eBioMedicine covers the spectrum of biomedical research, from preclinical studies with clear human relevance, through to proof-of-concept, first-in-human studies, and early phase clinical trials. We are dedicated to publishing original research that investigates the basic determinants of human health and disease, the discovery and characterization of new therapeutic targets and treatments, and the identification of biomarkers and diagnostic tools which may help researchers and clinicians better understand and monitor disease. We welcome studies that elucidate, or aim to modify, disease pathways and mechanisms—with the goal of advancing knowledge in any biomedical discipline with relevance to human health. We aspire to catalyse dialogue and collaboration between basic scientists, clinical researchers, and healthcare professionals; enhance the accessibility and applicability of basic research findings for health professionals; and promote a better understanding of clinical challenges for biomedical researchers.