Cold Spring Harbor Perspectives in Biology is a monthly online publication comprising of reviews spanning the complete spectrum of the molecular life sciences. Cold Spring Harbor Perspectives in Biology provides the life sciences community with authoritative analyses of progress in emerging areas of molecular, cell, and developmental biology, genetics, evolutionary biology, neuroscience, cancer biology, and molecular pathology. The contributions are written by leading researchers in each field and commissioned as Subject Collections by a board of eminent academic editors, all of whom are acknowledged to be key figures in their particular fields. These Subject Collections gradually accumulate articles as new issues of the journal are published and, when complete, each represents a comprehensive survey of the field it covers. Cold Spring Harbor Perspectives in Biology is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in the molecular life sciences.