Fabrication and Mechanical Characterization of Electrospun Nanofiber Scaffolds for Guided Tissue Engineering in Cartilage Repair and Regeneration

Abstract

Cartilage tissue engineering has emerged as a promising solution for repairing and regenerating damaged cartilage, overcoming the limitations of conventional treatments such as autografts and allografts. Electrospun nanofiber scaffolds have garnered significant attention due to their biomimetic structure, mechanical properties, and biocompatibility, which provide a conducive environment for chondrocyte growth and extracellular matrix (ECM) deposition. This study explores the fabrication and mechanical characterization of electrospun nanofiber scaffolds specifically designed for guided tissue engineering in cartilage repair. The electrospinning process, fiber morphology, mechanical strength, and biological performance of these scaffolds are analyzed. The study also evaluates recent advancements in scaffold modifications, including composite materials and biofunctionalization strategies. The findings contribute to the development of optimized scaffolds for enhanced cartilage regeneration.