Trends in Molecular Medicine's objective is to provide concise and contextualized views on the latest research moving biomedical science closer to improved diagnosis, treatment, and prevention of human diseases. As such, TMM is dedicated to research disciplines at the interface between basic biology and clinical research. Articles cover new concepts in mechanisms of human biology and pathology with clear implications for diagnostics and therapy. Bridging “bench and bedside”, reviews published in TMM have clear implications for human health and disease and discuss not only preclinical studies but also research conducted on patient samples, first-in-man studies, and patient-enrolled trials. The major themes covered in TMM in include: Disease mechanisms Tools and technologies Diagnostics Therapeutics We particularly seek articles that are relevant to more than one of these themes. The goal of TMM is to serve as platform for discussion, push the boundaries of traditional clinical or scientific categorization and forge new links between scientists and clinicians. TMM reviews and opinions serve as templates for future explorations in molecular medicine, and to inspire new directions of studies toward improving human health. The journal’s focus is on publishing articles that are provocative and authoritative but also accessible to a broad audience.