact Tools
Publication Info
Volume: 48 | Issue: 5 | Pages: 473–480
Published On
May, 2011
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Abstract
Purpose The aim of the study was to better characterize the natural history of human papillomavirus (HPV) infections in female adolescents. Methods Female adolescents were enrolled in a longitudinal study. Self-vaginal samples were obtained every 3 months and tested for HPV. No participants received HPV vaccination. The findings for 40 female adolescents with the longest follow-up are reported in this study. Results Average age at the time of enrollment was 15.2 years (range: 14–17; SD: .97). Mean duration of follow-up was 6.7 years (range: 4.4–9.2; SD: 1.2). In all, 32 participants (80%) reported being involved in sexual activity before their enrollment in the study; all reported being involved in sexual activity before enrollment; all reported being involved in sexual activity during follow-up. Baseline and cumulative prevalence of HPV among participants was 55% and 100%, respectively. During the study, each participant tested positive for a mean of 14 HPV types. Cumulatively, HPV 16 was detected in 29 of 40 participants (72.5%). Mean duration of high- and low-risk infections was 655.9 (median: 433) and 524.1 days (median: 334), respectively. Conclusion With prolonged follow-up, HPV infections with multiple types were found in all participants. Most had infection with HPV-16 or HPV-18, the oncogenic types represented in current vaccines, as well as infection with other oncogenic types. These data reinforce the importance of vaccine and non-vaccine strategies for prevention of HPV infections.
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