Dry Granulation by Slugging Method for Sustained Release of Model Drug

Abstract

The main objective of the present study was to develop directly compressible co-processed excipients by the slugging method for the sustained delivery of a model drug and to study the effect of particle size and concentration of polymer on the drug release by comparing In-vitro dissolution profile of a sustained- release tablet. The co-processed excipients were prepared by wet granulation technique by using MCC (PH102) and HPMC (K4M) in the ratio of 1:0.5, 1:1, 1:2 & 1:3 respectively by passing through different sieve number 18#, 20#, 30# and 40#. In the Preformulation study of co-processed excipients, it was found that a granule of size 18# has good flow properties and faster drug release as compared to the 20#, 30# &40#. As the concentration of HPMC (K4M) increases, the release of the drug from the tablet also get decreased but the difference was found to be insignificant (Tuckey test).