Cell Biology
Cell Biology
Editor(s): Nick Bisceglia | Subscribe
Cell biology is the study of cell structure and function, and it revolves around the concept that the cell is the fundamental unit of life. Focusing on the cell permits a detailed understanding of the tissues and organisms that cells compose. Some organisms have only one cell, while others are organized into cooperative groups with huge numbers of cells. On the whole, cell biology focuses on the structure and function of a cell, from the most general properties shared by all cells, to the unique, highly intricate functions particular to specialized cells.
The starting point for this discipline might be considered the 1830s. Though scientists had been using microscopes for centuries, they were not always sure what they were looking at. Robert Hooke's initial observation in 1665 of plant-cell walls in slices of cork was followed shortly by Antonie van Leeuwenhoek's first descriptions of live cells with visibly moving parts. In the 1830s two scientists who were colleagues — Schleiden, looking at plant cells, and Schwann, looking first at animal cells — provided the first clearly stated definition of the cell. Their definition stated that that all living creatures, both simple and complex, are made out of one or more cells, and the cell is the structural and functional unit of life — a concept that became known as cell theory.
As microscopes and staining techniques improved over the nineteenth and twentieth centuries, scientists were able to see more and more internal detail within cells. The microscopes used by van Leeuwenhoek probably magnified specimens a few hundredfold. Today high-powered electron microscopes can magnify specimens more than a million times and can reveal the shapes of organelles at the scale of a micrometer and below. With confocal microscopy a series of images can be combined, allowing researchers to generate detailed three-dimensional representations of cells. These improved imaging techniques have helped us better understand the wonderful complexity of cells and the structures they form.
There are several main subfields within cell biology. One is the study of cell energy and the biochemical mechanisms that support cell metabolism. As cells are machines unto themselves, the focus on cell energy overlaps with the pursuit of questions of how energy first arose in original primordial cells, billions of years ago. Another subfield of cell biology concerns the genetics of the cell and its tight interconnection with the proteins controlling the release of genetic information from the nucleus to the cell cytoplasm. Yet another subfield focuses on the structure of cell components, known as subcellular compartments. Cutting across many biological disciplines is the additional subfield of cell biology, concerned with cell communication and signaling, concentrating on the messages that cells give to and receive from other cells and themselves. And finally, there is the subfield primarily concerned with the cell cycle, the rotation of phases beginning and ending with cell division and focused on different periods of growth and DNA replication. Many cell biologists dwell at the intersection of two or more of these subfields as our ability to analyze cells in more complex ways expands.
In line with continually increasing interdisciplinary study, the recent emergence of systems biology has affected many biological disciplines; it is a methodology that encourages the analysis of living systems within the context of other systems. In the field of cell biology, systems biology has enabled the asking and answering of more complex questions, such as the interrelationships of gene regulatory networks, evolutionary relationships between genomes, and the interactions between intracellular signaling networks. Ultimately, the broader a lens we take on our discoveries in cell biology, the more likely we can decipher the complexities of all living systems, large and small.
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