Evaluation of Nephroprotective Effect of Carica Papaya Root Extract in Paracetamol Induced Nephrotoxicity in Experimental Rats

Abstract

The purpose of this study is to evaluate if ahydroalcoholic root extract of Carica papaya hasany nephroprotective qualities in Wistar rats withparacetamol-induced nephrotoxicity (PCM). Whenused in excessive doses, paracetamol (PCM), ananalgesic and antipyretic, can cause liver andkidney necrosis in humans and animals. Theanimals were put into four groups of six each. Thepurpose of this study was to look into the effects ofCarica papaya hydroalcoholic extract [200 mg/kgand 400 mg/kg] on Paracetamol-inducednephrotoxicity. For 7 days, the first group wasgiven distilled water as a control, while the othergroups were given Paracetamol alone (750 mg/kg),Paracetamol+200 mg/kg extract, andParacetamol+400 mg/kg extract. Treatment withHACP root extract at doses of 200mg/kg and400mg/kg prevented kidney damage caused byParacetamol and free radical induced kidneydamage, as well as a significant decrease in weightof kidney, blood urea level, blood creatinine level,urinary glucose level, and urinary potassium level,as well as an increase in body weight, volume ofurine, urine creatinine level, and total blood proteinlevel. HACP substantially increased tissue GSHwhile decreasing lipid peroxidation. Histologicalobservations confirmed that HACP therapyrestored the degenerative effects of paracetamol.Finally, these above findings indicated that HACP has nephroprotective properties